Werner Kühlbrandt: Structural Biology – Department Publications

D'Imprima, E.; Salzer, R.; Bhaskara, R. M.; Sánchez, R.; Rose, I.; Kirchner, L.; Hummer, G.; Kühlbrandt, W.; Vonck, J.; Averhoff, B.: Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus. eLife 6, 10.7554/eLife.30483 (2017)

Klusch, N.; Murphy, B. J.; Mills, D.; Yildiy, Ö.; Kühlbrandt, W.: Structural basis of proton translocation and force generation in mitochondrial ATP synthase. eLife 6, e33274 (2017)

Bausewein, T.; Mills, D. J.; Langer, J. D.; Nitschke, B.; Nussberger, S.; Kühlbrandt, W.: Cryo-EM Structure of the TOM Core Complex from Neurospora crassa. Cell 170 (4), pp. 693 - 700 (2017)

Brandt, T.; Mourier, A.; Tain, L. S.; Partridge, L.; Larsson, N.-G.; Kühlbrandt, W.: Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila. eLife 6, e24662 (2017)

Daum, B.; Vonck, J.; Bellack, A.; Chaudhury, P.; Reichelt, R.; Albers, S.-V.; Rachel, R.; Kühlbrandt, W.: Structure and in situ organisation of the Pyrococcus furiosus archaellum machinery. eLife 6, e27470 (2017)

van Pee, K.; Neuhaus, A.; D'Imprima, E.; Mills, D. J.; Kühlbrandt, W.; Yildiz, Ö.: CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin. eLife 6, e23644 (2017)

Blees, A.; Januliene, D.; Hofmann, T.; Koller, N.; Schmidt, C.; Trowitzsch, S.; Moeller, A.; Tampe, R.: Structure of the human MHC-I peptide-loading complex. Nature 551, pp. 525 - 528 (2017)

Christiansen, S. H.; Murphy, R. A.; Juul-Madsen, K.; Fredborg, M.; Hvam, M. L.; Axelgaard, E.; Skovdal, S. M.; Meyer, R. L.; Sørensen, U. B. S.; Möller, A. et al.; Nyengaard, J. R.; Nørskov-Lauritsen, N.; Wang, M.; Gadjeva, M.; Howard, K. A.; Davies, J. C.; Petersen, E.; Vorup-Jensen, T.: The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria. Scientific Reports 7, 15653, pp. 1 - 16 (2017)

Diskowski, M.; Mehdipour, A. R.; Wunnicke, D.; Mills, D. J.; Mikusevic, V.; Bärland, N.; Hoffmann, J.; Morgner, N.; Steinhoff, H.-J.; Hummer, G.: Helical jackknives control the gates of the double-pore K⁺ uptake system KtrABs. eLife, pp. 1 - 21 (2017)

Gold, V. A. M.; Chroscicki, P.; Bragoszewski, P.; Chacinska, A.: Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo‐tomography. EMBO Reports 18, pp. 1786 - 1800 (2017)

He, C.; Preiss, L.; Wang, B.; Fu, L.; Wen, H.; Zhang, X.; Cui, H.; Meier, T.; Yin, D.: Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-Dimethylaminomethyl)phenyl)quinoline-Derived Antitubercular Lead Compounds. ChemMedChem 12, pp. 106 - 119 (2017)

Januliene, D.; Andersen, J. L.; Nielsen, J. A.; Quistgaard, E. M.; Hansen, M.; Strandbygaard, D.; Moeller, A.; Petersen, C. M.; Madsen, P.; Thirup, S. S.: Acidic Environment Induces Dimerization and Ligand Binding Site Collapse in the Vps10p Domain of Sortilin. Structure 25 (12), pp. 1809 - 1819 (2017)

Januliene, D.; Manavalan, A.; Ovesen, P. L.; Pedersen, K.-M.; Thirup, S.; Nykjær, A.; Moeller, A.: Hidden Twins: SorCS Neuroreceptors Form Stable Dimers. Journal of Molecular Biology (London) 429 (19), pp. 2907 - 2917 (2017)

Kohler, R.; Mooney, R. A.; Mills, D. J.; Landick, R.; Cramer, P.: Architecture of a transcribing-translating expressome. Science 356, pp. 194 - 197 (2017)

López-Alonso, J. P.; Kaminishi, T.; Kikuchi, T.; Hirata, Y.; Iturrioz, I.; Dhimole, N.; Schedlbauer, A.; Hase, Y.; Goto, S.; Kurita, D. et al.; Muto, A.; Zhou, S.; Naoe, C.; Mills, D. J.; Gil-Carton, D.; Takemoto, C.; Himeno, H.; Fucini, P.; Connell, S. R.: RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket. Nucleic Acids Research 45 (11), pp. 6945 - 6959 (2017)

Mühleip, A. W.; Dewar, C. E.; Schnaufer, A.; Kühlbrandt, W.; Davies, K. M.: In situ structure of trypanosomal ATP synthase dimer reveals a unique arrangement of catalytic subunits. Proceedings of the National Academy of Sciences of the United States of America 114 (5), pp. 992 - 997 (2017)

Nürnberger, P.; Reinhardt, H. M.; Rhinow, D.; Riedel , R.; Werner, S.; Hampp, N. A.: Controlled growth of periodically aligned copper-silicide nanocrystal arrays on silicon directed by laser-induced periodic surface structures (LIPSS). Applied Surface Science 420, pp. 70 - 76 (2017)

Payer, S. E.; Marshall, S. A.; Bärland, N.; Sheng, X.; Reiter, T.; Dordic, A.; Steinkellner, G.; Wuensch, C.; Kaltwasser, S.; Fisher, K. et al.; Rigby, S. E. J.; Macheroux, P.; Vonck, J.; Gruber, K.; Faber, K.; Himo, F.; Leys, D.; Pavkov-Keller, T.; Glueck, S. M.: Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase. Angewandte Chemie, International Edition in English 56 (44), pp. 13893 - 13897 (2017)

Retel, J. S.; Nieuwkoop, A. J.; Hiller, M.; Higman, V. A.; Barbet-Massin, E.; Stanek, J.; Andreas, L. B.; Franks, W. T.; van Rossum, B.-J.; Vinothkumar, K. R. et al.; Handel, L.; de Palma, G. G.; Bardiaux, B.; Pintacuda, G.; Emsley, L.; Kühlbrandt, W.; Oschkinat, H.: Structure of outer membrane protein G in lipid bilayers. Nature Communications 8, 2073, p. 1 (2017)

Scherr, J.; Parey, K.; Klusch, N.; Murphy, B. J.; Balser, S.; Neuhaus, A.; Zickermann, V.; Kühlbrandt, W.; Terfort, A.; Rhinow, D.: Self-Perforated Hydrogel Nanomembranes Facilitate Structural Analysis of Proteins by Electron Cryo-Microscopy. ACS Nano 11 (6), pp. 6467 - 6473 (2017)

Schulz, S.; Wilkes, M.; Mills, D. J.; Kühlbrandt, W.; Meier, T.: Molecular architecture of the N‐type ATPase rotor ring from Burkholderia pseudomallei. EMBO Reports 18 (6), pp. 1 - 10 (2017)

Schumacher, D.; Bergeler, S.; Harms, A.; Vonck, J.; Huneke-Vogt, S.; Frey, E.; Søgaard-Andersen, L.: The PomXYZ Proteins Self-Organize on the Bacterial Nucleoid to Stimulate Cell Division. Developmental Cell 41, pp. 299 - 314 (2017)

Vonck, J.; Mills, D. J.: Advances in high-resolution cryo-EM of oligomeric enzymes. Current Opinion in Structural Biology 46, pp. 48 - 54 (2017)

Weston, C. E.; Krämer, A.; Colin, F.; Yildiz, Ö.; Baud, M. G. J.; Meyer-Almes, F.-J.; Fuchter, M. J.: Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors. ACS Infect. Dis. 3 (2), pp. 152 - 161 (2017)

Wilkes, M.; Madej, G. M.; Kreuter, L.; Rhinow, D.; Heinz, V.; De Sanctis, S.; Ruppel, S.; Richter, R. M.; Joos, F.; Grieben, M. et al.; Pike, A. C. W.; Huiskonen, J. T.; Carpenter, E. P.; Kühlbrandt, W.; Witzgall, R.: Molecular insights into lipid-assisted Ca²⁺ regulation of the TRP channel Polycystin-2. Nature Structural and Molecular Biology 24 (2), pp. 123 - 130 (2017)

Gold, V. A. M.; Brandt, T.; Cavellini, L.; Cohen, M. M.; Ieva, R.; van der Laan, M.: Analysis of Mitochondrial Membrane Protein Complexes by Electron Cryo-tomography. In: Mitochondria. Methods in Molecular Biology (MIMB), Vol. 1567, pp. 315 - 336. Humana Press, New York (2017)

Mühleip, A.: Tomographic studies of mitochondrial membrane-shaping proteins. Dissertation, Goethe-Universtität, Frankfurt am Main (2017)

Wöhlert, D.: Structures and mechanism of secondary active transporters. Dissertation, 194 pp., Fachbereich Biochemie, Chemie und Pharmazie, Goethe-Universität, Frankfurt am Main (2017)