Publikationen von Florian Wilfling

Zeitschriftenartikel (36)

2025
Zeitschriftenartikel
Licheva, M.; Babic, R.; Pflaum, J.; Mancilla, H.; Wilfling, F.; Kraft, C.: To degrade or not to degrade: how phase separation modulates selective autophagy. Autophagy (2025)
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Licheva, M.; Pflaum, J.; Babic, R.; Mancilla, H.; Elsässer, J.; Boyle, E.; Hollenstein, D. M.; Jimenez-Niebla, J.; Pleyer, J.; Heinrich, M. et al.; Wieland, F.-G.; Brenneisen, J.; Eickhorst, C.; Brenner, J.; Jiang, S.; Hartl, M.; Welsch, S.; Hunte, C.; Timmer, J.; Wilfling, F.; Kraft, C.: Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy. Nature Cell Biology 27 (2), S. 283 - 297 (2025)
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Kraus, F.; He, Y.; Swarup, S.; Overmyer, K. A.; Jiang, Y.; Brenner, J.; Capitanio, C.; Bieber, A.; Jen, A.; Nightingale, N. M. et al.; Anderson, B. J.; Lee, C.; Paulo, J. A.; Smith, I. R.; Plitzko, J. M.; Gygi, S. P.; Schulman, B. A.; Wilfling, F.; Coon, J. J.; Harper, J. W.: Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST. Science Advances 11 (4), eadu5787 (2025)
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2024
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Grizel, A. V.; Gorsheneva, N. A.; Stevenson, J. B.; Pflaum, J.; Wilfling, F.; Rubel, A. A.; Chernoff, Y. O.: Osmotic stress induces formation of both liquid condensates and amyloids by a yeast prion domain. Journal of Biological Chemistry 300 (10), 107766 (2024)
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Lizarrondo, J.; Wilfling, F.: Selective autophagy of macromolecular complexes: what does it take to be taken? Journal of Molecular Biology 436, 168574 (2024)
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Wilfling, F.; Graef, M.: Molecular Mechanisms and Physiological Functions of Autophagy. Journal of Molecular Biology 436, 168692 (2024)
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Zhao, D. Y.; Bäuerlein, F. J. B.; Saha, I.; Hartl, F. U.; Baumeister, W.; Wilfling, F.: Autophagy preferentially degrades non-fibrillar polyQ aggregates. Molecular Cell 84 (10), S. 1980 - 1994.e8 (2024)
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Hoyer, M. J.; Capitanio, C.; Smith, I. R.; Paoli, J. C.; Bieber, A.; Jiang, Y.; Paulo, J. A.; Gonzalez-Lozano, M. A.; Baumeister, W.; Wilfling, F. et al.; Schulman, B. A.; Harper, J. W.: Combinatorial selective ER-phagy remodels the ER during neurogenesis. Nature Cell Biology 26 (3), S. 378 - 392 (2024)
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2023
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Wilfling, F.; Kaksonen, M.; Stachowiak, J.: Protein condensates as flexible platforms for membrane traffic. Current Opinion in Cell Biology 85, 102258 (2023)
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Boyle, E.; Wilfling, F.: Autophagy as a caretaker of nuclear integrity. FEBS Letters 597, S. 2728 - 2738 (2023)
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Brenner, J.; Klumpe, S.; Wilfling, F.; Plitzko, J. M.: Towards Temporal Resolution in Correlative Cryo-electron Tomography. Microscopy and Microanalysis 29 (Supplement\1), S. 1937 - 1938 (2023)
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Schmitt, D.; Bozkurt, S.; Henning-Domres, P.; Huesmann, H.; Eimer, S.; Bindila, L.; Behrends, C.; Boyle, E.; Wilfling, F.; Tascher, G. et al.; Münch, C.; Behl, C.; Kern, A.: FACS-mediated isolation of native autophagic vesicles. Autophagy 19 (7), S. 2146 - 2147 (2023)
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Capitanio, C.; Bieber, A.; Wilfling, F.: How Membrane Contact Sites Shape the Phagophore. Contact 6 (2023)
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Li, M.; Tripathi-Giesgen, I.; Schulman, B. A.; Baumeister, W.; Wilfling, F.: In situ snapshots along a mammalian selective autophagy pathway. Proceedings of the National Academy of Sciences of the United States of America 120 (12), e2221712120 (2023)
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2022
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Schmitt, D.; Bozkurt, S.; Henning-Domres, P.; Huesmann, H.; Eimer, S.; Bindila, L.; Behrends, C.; Boyle, E.; Wilfling, F.; Tascher, G. et al.; Münch, C.; Behl, C.; Kern, A.: Lipid and protein content profiling of isolated native autophagic vesicles. EMBO Reports, e53065 (2022)
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Bieber, A.; Capitanio, C.; Erdmann, P. S.; Fiedler, F.; Beck, F.; Lee, C.-W.; Li, D.; Hummer, G.; Schulman, B. A.; Baumeister, W. et al.; Wilfling, F.: In situ structural analysis reveals membrane shape transitions during autophagosome formation. Proceedings of the National Academy of Sciences of the United States of America 119 (39), e2209823119 (2022)
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Enenkel, C.; Kang, R. W.; Wilfling, F.; Ernst, O. P.: Intracellular localization of the proteasome in response to stress conditions. The Journal of Biological Chemistry 298 (7), 102083 (2022)
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Qiao, S.; Lee, C.-W.; Sherpa, D.; Chrustowicz, J.; Cheng, J.; Duennebacke, M.; Steigenberger, B.; Karayel, O.; Vu, D. T.; von Gronau, S. et al.; Mann, M.; Wilfling, F.; Schulman, B. A.: Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation. Nature Communications 13, 3041 (2022)
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Boyle, E.; Wilfling, F.: Bypassing the nuclear gate: A non-canonical entry pathway for the mitochondrial pyruvate dehydrogenase complex. Molecular Cell 82 (5), S. 886 - 888 (2022)
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2021
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Bieber, A.; Capitanio, C.; Wilfling, F.; Plitzko, J.; Erdmann, P. S.: Sample Preparation by 3D-Correlative Focused Ion Beam Milling for High-Resolution Cryo-Electron Tomography. Journal of Visualized Experiments (176), e62886 (2021)
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Wilfling, F.; Lee, C.-W.; Erdmann, P. S.; Baumeister, W.: Autophagy ENDing unproductive phase-separated endocytic protein deposits. Autophagy 17 (10), S. 3264 - 3265 (2021)
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Erdbrügger, P.; Wilfling, F.: p62 condensates are a hub for proteasome-mediated protein turnover in the nucleus. Proceedings of the National Academy of Sciences of the United States of America 118 (37), e2113647118 (2021)
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Erdmann, P. S.; Hou, Z.; Klumpe, S.; Khavnekar, S.; Beck, F.; Wilfling, F.; Plitzko, J. M.; Baumeister, W.: In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli. Nature Communications 12 (1), 5364 (2021)
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2020
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Wilfling, F.; Lee, C.-W.; Erdmann, P. S.; Zheng, Y.; Sherpa, D.; Jentsch, S.; Pfander, B.; Schulman, B. A.; Baumeister, W.: A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits. Molecular Cell 80 (5), S. 764 - 778 (2020)
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Bittmann, J.; Grigaitis, R.; Galanti, L.; Amarell, S.; Wilfling, F.; Matos, J.; Pfander, B.: An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases. eLife 9, e52459 (2020)
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Lee, C.-W.; Wilfling, F.; Ronchi, P.; Allegretti, M.; Mosalaganti, S.; Jentsch, S.; Beck, M.; Pfander, B.: Selective autophagy degrades nuclear pore complexes. Nature Cell Biology 22 (2), S. 159 - 166 (2020)
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2015
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Frank, D. O.; Dengjel, J.; Wilfling, F.; Kozjak-Pavlovic, V.; Häcker, G.; Weber, A.: The Pro-Apoptotic BH3-Only Protein Bim Interacts with Components of the Translocase of the Outer Mitochondrial Membrane (TOM). PLoS One 10 (4), e0123341 (2015)
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2014
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Wilfling, F.; Haas, J. T.; Walther, T. C.; Farese, R. V.: Lipid droplet biogenesis. Current Opinion in Cell Biology 29, S. 39 - 45 (2014)
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Wilfling, F.; Thiam, A. R.; Olarte, M.-J.; Wang, J.; Beck, R.; Gould, T. J.; Allgeyer, E. S.; Pincet, F.; Bewersdorf, J.; Farese, R. V. et al.; Walther, T. C.: Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. eLife 3, e01607 (2014)
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2013
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Thiam, A. R.; Antonny, B.; Wang, J.; Delacotte, J.; Wilfling, F.; Walther, T. C.; Beck, R.; Rothman, J. E.; Pincet, F.: COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function. Proceedings of the National Academy of Sciences of the United States of America 110 (33), S. 13244 - 13249 (2013)
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Mejhert, N.; Wilfling, F.; Esteve, D.; Galitzky, J.; Pellegrinelli, V.; Kolditz, C.-I.; Viguerie, N.; Tordjman, J.; Näslund, E.; Trayhurn, P. et al.; Lacasa, D.; Dahlman, I.; Stich, V.; Lång, P.; Langin, D.; Bouloumié, A.; Clément, K.; Rydén, M.: Semaphorin 3C is a novel adipokine linked to extracellular matrix composition. Diabetologia 56 (8), S. 1792 - 1801 (2013)
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Krahmer, N.; Hilger, M.; Kory, N.; Wilfling, F.; Stoehr, G.; Mann, M.; Farese Jr., R. V.; Walther, T. C.: Protein Correlation Profiles Identify Lipid Droplet Proteins with High Confidence. Molecular and Cellular Proteomics 12 (5), S. 1115 - 1126 (2013)
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Wilfling, F.; Wang, H.; Haas, J. T.; Krahmer, N.; Gould, T. J.; Uchida, A.; Cheng, J.-X.; Graham, M.; Christiano, R.; Fröhlich, F. et al.; Liu, X.; Buhman, K. K.; Coleman, R. A.; Bewersdorf, J.; Farese, R. V.; Walther, T. C.: Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Developmental Cell 24 (4), S. 384 - 399 (2013)
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2012
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Wilfling, F.; Weber, A.; Potthoff, S.; Vögtle, F.-N.; Meisinger, C.; Paschen, S. A.; Häcker, G.: BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax. Cell Death and Differentiation 19 (8), S. 1328 - 1336 (2012)
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2011
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Krahmer, N.; Guo, Y.; Wilfling, F.; Hilger, M.; Lingrell, S.; Heger, K.; Newman, H. W.; Schmidt-Supprian, M.; Vance, D. E.; Mann, M. et al.; Farese, R. V.; Walther, T. C.: Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metabolism 14 (4), S. 504 - 515 (2011)
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2007
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Weber, A.; Paschen, S. A.; Heger, K.; Wilfling, F.; Frankenberg, T.; Bauerschmitt, H.; Seiffert, B. M.; Kirschnek, S.; Wagner, H.; Häcker, G.: Bims-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins. The Journal of Cell Biology: JCB 177 (4), S. 625 - 636 (2007)
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