Publikationen der Langer Gruppe
Membranproteomik und Mass Spektrometrie

Natriashvili, A.; Mohammadsadeghi, N.; Milanov, M.; Smudde, E.; Prucker, I.; Jessen, H. J.; Carabadjac, I.; Heerklotz, H.; Franco, P. H. C.; Langer, J. D. et al.; Koch, H.-G.: Metabolic silencing induced by the small bacterial membrane protein YohP. iScience 28 (12), 114123 (2025)

Yang, T.-J.; Mukherjee, S.; Langer, J. D.; Hummer, G.; McDowell, M. A.: SND3 is the membrane insertase within a distinct SEC61 translocon complex. Nature Communications 16, 9566 (2025)

Bresciani, V.; Rinaldi, F.; Franco, P.; Girotto, S.; Cavalli, A.; Langer, J. D.; Masetti, M.; Bernetti, M.: Dissecting the RAD51–BRC4 Interaction Landscape through Integrative Molecular Simulations and Experimental Biophysics. Journal of Chemical Information and Modeling 65 (21), S. 11965 - 11978 (2025)

Manger, S.; Arghittu, S. M.; Sprankel, L.; Meier-Credo, J.; Wieland, K.; Bublak, D.; Langer, J. D.; Covino, R.; Frangakis, A. S.: How does Mycoplasma pneumoniae scavenge lipids from its host membranes? Science Advances 11 (40), eady4746 (2025)

Brdar, A.; Osterburg, C.; Münick, P.; Machel, A. C.; Rathore, R.; Osterburg, S.; Yüksel, B.; Schäfer, B.; Desch, K.; Langer, J. D. et al.; Dikic, I.; Dötsch, V.: p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners. eLife 13, RP103537 (2025)

Zeinert, R.; Zhou, F.; Franco, P.; Zöller, J.; Madni, Z. K.; Lessen, H.; Aravind, L.; Langer, J. D.; Sodt, A. J.; Storz, G. et al.; Matthies, D.: P-type ATPase magnesium transporter MgtA acts as a dimer. Nature Structural & Molecular Biology 32 (9), S. 1633 - 1643 (2025)

Kaulich, E.; Waselenchuk, Q.; Fürst, N.; Desch, K.; Mosbacher, J.; Ciirdaeva, E.; Juengling, M.; Ray, R.; Nassim-Assir, B.; Tushev, G. et al.; Langer, J. D.; Schuman, E. M.: An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution. Nature Communications 16, 7942 (2025)

Franco, P. H. C.; Zeinert, R.; Meier-Credo, J.; Storz, G.; Langer, J. D.: Detection and Quantitation of Small Proteins Using Mass Spectrometry. Molecular & Cellular Proteomics 24 (9), 101052 (2025)

Ros, U.; Martinez-Osorio, V.; Valiente, P. A.; Abdelwahab, Y.; Gojkovic, M.; Shalaby, R.; Zanna, S.; Saggau, J.; Wachsmuth, L.; Nemade, H. N. et al.; Zoeller, J.; Lottermoser, H.; Chen, Y.-G.; Ibrahim, M.; Kelepouras, K.; Vasilikos, L.; Bedoya, P.; Espiritu, R. A.; Müller, S.; Altmannova, V.; Tieleman, D. P.; Weir, J.; Langer, J. D.; Adam, M.; Walczak, H.; Wong, W. W.-L.; Liccardi, G.; Mollenhauer, M.; Pasparakis, M.; Peltzer, N.; García-Sáez, A. J.: MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Molecular Cell 85 (8), S. 1589 - 1605 (2025)

Bailey, H. J.; Eisert, J.; Kazi, R.; Gerhartz, J.; Pieńkowska, D. E.; Dressel, I.; Vollrath, J.; Kondratov, I.; Matviyuk, T.; Tolmachova, N. et al.; Shah, V. J.; Giuliani, G.; Mosler, T.; Geiger, T. M.; Esteves, A. M.; Santos, S. P.; Sousa, R. L.; Bandeiras, T. M.; Leibrock, E.-M.; Bauer, U.; Leuthner, B.; Langer, J. D.; Wegener, A. A.; Nowak, R. P.; Sorrell, F. J.; Đikić, I.: An engineered cereblon optimized for high throughput screening and molecular glue discovery. Cell Chemical Biology 32 (2), S. 363 - 376.e10 (2025)

Karimi, K.; Zöller, J.; Hofmann, T.; Zangl, R.; Schulte, J.; Langer, J. D.; Schmidt, C.; Morgner, N.: MS SIEVE – Pushing the Limits for Biomolecular Mass Spectrometry. Journal of the American Society for Mass Spectrometry 36 (1), S. 91 - 99 (2025)

Herhaus, L.; Gestal-Mato, U.; Eapen, V. V.; Mačinković, I.; Bailey, H. J.; Prieto-Garcia, C.; Misra, M.; Jacomin, A.-C.; Ammanath, A. V.; Bagarić, I. et al.; Michaelis, J.; Vollrath, J.; Bhaskara, R. M.; Bündgen, G.; Covarrubias-Pinto, A.; Husnjak, K.; Zöller, J.; Gikandi, A.; Ribičić, S.; Bopp, T.; van der Heden van Noort, G. J.; Langer, J. D.; Weigert, A.; Harper, J. W.; Mancias, J. D.; Đikić, I.: IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion. Cell 187 (7), S. 7285 - 7302 (2024)

Laub, V.; Nan, E.; Elias, L.; Donaldson, I. J.; Bentsen, M.; Rusling, L. A.; Schupp, J.; Lun, J. H.; Plate, K. H.; Looso, M. et al.; Langer, J. D.; Günther, S.; Bobola, N.; Schulte, D.: Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4. Nucleic Acids Research 52 (20), gkae864, S. 12262 - 12280 (2024)

Kuhn, B. T.; Zöller, J.; Zimmermann, I.; Gemeinhardt, T.; Özkul, D. H.; Langer, J. D.; Seeger, M. A.; Geertsma, E. R.: Interdomain-linkers control conformational transitions in the SLC23 elevator transporter UraA. Nature Communications 15, 7518 (2024)

Khusainov, I.; Romanov, N.; Goemans, C.; Turoňová, B.; Zimmerli, C. E.; Welsch, S.; Langer, J. D.; Typas, A.; Beck, M.: Bactericidal effect of tetracycline in E. coli strain ED1a may be associated with ribosome dysfunction. Nature Communications 15, 4783 (2024)

Adolph, C.; Cheung, C.-Y.; McNeil, M. B.; Jowsey, W. J.; Williams, Z. C.; Hards, K.; Harold, L. K.; Aboelela, A.; Bujaroski, R. S.; Buckley, B. J. et al.; Tyndall, J. D. A.; Li, Z.; Langer, J. D.; Preiss, L.; Meier, T.; Steyn, A. J. C.; Rhee, K. Y.; Berney, M.; Kelso, M. J.; Cook, G. M.: A dual-targeting succinate dehydrogenase and F₁F_o-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chemical Biology 31, S. 683 - 698.e7 (2024)

Altincekic, N.; Jores, N.; Löhr, F.; Richter, C.; Ehrhardt, C.; Blommers, M. J. J.; Berg, H.; Öztürk, S.; Gande, S. L.; Linhard, V. et al.; Orts, J.; Abi Saad, M. J.; Bütikofer, M.; Kaderli, J.; Karlsson, B. G.; Brath, U.; Hedenström, M.; Gröbner, G.; Sauer, U. H.; Perrakis, A.; Langer, J. D.; Banci, L.; Cantini, F.; Fragai, M.; Grifagni, D.; Barthel, T.; Wollenhaupt, J.; Weiss, M. S.; Robertson, A.; Bax, A.; Sreeramulu, S.; Schwalbe, H.: Targeting the Main Protease (M^pro, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS Chemical Biology 19 (2), S. 563 - 574 (2024)

Bapat, O.; Purimetla, T.; Kruessel, S.; Shah, M.; Fan, R.; Thum, C.; Rupprecht, F. A.; Langer, J. D.; Rangaraju, V.: VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity. Nature Communications 15 (1), 205 (2024)

van Oostrum, M.; Blok, T. M.; Giandomenico, S. L.; tom Dieck, S.; Tushev, G.; Fürst, N.; Langer, J. D.; Schuman, E. M.: The proteomic landscape of synaptic diversity across brain regions and cell types. Cell 186 (24), S. 5411 - 5427.e23 (2023)

Meier-Credo, J.; Heiniger, B.; Schori, C.; Rupprecht, F.; Michel, H.; Ahrens, C. A.; Langer, J. D.: Detection of Known and Novel Small Proteins in Pseudomonas stutzeri Using a Combination of Bottom-Up and Digest-Free Proteomics and Proteogenomics. Analytical Chemistry 95, S. 11892 - 11900 (2023)