Publikationen der Abteilung für Theoretische Biophysik (TB)

Anastasia, C. M.; Paul, S.; Kim, H.-I.; Cui, Q.; Fairbrother, D. H.; Giraldo, J. P.: Size and Cross-Linking Dependent Gold Nanoparticle Interactions with Dynamic Pectin Model Plant Cell Walls. ACS Nano (2026)

Lapenta, F.; Palacio Rodríguez, K.; Cruz-León, S.; Marrancone, S.; Aupič, J.; Marechal, N.; Durand, A.; Moussaoui, D.; Covaceuszach, S.; Gangupam, B. et al.; D'Ercole, C.; Parra, C.; Cotugno, D.; Tomaino, G.; Tortora, P.; de Marco, A.; Cassetta, A.; Magistrato, A.; Hummer, G.: Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations. Nature Communications (2026)

Azeez, K. R. A.; Saraswati, H.; Mosler, T.; Hanke, T.; Ho-Xuan, H.; Neder, N.; Sivashanmugam, S. A.; Heinz, M.; Schwalm, M.-P.; Giuliani, G. et al.; Rathore, R.; Kazi, R.; Kumar, R.; Mitrovic, M.; Prieto-Garcia, C.; Bailey, H. J.; Mathea, S.; Hummer, G.; Đikić, I.; Müller, S.; Stolz, A.; Krause, D. S.; Knapp, S.: Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader. ACS Chemical Biology 21 (5), S. 1158 - 1176 (2026)

Geißler, K.; Kreysing, J. P.; Wang, Y.; Glushkova, D.; Obarska-Kosinska, A.; Hoffmann, P. C.; Böhm, S.; Schmidt, A.; Meier-Credo, J.; Langer, J. D. et al.; Hummer, G.; Beck, M.: The vault associates with membranes in situ. Nature Communications 17, 3659 (2026)

Neuhaus, A.; McLaren, M.; Isupov, M. N.; Gaines, M.; Buzzard, E.; Sikora, M.; Hanus, C.; Daum, B.; Averhoff, B.; Gold, V. A. M.: Structural insights into the Thermus thermophilus type IV pilus machinery assembling two distinct pili. Communications Biology 9, 474 (2026)

Ibrahim, M.; Köfinger, J.; Zacharias, M.; Schneck, E.; Schwierz, N.: RNA at Lipid/Water Interfaces: Molecular Insights from Coarse-Grained Simulations and Reflectivity Data Predictions. Langmuir 42 (12), S. 8443 - 8452 (2026)

Debnath, J.; Hummer, G.: Random Functions as Data Compressors for Machine Learning of Molecular Processes. Journal of Chemical Theory and Computation 22 (3), S. 1504 - 1513 (2026)

Storm, K. R.; Wiebeler, C.; Cruz-León, S.; Körösy, C.; Schwierz, N.; Lipfert, J.: DNA twist at high alkali ion concentrations: evidence against C-form DNA in solution. Nucleic Acids Research 54 (5), gkag192 (2026)

Tesmer, L.; Matter, H.; Klingler, O.; Schudok, M.; Hessler, G.; Mehdipour, A. R.; Güssregen, S.; Schreuder, H.; Hummer, G.: Nonstandard Factor VIIa Binding Mode Reveals S1 Pocket Plasticity in Trypsin-Like Proteases. ChemMedChem 21 (2), e202500846 (2026)

Schäfer, D.; Prieto-Garcia, C.; Wang, J.; Heinz, M.; Matkovic, V.; Kielkowski, P.; Hasselbeck, S.; Shah, V. J.; Knapp, S.; Hummer, G. et al.; Dikic, I.; Cheng, X.: Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation. Angewandte Chemie (International Ed. in English) 65 (5), e16809 (2026)

Paul, S.: Integrative Multiscale Simulations Uncover the Mechanistic Principles Governing COPII Mediated Vesicle Formation. The Journal of Membrane Biology 259 (1), 1 (2026)

Post, M.; Hummer, G.: AI-guided transition path sampling of lipid flip-flop and membrane nanoporation. Nature Communications 17, 224 (2026)

Rosenkranz, N.; Birtasu, A. N.; Wieland, K.; Rehm, L.; Sharma, R.; Vats, A.; Manger, S.; Srivastava, A.; Bhattacharya, A.; Hummer, G. et al.; Frangakis, A. S.; Gottschalk, A.: In situ structure of a gap junction-stomatin complex. Science Advances 11 (45), eaea8596 (2025)

Mondal, S.; Mukherjee, S.; Namitz, K. E. W.; Yennawar, N. H.; Boehr, D. D.: Multivalent Interactions Between the Picornavirus 3C(D) Main Protease and RNA Oligonucleotides Induce Liquid-Liquid Phase Separation. Viruses 17 (11), 1473 (2025)

Yang, T.-J.; Mukherjee, S.; Langer, J. D.; Hummer, G.; McDowell, M. A.: SND3 is the membrane insertase within a distinct SEC61 translocon complex. Nature Communications 16, 9566 (2025)

Langschied, F.; Iruegas, R.; Sikora, M.; Covino, R.; Ebersberger, I.: A Multi-level Perspective on the Evolution of Orthologs and Their Functions. Journal of Molecular Evolution 93, S. 720 - 729 (2025)

Majtner, T.; Kreysing, J. P.; Tuijtel, M.; Cruz-León, S.; Liu, J.; Hummer, G.; Beck, M.; Turoňová, B.: cryoTIGER: deep-learning based tilt interpolation generator for enhanced reconstruction in cryo electron tomography. Communications Biology 8, 1443 (2025)

Hasselbeck, S.; Wang, J.; Bai, Z.; Hüfner, T.; Hummer, G.; Grote, P.; Cheng, X.: A Chemically Induced CRISPR/dCas13^FCPF Platform for Precise and Programmable RNA Regulation. Journal of Medicinal Chemistry 68, S. 22633 - 22649 (2025)

Ho-Xuan, H.; Bruckmann, A.; Natali, L.; Prieto-Garcia, C.; Stuke, J. F. M.; Brunello, L.; Vicente, A.; Pfab, A.; Wesseling, H.; Cano-Franco, S. et al.; Khatri, A.; Larivera, S.; Sanz-Martinez, P.; de la Cruz-Thea, B.; Jacomin, A.-C.; Prochazka, J.; Feederle, R.; Dötsch, V.; Sedlacek, R.; Hummer, G.; Kaiser, S.; Dikic, I.; Musri, M. M.; Meister, G.; Stolz, A.: YTHDF proteins and m⁶A-RNA clients undergo autophagic turnover during contact inhibition. Cell Reports 44 (9), 116188 (2025)

Fábián, B.; Stuke, J. F. M.; Heinz, M.; Hummer, G.: AlphaFold modeling of polyubiquitin complexes and covalently linked proteins. Cell Reports Physical Science 6 (9), 102796 (2025)