Regulating RNA by cations

Project of Research Lab of Nadine Schwierz

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Positively charged cations are essential for the stability and function of RNA. In particular, changes in the local salt concentration or the type of cations present in solution immediately influence RNA regulatory elements and their regulatory functions. We will apply molecular dynamics simulations to elucidate the fundamental interplay of cations and RNA regulation. We will focus on the mechanism of ion selectivity and exchange for the example of an RNA G-quadruplex. In addition, we aim to resolve the mechanism of cation sensing of the guanidine-II riboswitch.

Regulating RNA by cations

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