Publikationen 2017 - Strukturbiologie

Bausewein, T., Mills, D. J., Langer, J. D., Nitschke, B., Nussberger, S., and Kühlbrandt, W.: Cryo-EM Structure of the TOM Core Complex from Neurospora crassa.
Cell 170 (4) 693-700 (2017). doi

Blees, A., Januliene, D., Hofmann, T., Koller, N., Schmidt, C., Trowitzsch, S., Moeller, A., and Tampé, R.: Structure of the human MHC-I peptide-loading complex.
Nature 551 525-528, doi: 10.1038/nature24627 (2017). online

Brandt, T., Mourier, A., Tain, L. S., Partridge, L., Larsson, N.-G., and Kühlbrandt, W.: Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila.
eLife 19 pp., doi: 10.7554/eLife.24662 (2017). online

Christiansen, S. H., Murphy, R. A., Juul-Madsen, K., Fredborg, M., Hvam, M. L., Axelgaard, E., Skovdal, S. M., Meyer, R. L., Sørensen, U. B. S., Möller, A., Nyengaard, J. R., Nørskov-Lauritsen, N., Wang, M., Gadjeva, M., Howard, K. A., Davies, J. C., Petersen, E., and Vorup-Jensen, T.: The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria.
Sci. Rep. 7 art. no.: 15653, 16 pp., doi: 10.1038/s41598-017-15969-3 (2017). online

Daum, B., Vonck, J., Bellack, A., Chaudhuri, P., Reichelt, R., Albers, S.-V., Rachel, R., and Kühlbrandt, W.: Structure and in situ organisation of the of Pyrococcus furiosus archaellum machinery.
eLife 21 pp., doi: 10.7554/eLife.27470 (2017). online

D'Imprima, E., Salzer, R., Ramachandra, M., Bhaskara, R., Sánchez, R., Rose, I., Kirchner, L., Hummer, G., Kühlbrandt, W., Vonck, J., and Averhoff, B.: Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus.
eLife, doi: 10.7554/eLife.30483 (2017). online

Diskowski, M., Mehdipour, A. R., Wunnicke, D., Mills, D. J., Mikusevic, V., Bärland, N., Hoffmann, J., Morgner, N., Steinhoff, H.-J., Hummer, G., Vonck, J., and Hänelt, I.: Helical jackknives control the gates of the double-pore K+ uptake system KtrABs.
eLife 21 pp., doi: 10.7554/eLife.24303 (2017). online

Gold, V. A. M, Brandt, T., Cavellini, L., Cohen, M. M., Ieva, R., and van der Laan, M.: Analysis of Mitochondrial Membrane Protein Complexes by Electron Cryo-tomography.
Part of the Methods in Molecular Biology book series (MIMB), Mitochondria: Practical Protocols 1567 315-336, edts.: D. Mokranjac and F. Perocchi, Humana Press, New York, NY (2017). doi

Januliene, D., Andersen, J. L., Nielsen, J. A., Quistgaard, E., M., Hansen, M., Stranbygard, D., Moeller, A., Petersen, C. M., Madsen, P., and Thirup, S. S.: Acidic Environment Induces Dimerization and Ligand Binding Site Collapse in the Vps10p Domain of Sortilin.
Struct. 25 (12) 1809-1819 (2017). doi

Januliene, D., Manavalan, A., Ovesen, P. L., Pedersen, K.-M., Thirup, S., Nykjær, A., and Moeller, A.: Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.
J. Mol. Biol. 429 (19) 2907-2917 (2017). doi

Klusch, N., Murphy, B. J., Mills, D. J., Yildiz, Ö., and Kühlbrandt, W.: Structural basis of proton translocation and force generation in mitochondrial ATP synthase.
eLife 16 pp. (2017). doi

Kohler, R., Mooney, R. A., Mills, D. J., Landick, R., and Cramer, P.: Architecture of a transcribing-translating expressome.
Science 356 (6334) 194-197, doi: 10.1126/science.aal3059 (2017). online

López-Alonso, J. P., Kaminishi, T., Kikuchi, T., Hirata, Y., Iturrioz, I., Dhimole, N., Schedlbauer,A., Hase, Y., Goto, S., Kurita, D., Muto, A., Zhou, S., Naoe, C., Mills, D. J., Gil-Carton, D., Takemoto, C., Himeno, H., Fucini, P., and Connell, S. R.: RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket.
Nucleic Acids Res. 45 (11) 6945-6959, (2017). doi

Mühleip, A. W., Dewar, C. E., Schnaufer, A., Kühlbrandt, W., and Davies, K. M.: In situ structure of trypanosomal ATP synthase dimer reveals a unique arrangement of catalytic subunits.
Proc. Natl. Acad. Sci. USA 114 (5) 992-997, doi: 10.1073/pnas.1612386114 (2017). online

Nürnberger, P., Reinhardt, H. M., Rhinow, D., Riedel, R., Werner, S., and Hampp, N. A.: Controlled growth of periodically aligned copper-silicide nanocrystal arrays on silicon directed by laser-induced periodic surface structures (LIPSS).
Appl. Surf. Sci. 420 70-76 (2017). doi

Payer, S. E., Marshall, S. A., Bärland, N., Sheng, X., Reiter, T., Dordic, A., Steinkellner, G., Wuensch, C., Kaltwasser, S., Fisher, K., Rigby, S. E. J., Macheroux, P., Vonck, J., Gruber, K., Faber, K., Himo, F., Leys, D., Pavkov-Keller, T., and Glueck, S. M.: Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase.
Angew. Chem. Int. Ed. 56 (44) 13893-13897 (2017). doi

Retel, J. S., Nieuwkoop, A. J., Hiller, M., Higman, V. A., Barbet-Massin, E., Stanek, J., Andreas, L. B., Franks, W. T., van Rossum, B.-J., Vinothkumar, K. R., Handel, L., de Palma, G. G., Bardiaux, B., Pintacuda, G., Emsley, L., Kühlbrandt, W., and Oschkinat, H.: Structure of outer membrane protein G in lipid bilayers.
Nat. Commun. 8 art. no. 2073, 10 pp., doi: 10.1038/s41467-017-02228-2 (2017). online

Scherr, J., Parey, K., Klusch, N., Murphy, B. J., Balser, S., Neuhaus, A., Zickermann, V., Kühlbrandt, W., Terfort, A., and Rhinow, D.: Self-Perforated Hydrogel Nanomembranes Facilitate Structural Analysis of Proteins by Electron Cryo-Microscopy.
ACS Nano 11 (6) 6467-6473 (2017). doi

Schulz, S., Wilkes, M., Mills, D. J., Kühlbrandt, W., and Meier, T.: Molecular architecture of the N‐type ATPase rotor ring from Burkholderia pseudomallei.
EMBO Rep. 18 (6) 526-535 (2017). doi

Schumacher, D., Bergeler, S., Harms, A., Vonck, J., Huneke-Vogt, S., Frey, E., and Søgaard-Andersen: The PomXYZ Proteins Self-Organize on the Bacterial Nucleoid to Stimulate Cell Division.
Dev. Cell 41 299-314 (2017). doi

van Pee, K., Neuhaus, A., D'Imprima, E., Mills, D. J., Kühlbrandt, W., and Yildiz, Ö.: CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin.
eLife 22 pp., doi: 10.7554/eLife.23644 (2017). online

Vonck, J. and Mills, D. J.: Advances in high-resolution cryo-EM of oligomeric enzymes.
Curr. Opin. Struct. Biol. 46 48-54 (2017). doi

Weston, C. E., Krämer, A., Colin, F., Yildiz, Ö., Baud, M. G. J., Meyer-Almes, F.-J., and Fuchter, M. J.: Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors.
ACS Infect. Dis. 3 (2) 152-161 (2017). doi

Wilkes, M., Madej, M. G., Kreuter, L., Rhinow, D., Heinz, V., De Sanctis, S., Ruppel, S., Richter, R. M., Joos, F., Grieben, M., Pike, A. C. W., Huiskonen, J. T., Carpenter, E. P., Kühlbrandt, W., Witzgall, R., and Ziegler, C.: Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2.
Nat. Struct. Mol. Biol. 24 (2) 123-130, doi: 10.1038/nsmb.3357 (2017). online

Ph. D. Theses

Alexander Mühleip: Tomographic studies of mitochondrial membrane-shaping proteins.
Goethe-Universität, Frankfurt am Main, 2017

David Wöhlert: Structures and mechanism of secondary active transporters.
Goethe-Universität, Frankfurt am Main, 2017.

Master's Theses

Natalie Bärland
Goethe-Universität, Frankfurt am Main, 2017.

Jessica Michelle Devant
Goethe-Universität, Frankfurt am Main, 2017.

Christian Diwo
Fachhochschule Kärnten, Österreich, 2017.

Sebastian Kempf
Goethe-Universität, Frankfurt am Main, 2017.

Nina Salustros
Goethe-Universität, Frankfurt am Main, 2017.

Oliver Stach
Goethe-Universität, Frankfurt am Main, 2017.

Bachelor's Theses

Clara Börnsen
Goethe-Universität, Frankfurt am Main, 2017.

Pia Fischer
Goethe-Universität, Frankfurt am Main, 2017.

Lisa Klatt
Goethe-Universität, Frankfurt am Main, 2017.

Chiara Lichtenthäler
Goethe-Universität, Frankfurt am Main, 2017.

Kontaktinformationen:

Max-Planck-Institut für Biophysik

Prof. Dr. Werner Kühlbrandt, Direktor
Abteilung für Strukturbiologie
Sekretariat: Monika Hobrack

Tel.: +49 (0) 69 6303-3001
Fax: +49 (0) 69 6303-3002
E-Mail: monika.hobrack(at)biophys.mpg.de