Publikationen der Zentrale EM-Facility

Schulz, V.; Steinhilper, R.; Oltmanns, J.; Freibert, S.-A.; Krapoth, N.; Linne, U.; Welsch, S.; Hoock, M. H.; Schünemann, V.; Murphy, B. J. et al.; Lill, R.: Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2. Nature Communications 15, 3269 (2024)

Aziz, I.; Kayastha, K.; Kaltwasser, S.; Vonck, J.; Welsch, S.; Murphy, B. J.; Kahnt, J.; Wu, D.; Wagner, T.; Shima, S. et al.; Ermler, U.: Structural and mechanistic basis of the central energy-converting methyltransferase complex of methanogenesis. PNAS 121 (14), e2315568121 (2024)

Liu, J.; Corroyer-Dulmont, S.; Pražák, V.; Khusainov, I.; Bahrami, K.; Welsch, S.; Vasishtan, D.; Obarska-Kosińska, A.; Thorkelsson, S. R.; Grünewald, K. et al.; Quemin, E. R. J.; Turoňová, B.; Locker, J. K.: The palisade layer of the poxvirus core is composed of flexible A10 trimers. Nature Structural & Molecular Biology (2024)

Schmidt, F. V.; Schulz, L.; Zarzycki, J.; Prinz, S.; Oehlmann, N. N.; Erb, T. J.; Rebelein, J. G.: Structural insights into the iron nitrogenase complex. Nature Structural & Molecular Biology 31 (1), S. 150 - 158 (2024)

Marchal, D. G.; Schulz, L.; Schuster, I.; Ivanovska, J.; Paczia, N.; Prinz, S.; Zarzycki, J.; Erb, T. J.: Machine Learning-Supported Enzyme Engineering toward Improved CO₂-Fixation of Glycolyl-CoA Carboxylase. ACS Synthetic Biology 12 (12), S. 3521 - 3530 (2023)

Hau, J.-L.; Kaltwasser, S.; Muras, V.; Casutt, M. S.; Vohl, G.; Claußen, B.; Steffen, W.; Leitner, A.; Bill, E.; Cutsail, G. E. et al.; DeBeer, S.; Vonck, J.; Steuber, J.; Fritz, G.: Conformational coupling of redox-driven Na⁺-translocation in Vibrio cholerae NADH:quinone oxidoreductase. Nature Structural & Molecular Biology 30 (11), S. 1686 - 1694 (2023)

Wu, D.; Mehdipour, A. R.; Finke, F.; Goojani, H. G.; Groh, R. R.; Grund, T. N.; Reichhart, T. M. B.; Zimmermann, R.; Welsch, S.; Bald, D. et al.; Shepherd, M.; Hummer, G.; Safarian, S.: Dissecting the conformational complexity and mechanism of a bacterial heme transporter. Nature Chemical Biology 19 (8), S. 992 - 1003 (2023)

Xing, H.; Taniguchi, R.; Khusainov, I.; Kreysing, J. P.; Welsch, S.; Turoňová, B.; Beck, M.: Translation dynamics in human cells visualized at high resolution reveal cancer drug action. Science 381 (6653), S. 70 - 75 (2023)

Winiarska, A.; Ramírez-Amador, F.; Hege, D.; Gemmecker, Y.; Prinz, S.; Hochberg, G.; Heider, J.; Szaleniec, M.; Schuller, J. M.: A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire. Science Advances 9, eadg6689 (2023)

Xie, H.; Lyratzakis, A.; Khera, R.; Koutantou, M.; Welsch, S.; Michel, H.; Tsiotis, G.: Cryo-EM structure of the whole photosynthetic reaction center apparatus from the green sulfur bacterium Chlorobaculum tepidum. Proceedings of the National Academy of Sciences of the United States of America 120 (5), e2216734120 (2023)

Grund, T. N.; Kabashima, Y.; Kusumoto, T.; Wu, D.; Welsch, S.; Sakamoto, J.; Michel, H.; Safarian, S.: The cryoEM structure of cytochrome bd from C. glutamicum provides novel insights into structural properties of actinobacterial terminal oxidases. Frontiers in Chemistry (2023)

Hoffmann, P. C.; Kreysing, J. P.; Khusainov, I.; Tuijtel, M.; Welsch, S.; Beck, M.: Structures of the eukaryotic ribosome and its translational states in situ. Nature Communications 13, 7435 (2022)

Schleker, E. S. M.; Buschmann, S.; Xie, H.; Welsch, S.; Michel, H.; Reinhart, C.: Structural and functional investigation of ABC transporter STE6-2p from Pichia pastoris reveals unexpected interaction with sterol molecules. Proceedings of the National Academy of Sciences of the United States of America 126 (43), S. 8646 - 8654 (2022)

Schulz, L.; Guo, Z.; Zarzycki, J.; Steinchen, W.; Schuller, J. M.; Heimerl, T.; Prinz, S.; Mueller-Cajar, O.; Erb, T. J.; Hochberg, G. K. A.: Evolution of increased complexity and specificity at the dawn of form I Rubiscos. Science 378 (6616), S. 155 - 160 (2022)

Khera, R.; Mehdipour, A. R.; Bolla, J. R.; Kahnt, J.; Welsch, S.; Ermler, U.; Münke, C.; Robinson, C. V.; Hummer, G.; Xie, H. et al.; Michel, H.: Cryo-EM structures of pentameric autoinducer-2 exporter from Escherichia coli reveal its transport mechanism. The EMBO Journal 41 (18), e109990 (2022)

Kayastha, K.; Katsyv, A.; Himmrich, C.; Welsch, S.; Schuller, J. M.; Ermler, U.; Müller, V.: Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex. eLife 11, e77095 (2022)

Aziz, I.; Kaltwasser, S.; Kayastha, K.; Khera, R.; Vonck, J.; Ermler, U.: The molybdenum storage protein forms and deposits distinct polynuclear tungsten oxygen aggregates. Journal of Inorganic Biochemistry 234, 111904 (2022)

Grund, T. N.; Radloff, M.; Wu, D.; Goojani, H. G.; Witte, L. F.; Jösting, W.; Buschmann, S.; Müller, H.; Elamri, I.; Welsch, S. et al.; Schwalbe, H.; Michel, H.; Bald, D.; Safarian, S.: Mechanistic and structural diversity between cytochrome bd isoforms of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America 118 (50), e2114013118 (2021)

Kolbe, F.; Safarian, S.; Piórek, Ż.; Welsch, S.; Müller, H.; Michel, H.: Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase. Nature Communications 12, 6903 (2021)

Safarian, S.; Opel-Reading, H. K.; Wu, D.; Mehdipour, A. R.; Hards, K.; Harold, L. H.; Radloff, M.; Stewart, I.; Welsch, S.; Hummer, G. et al.; Cook, G. M.; Krause, K. L.; Michel, H.: The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB. Nature Communications 12 (1), 5236 (2021)

Ebenhoch, R.; Prinz, S.; Kaltwasser, S.; Mills, D. J.; Meinecke, R.; Rübbelke, M.; Reinert, D.; Bauer, M.; Weixler, L.; Zeeb, M. et al.; Vonck, J.; Nar, H.: A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proceedings of the National Academy of Sciences of the United States of America 117 (50), S. 31838 - 31849 (2020)

Chowdhury, N. P.; Alberti, L.; Linder, M.; Müller, V.: Exploring Bacterial Microcompartments in the Acetogenic Bacterium Acetobacterium woodii. Frontiers in Microbiology 11, 593467 (2020)

Turoňová, B.; Sikora, M.; Schürmann, C.; Hagen, W. J. H.; Welsch, S.; Blanc, F. E. C.; von Bülow, S.; Gecht, M.; Bagola, K.; Hörner, C. et al.; van Zandbergen, G.; Landry, J.; de Azevedo, N. T. D.; Mosalaganti, S.; Schwarz, A.; Covino, R.; Mühlebach, M. D.; Hummer, G.; Krijnse Locker, J.; Beck, M.: In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges. Science 370 (6513), S. 203 - 208 (2020)

Wu, D.; Grund, T. N.; Welsch, S.; Mills, D.; Michel, M.; Safarian, S.; Michel, H.: Structural basis for amino acid exchange by a human heteromeric amino acid transporter. Proceedings of the National Academy of Sciences of the United States of America 117 (35), 202008111, S. 21281 - 21287 (2020)

Vitt, S.; Prinz, S.; Hellwig, N.; Morgner, N.; Ermler, U.; Buckel, W.: Molecular and Low-Resolution Structural Characterization of the Na+-Translocating Glutaconyl-CoA Decarboxylase From Clostridium symbiosum. Frontiers in Microbiology 11, 480 (2020)

Parey, K.; Haapanen, O.; Sharma, V.; Köfeler, H.; Züllig, T.; Prinz, S.; Siegmund, K.; Wittig, I.; Mills, D.; Vonck, J. et al.; Kühlbrandt, W.; Zickermann, V.: High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease. Science Advances 5 (12), S. eaax9484 (2019)

Akram, M.; Dietl, A.; Mersdorf, U.; Prinz, S.; Maalcke, W. J.; Keltjens, J. T.; Ferousi, C.; de Almeida, N. M.; Reimann, J.; Kartal, B. et al.; Jetten, M. S. M.; Parey, K.; Barends, T.: A 192-heme electron transfer network in the hydrazine dehydrogenase complex. Science Advances 5 (4), eaav4310 (2019)

Payer, S. E.; Marshall, S. A.; Bärland, N.; Sheng, X.; Reiter, T.; Dordic, A.; Steinkellner, G.; Wuensch, C.; Kaltwasser, S.; Fisher, K. et al.; Rigby, S. E. J.; Macheroux, P.; Vonck, J.; Gruber, K.; Faber, K.; Himo, F.; Leys, D.; Pavkov-Keller, T.; Glueck, S. M.: Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase. Angewandte Chemie, International Edition in English 56 (44), S. 13893 - 13897 (2017)

Călinescu, O.; Linder, M.; Wöhlert, D.; Yildiz, Ö.; Kühlbrandt, W.; Fendler, K.: Electrogenic Cation Binding in the Electroneutral Na⁺/H⁺ Antiporter of Pyrococcus abyssi. The Journal of Biological Chemistry 291 (52), S. 26786 - 26793 (2016)