Max-Planck-Institut für Biophysik

Publikationen des Max-Planck-Institutes für Biophysik

Publikationen des Max-Planck-Institutes für Biophysik

Zeitschriftenartikel (3304)

2026

Zeitschriftenartikel

Segundo-Acosta, P. S.; Nomura, S.; Fernandes-Queiroz, J. P.; Protasov, E.; Kahnt, J.; Kaneko, M.; Hochberg, G.; Shima, S.; Murphy, B. J.: Diversity of electron-bifurcating CO₂-fixing supercomplexes in methanogens. Science Advances 12 (38), eaed3711 (2026)

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Zabelskii, D.; Bukhdruker, S.; Lamm, G. H. U.; Bukhalovich, S.; Aoyama, M.; Sudarev, V.; Kuzmin, A.; Shibata, M.; Kotayama, K.; Kandori, H. et al.; Wachtveitl, J.; Bamberg, E.; Gordeliy, V.: Molecular mechanism of calcium inhibition in viral channelrhodopsins. Nature Communications 17, 9875 (2026)

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Duan, Y.; Lu, Y.; Paul, S.; Betz, J.; Wilhelm, L. P.; Cook, A. S. I.; Ren, X.; Adriaenssens, E.; Martens, S.; Ganley, I. G. et al.; Hummer, G.; Hurley, J. H.: Reconstitution of multistep recruitment of ULK1 to membranes in autophagy. Science Advances 12 (36), eaeg3201 (2026)

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Cheng, Y.-L.; Mello-Vieira, J.; Covarrubias-Pinto, A.; Gonzalez, A.; Kumar Kuncha, S.; Kew, C.; Zhang, K.; Awais Afzal, M.; Diab, N.; Borchert, S. et al.; Hong, S.-Y.; Huang, T. C.; Chen, W.; Mato, U. G.; Hornef, M. W.; Hübner, C. A.; Hensel, M.; Dikic, I.: Intracellular lipopolysaccharide binds RETREG1/FAM134B to regulate ER remodeling upon bacterial infection. Autophagy 22 (9), S. 2101 - 2118 (2026)

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Poch, D.; Mukherjee, C.; Mallik, S.; Todorow, V.; Kuiper, E.F. E.; Dhingra, N.; Surovtseva, Y. V.; Schlieker, C.: Integrative chemical genetics platform identifies condensate modulators linked to neurological disorders. Molecular Biology of the Cell 37 (9), ar86 (2026)

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Xavier, A.; Kolling, M.; Bourke, A. M.; Mosler, T.; Prieto-Garcia, C.; Karaulanov, E.; Reissland, M.; Tassetto, M.; Kim, D.; Klaassen, K. et al.; Grikscheit, K.; Torbica, E.; Dederer, V.; Busam, J.; Kazi, R.; Olmer, R.; Pallerla, S. R.; Mathea, S.; Diefenbacher, M. E.; Zarnack, K.; Bojkova, D.; Widera, M.; Aviner, R.; Andino, R.; Ciesek, S.; Dikic, I.: Programmed ribosomal frameshifting triggers translational stress to promote viral replication. Cell 189 (2026)

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Wedel, S.; Claveras Cabezudo, A.; Rauh, O.; Olkhova, E.; Müller, C.; Hahnefeld, L.; Gurke, R.; Geisslinger, G.; Hummer, G.; Sisignano, M.: Lysophospholipid-TRPV1 interactions in chemotherapy-induced neuropathy. Proceedings of the National Academy of Sciences of the United States of America 123 (35), e2613615123 (2026)

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Tuijtel, M. W.; Majtner, T.; Turoňová, B.; Beck, M.: Optimising the tilt increment for in situ cryo-electron tomography. eLife 15, RP111639 (2026)

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Sacco, F.; Baroni, F.; Capolupo, A.; Petrocchi, S.; Zöller, J.; Cerofolini, L.; Russomanno, P.; Calamandrei, R.; Susini, B.; Lin, S. et al.; D'Amici, F.; Ravera, E.; Langer, J. D.; Fragai, M.: Characterization of Full-Length Antibody Complexes Through HDX-Mass Spectrometry Coupled With NMR Spectroscopy: New Insight Into Avelumab/PD-L1 Interaction. Angewandte Chemie International Edition, e1540355 (2026)

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Küffner, A. M.; Pommerenke, B.; Kley, L.; Ng, J. Z. Y.; Prinz, S.; Tinzl-Zechner, M.; Schulz, L.; Claus, P.; Paczia, N.; Chotel, T. et al.; Klose, M.; Zarzycki, J.; Hochberg, G. K. A.; Erb, T. J.: Bottom-up reconstruction of synthetic pyrenoids provides insights into the mechanisms and evolution of carbon concentration by EPYC1 proteins. Nature Plants 12, S. 1622 - 1636 (2026)

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Adélaïde, M.; Yarava, J. R.; Lindemann, F.; Abbas, M.; Cremer, N.; Gerland, L.; Hiller, M.; van Rossum, B.; Linke, D.; Barnes, A. B. et al.; Saliba, E. P.; Yildiz, Ö.; Kühlbrandt, W.; Oschkinat, H.: Structure and Dynamics of Porin Loops in Asymmetric Outer Membranes of E. coli. Chemistry - A European Journal, e71575 (2026)

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Aufdermauer, J.; de Ridder, I.; Ehsani, M.; Khan, M.; Kale, J.; Frenzel, L. P.; Andrews, D.; Karamanou, S.; Garcia Saez, A. J.; Bultynck, G.: Cancer-Associated BCL-2 Mutants Reveal Mechanisms Towards Venetoclax Resistance. Advanced Science, e76693 (2026)

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Tyagi, M.; de Hoog, E.; Grega, M.; Sullivan, K. R.; Walker, A. C.; Chadha, R.; Northrop, A.; Fábián, B.; Hummer, G.; Fuxreiter, M. et al.; Hyman, B. T.; Shepherd, J. D.: Arc mediates intercellular tau transmission via extracellular vesicles. Cell 189 (15), S. 4706 - 4723.e13 (2026)

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Despic, V.; Klostermann, M.; Orekhova, A.; Mesitov, M.; Busch, A.; Zarnack, K.; König, J.; Müller-McNicoll, M.: Isotope-free mapping of protein-RNA interactions at single-nucleotide resolution by iCLIP3. STAR Protocols 7 (3), 104704 (2026)

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Kappelhoff, S.; Holtmannspötter, M.; Schaefer, S. L.; Margheritis, E. G.; Asik, Ö. D.; Gehle, N.; Veit, H.; Danial, J. S. H.; Franzkoch, R.; Strauss, S. et al.; Alvelid, J.; Koerfer, A.; Eggeling, C.; Psathaki, O. E.; Jungmann, R.; Kurre, R.; Hummer, G.; Piehler, J.; Cosentino, K.: Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis. Science Advances 12 (28), eaee4587 (2026)

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Buffa, M.; Leiva, D.; Garcia-Jareño, A.; Garcés-Flores, M.; Díaz, E.; Lucantoni, F.; Telechea, M.; Chen, L.; Lucendo, E.; Shalaby, R. et al.; Lolicato, F.; Kulig, W.; Garcia Saez, A. J.; Moreno-Bueno, G.; Sancho, M.; Orzáez, M.: Disruption of MCL1/BOK transmembrane interaction as a novel strategy to induce cell death in tumours. Cell Death and Disease 17, 824 (2026)

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Kreysing, J. P.; Cruz-León, S.; Betz, J.; Penzo, C.; Majtner, T.; Schreiber, M.; Turoňová, B.; Lusic, M.; Hummer, G.; Beck, M.: Molecular architecture of heterochromatin at the nuclear periphery of primary human cells. Nature Communications 17, 5844 (2026)

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Coshic, K.; Hummer, G.: Extrapolating molecular dynamics simulations to zero time step and across thermodynamic space. The Journal of Chemical Physics 165 (1), 014106 (2026)

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Ehr, J. v.; Schlundt, A.: ¹H, ¹³C, ¹⁵N backbone chemical shift assignments and relaxation analysis of the single and tandem RRMs of the human serine-arginine rich splicing factor 6 (SRSF6). Journal of Magnetic Resonance 388, 108079 (2026)

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Harris, S. A.; Lattanzi, G.; Rosa, A.; Everaers, R.; Papoian, G.; Vidal, A.; Brown, C.; Liverpool, T.; Pasos-Trejo, A.; Sadeghi, M. et al.; Khalid, S.; Ramanathan, A.; Henrich, O.; Dougan, L.; Freyberg, Z.; Pezeshkian, W.; Sept, D.; Geiger, B.; Beccaria, R.; Beales, P.; Covino, R.; Cocking, R.; Castelli, M.; Kundu, S.; Aureli, S.; Breoni, D.; Mazza, F.; Paternoster, C.; Morand, J.; Micheloni, M.; Cordoni, F.; Beaules, L.; van der Hoek, P.; Sillano, P.; Coronas, L. E.; Coshic, K.; Petrolli, L.; Trovato, A.; Karttunen, M.; Bartocci, A.; Inverardi, G. N.; Carnovale, F.: Meso-Soup: A community approach to building a computational description of the biological mesoscale. Biophysical Journal 125 (2026)

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Zeitschriftenartikel

Kraus, F.; He, Y.; Jiang, Y.; Li, D.; Ambaw, Y. A.; Gasparoli, F. M.; Paulo, J. A.; Walther, T. C.; Farese, R. V.; Gygi, S. P. et al.; Wilfling, F.; Harper, J. W.: A human lysosomal storage disorder toolkit for decoding proteome landscapes in cortical-like and dopaminergic-like induced neurons. Proceedings of the National Academy of Sciences of the United States of America 123 (27), e2609132123 (2026)

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Zeitschriftenartikel

Lam, F.; Warwick, T.; Oo, J. A.; Krüger, A. Y.; Kreis, N.-N.; Diagel, A.; Ponce, J. I.; Tirunagari, P.; Bayer, M. E.; Nonn, O. et al.; Dechend, R.; Walther, T.; Boon, R. A.; Baker, A. H.; Günther, S.; Wittig, I.; Chen, Z.; Müller-McNicoll, M.; Louwen, F.; Brandes, R. P.; Leisegang, M. S.: LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing. Molecular Therapy 34 (7), S. 4323 - 4338 (2026)

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Subramaniam, S.; Kühlbrandt, W.; Henderson, R.: Cryo-EM: the revolution continues. IUCrJ 13 (4), S. 306 - 311 (2026)

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Zeitschriftenartikel

Zollo, C.; Gomez Suarez, D.; Bararpour, E. P.; Jenner, A.; Verma, P.; Koch, J.; Wilhelm, S.; Jüngst, C.; Faber, L.; White, F. et al.; García-Sáez, A. J.: DRP1 and MID49 co-diffusion scans mitochondria for fission. Nature Cell Biology 28 (7), S. 1393 - 1407 (2026)

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Zeitschriftenartikel

Weng, T.-H.; Fábián, B.; Olkhova, E.; Welsch, S.; Schmidt, S. L.; Danieli, T.; Keren, Y.; Rimon, A.; Safarian, S.; Hummer, G. et al.; Padan, E.; Michel, H.: pH-dependent activation of the Na⁺/H⁺ antiporter NhaA and conformational dynamics of its N-terminus. Nature Communications 17, 7489 (2026)

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Zeitschriftenartikel

Park, E. C.; Thompson, A. P.; Murphy, J. M.; Liang, L.-Y.; Lucet, I. S.: The multifaceted roles of receptor tyrosine pseudokinases in cellular signalling. Biochemical Society Transactions 54 (6), S. 727 - 743 (2026)

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Zeitschriftenartikel

Vraggalas, S.; Rosenkranz, R. R. E.; Keller, M.; Pérez-Pérez, Y.; Bachiri, S.; Zehl, K. J.; Bold, J.; Simm, S.; Ghatak, A.; Weckwerth, W. et al.; Afjehi-Sadat, L.; Chaturvedi, P.; Testillano, P. S.; Müller-McNicoll, M.; Zarnack, K.; Fragkostefanakis, S.: Splicing regulation by RS2Z36 controls ovary patterning and fruit growth in tomato. Plant Molecular Biology 116, 65 (2026)

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Zeitschriftenartikel

Anastasia, C. M.; Paul, S.; Kim, H.-I.; Cui, Q.; Fairbrother, D. H.; Giraldo, J. P.: Size and Cross-Linking Dependent Gold Nanoparticle Interactions with Dynamic Pectin Model Plant Cell Walls. ACS Nano 20 (21), S. 14980 - 14997 (2026)

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Zeitschriftenartikel

Schreiber, M.; Turoňová, B.: Context matters: A view on metadata analysis in cryo-electron tomography. Current Opinion in Structural Biology 98, 103291 (2026)

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Zeitschriftenartikel

Gestal-Mato, U.; Lascaux, P.; Poveda-Cuevas, S. A.; Cristiani, A.; Camp, B.; Aghapour, M.; Ammanath, A. V.; Bhaskara, R. M.; Dikic, I.; Herhaus, L.: TBK1 restricts IRGQ-mediated autophagy. Nature Communications 17, 4335 (2026)

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Lapenta, F.; Palacio Rodríguez, K.; Cruz-León, S.; Marrancone, S.; Aupič, J.; Marechal, N.; Durand, A.; Moussaoui, D.; Covaceuszach, S.; Gangupam, B. et al.; D'Ercole, C.; Parra, C.; Cotugno, D.; Tomaino, G.; Tortora, P.; de Marco, A.; Cassetta, A.; Magistrato, A.; Hummer, G.: Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations. Nature Communications 17, 6033 (2026)

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Zeitschriftenartikel

Azeez, K. R. A.; Saraswati, H.; Mosler, T.; Hanke, T.; Ho-Xuan, H.; Neder, N.; Sivashanmugam, S. A.; Heinz, M.; Schwalm, M.-P.; Giuliani, G. et al.; Rathore, R.; Kazi, R.; Kumar, R.; Mitrovic, M.; Prieto-Garcia, C.; Bailey, H. J.; Mathea, S.; Hummer, G.; Đikić, I.; Müller, S.; Stolz, A.; Krause, D. S.; Knapp, S.: Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader. ACS Chemical Biology 21 (5), S. 1158 - 1176 (2026)

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Flores-Romero, H.; Pena-Blanco, A.; Aufdermauer, J.; Dadsena, S.; Neubert, P.; Hohorst, L.; Cors, E.; Zollo, C.; Larrañaga-SanMiguel, A.; Zaldunbide, J. et al.; Nenchova, M.; Carvalho-Schaefer, Y.; Langer, T.; Häcker, G.; Garcia Saez, A. J.: MTCH2 promotes BAX and BAK self-assembly and apoptotic pore growth. Nature Structural & Molecular Biology 33 (5), S. 824 - 837 (2026)

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Mello-Vieira, J.; Dikic, I.: Ubiquitination and autophagy in host-pathogen interactions: from immune surveillance to therapeutic targeting. Nature Reviews Immunology 26 (5), S. 335 - 349 (2026)

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Zeitschriftenartikel

Münick, P.; Balourdas, D.-I.; Funk, J. S.; Yüksel, B.; Mavridi, D.; Heftel, J.; Dreier, B.; Schaefer, J. V.; Schäfer, B.; Knapp, S. et al.; Telatar, T.; Akgül, B.; Plückthun, A.; Stiewe, T.; Joerger, A. C.; Dötsch, V.: DARPins as pan-reactivators of temperature-sensitive p53 cancer mutants. Proceedings of the National Academy of Sciences of the United States of America 123 (18), e2531747123 (2026)

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Vlasova, A.; Bukhalovich, S.; Kravtsunova, D.; Gromova, A.; Bagaeva, D.; Zhilinskaya, A.; Bogorodskiy, A.; Ilyinsky, N.; Vlasov, A.; Kuklin, A. et al.; Bamberg, E.; Gordeliy, V.: Cytosol alkalization induces cytosolic and mitochondrial calcium elevation in human cells. Biochemical and Biophysical Research Communications 814, 153551 (2026)

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Kaminer, A.; Li, Y.; Barth, H.-D.; Dietz, M. S.; Heilemann, M.: Quantitative Mapping of Nanoscale EGFR-Grb2 Assemblies by DNA-PAINT. ChemPhysChem 27 (8), e202500915 (2026)

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Zeitschriftenartikel

Geißler, K.; Kreysing, J. P.; Wang, Y.; Glushkova, D.; Obarska-Kosinska, A.; Hoffmann, P. C.; Böhm, S.; Schmidt, A.; Meier-Credo, J.; Langer, J. D. et al.; Hummer, G.; Beck, M.: The vault associates with membranes in situ. Nature Communications 17, 3659 (2026)

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Zeitschriftenartikel

Seifert, M.; Kollenkirchen, T.; Ernst, A.; Rasoulinejad, S.; Koellner, S. M. S.; Schneider, A.-K.; Luzarowski, M.; Lübbehusen, N.; Wu, D.; Kannt, A. et al.; Safarian, S.: Glycan-based biological degraders targeting the cytokine immune axis. Communications Biology 9, 530 (2026)

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Brenner, J.; Plitzko, J. M.; Klumpe, S.: Exploring shaped focused ion beams for lamella preparation. Ultramicroscopy 282, 114302 (2026)

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Bulankina, A. V.; Richter, R. M.; Nettles, J. H.; Yamane, D.; Grimm, C.; Karami, Y.; Stanton, R. A.; Introini, B.; Hermann, J.; Charif, H. et al.; König, M. S.; Stroß, C.; Ortiz, C.; Kraus, N.; Wood, D.; Galceran, F.; Abele, R.; Maigret, B.; Schinazi, R. F.; Zeuzem, S.; Biondi, R. M.; Yi, M.; Tampé, R.; Kudryashev, M.; Welsch, C.: Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling. Science Advances 12 (14), eaeb8863 (2026)

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Zeitschriftenartikel

Nagasse, H. Y.; Okuda, E. K.; Coltri, P. P.: TDP43 and hnRNP K Regulate Alternative Splicing of DNAJC5. Cell Biology International 50 (4), e70158 (2026)

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Shin, J.; Baek, D.; Kim, J.; Park, J.; Jeong, E.; Kim, Y.; Kim, Y. J.; Cho, Y.: Structure of the melatonin-related orphan receptor, GPR50. Molecules and Cells 49 (4), 100331 (2026)

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Neuhaus, A.; McLaren, M.; Isupov, M. N.; Gaines, M.; Buzzard, E.; Sikora, M.; Hanus, C.; Daum, B.; Averhoff, B.; Gold, V. A. M.: Structural insights into the Thermus thermophilus type IV pilus machinery assembling two distinct pili. Communications Biology 9, 474 (2026)

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Seidl, S.; Patra, A. P.; Li, C.; Becker-Baldus, J.; Kaiser, S.; Reinhart, C.; Glaubitz, C.: Detection of an Antagonist Bound to the Neurokinin a Receptor in Styrene-Maleic Acid Lipid Particles by ¹⁹F Ultrafast Magic-Angle Spinning Nuclear Magnetic Resonance Spectroscopy. ChemBioChem: A European Journal of Chemical Biology 27 (6), e202500963 (2026)

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Ibrahim, M.; Köfinger, J.; Zacharias, M.; Schneck, E.; Schwierz, N.: RNA at Lipid/Water Interfaces: Molecular Insights from Coarse-Grained Simulations and Reflectivity Data Predictions. Langmuir 42 (12), S. 8443 - 8452 (2026)

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Kessler, L. F.; Berrevoets, E. S.; Balakrishnan, A.; Okuda, E. K.; Müller-McNicoll, M.; Rieger, B.; Stallinga, S.; Heilemann, M.: Structural cell biology with smart STED microscopy. Conference on Single Molecule Spectroscopy and Superresolution Imaging XIX; San Francisco: JAN 17-19, 2026 (2026)

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Gande, S. L.; Sreeramulu, S.; Saxena, K.; Rupprecht, F. A.; Langer, J. D.; Heumann, H.; Schwalbe, H.: Cupriavidus necator, an alternative source for isotopic enrichment of proteins expressed in insect cells for NMR investigations. Journal of Biomolecular NMR 80, 9 (2026)

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Croce, C. M.; Tait, S. W. G.; García-Sáez, A. J.; Villunger, A.; Letai, A.; Walter, H. S.; Dyer, M. J. S.; Green, D. R.; Shi, Y.; Melino, G.: What does BCL-2 do? From new molecular insights to the clinical implications. Cell Death & Differentiation 33 (4), S. 673 - 693 (2026)

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Schwarz, A.; Mueller, M.; Will, H.; Dietrich, L.; Giandomenico, S. L.; Tushev, G.; Bartnik, I.; Khusainov, I.; Fusco, C. M.; Schuman, E. M.: Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes. Science 391 (6787), eadr4287 (2026)

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Tang, X.; Qu, L.; Wilfling, F.; Beck, F.; Ernst, O. P.; Schulman, B. A.; Baumeister, W.; Enenkel, C.: Metabolically regulated proteasome supramolecular organization in situ. Cell 189 (4), S. 1153 - 1169.e16 (2026)

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Franco, P. H. C.; Üresin, D.; Borst, A.; Rusling, L. A.; Soppa, J.; Langer, J. D.: Proteome characterization of single gene deletion mutants lacking zinc finger µ-proteins in Haloferax volcanii. microLife 7, uqag005 (2026)

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Debnath, J.; Hummer, G.: Random Functions as Data Compressors for Machine Learning of Molecular Processes. Journal of Chemical Theory and Computation 22 (3), S. 1504 - 1513 (2026)

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Schreiber, M.; Turoňová, B.: TANGO: Analysis and curation of particles in cryo-electron tomography. Nature Communications 17, 1557 (2026)

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Storm, K. R.; Wiebeler, C.; Cruz-León, S.; Körösy, C.; Schwierz, N.; Lipfert, J.: DNA twist at high alkali ion concentrations: evidence against C-form DNA in solution. Nucleic Acids Research 54 (5), gkag192 (2026)

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Tesmer, L.; Matter, H.; Klingler, O.; Schudok, M.; Hessler, G.; Mehdipour, A. R.; Güssregen, S.; Schreuder, H.; Hummer, G.: Nonstandard Factor VIIa Binding Mode Reveals S1 Pocket Plasticity in Trypsin-Like Proteases. ChemMedChem 21 (2), e202500846 (2026)

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Martínez-Osorio, V.; Ros, U.; García-Sáez, A. J.: Spotted: RIPK3 and MLKL assembling necroptotic complexes. Open Biology 16 (1), 250236 (2026)

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Schäfer, D.; Prieto-Garcia, C.; Wang, J.; Heinz, M.; Matkovic, V.; Kielkowski, P.; Hasselbeck, S.; Shah, V. J.; Knapp, S.; Hummer, G. et al.; Dikic, I.; Cheng, X.: Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation. Angewandte Chemie (International Ed. in English) 65 (5), e16809 (2026)

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Kompa, J.; Dornfeld, L. J.; Porzberg, N.; Jang, S.; Zedlitz, S.; Lilje, S. H.; Catapano, C.; Jocher, D.; Merk, L.; Hoege, C. et al.; Mao, R.; Wilhelm, J.; Dietz, M. S.; Tarnawski, M.; Hiblot, J.; Hyman, A. A.; Heilemann, M.; Johnsson, K.: Fast, Bright, and Reversible Fluorescent Labeling of Rhodamine-Binding Proteins. Journal of the American Chemical Society 148 (1), S. 1419 - 1429 (2026)

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Babic, R.; Brenneisen, J.; Wilfling, F.; Kraft, C.: Autophagy regulation by phase separation, avidity, and wetting. Trends in Biochemical Sciences 51 (1), S. 27 - 38 (2026)

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Glushkova, D.; Böhm, S.; Beck, M.: Systematic membrane thickness variation across cellular organelles revealed by cryo-ET. Journal of Cell Biology 225 (1), e202504053 (2026)

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Paul, S.: Integrative Multiscale Simulations Uncover the Mechanistic Principles Governing COPII Mediated Vesicle Formation. The Journal of Membrane Biology 259 (1), 1 (2026)

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Post, M.; Hummer, G.: AI-guided transition path sampling of lipid flip-flop and membrane nanoporation. Nature Communications 17, 224 (2026)

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2025

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Dutta, A.; Cristiani, A.; Nikte, S. V.; Eisert, J.; Matthess, Y.; Markusic, B.; Tudose, C.; Becht, C.; Cetin, R.; Shah, V. J. et al.; Mosler, T.; Husnjak, K.; Dikic, I.; Kaulich, M.; Bhaskara, R. M.: Multi-scale classification decodes the complexity of the human E3 ligome. Nature Communications 16, 11382 (2025)

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Natriashvili, A.; Mohammadsadeghi, N.; Milanov, M.; Smudde, E.; Prucker, I.; Jessen, H. J.; Carabadjac, I.; Heerklotz, H.; Franco, P. H. C.; Langer, J. D. et al.; Koch, H.-G.: Metabolic silencing induced by the small bacterial membrane protein YohP. iScience 28 (12), 114123 (2025)

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Mineev, K. S.; Gande, S. L.; Wenzel, A.; Linhard, V.; Andrews-Clark, H.; Witt, K.; Köster, S.; Segarra, M.; McDowell, M. A.; Acker-Palmer, A. et al.; Schwalbe, H.: Structural Role of Conformational Heterogeneity and Juxtamembrane Regions in the Ephrin A1 Interactions With the EphA2 Receptor Ligand-binding Domain. Journal of Molecular Biology 437 (24), 169454 (2025)

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Roos, L.; Garrido-Charles, A.; Albrecht, N.; Vavakou, A.; Alekseev, A.; Bleyer, M.; Thirumalai, A.; Mittring, A.; Alvanos, T.; Huet, A. T. et al.; Bamberg, E.; Kusch, K.; Wolf, B. J.; Moser, T.; Mager, T.: Channelrhodopsin variants for high-rate optogenetic neurostimulation at low light intensities. Embo Molecular Medicine 18 (2), S. 462 - 491 (2025)

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Birtasu, A. N.; Wieland, K.; Ermel, U. H.; Arghittu, S. M.; Manger, S.; Kocylowski, M. K.; Fakler, B.; Scheffer, M. P.; Covino, R.; Grahammer, F. et al.; Frangakis, A. S.: The kidney slit diaphragm resembles a fishnet. Kidney International 108 (6), S. 1045 - 1056 (2025)

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Majoul, A.; Garcia-Saez, A. J.: Dynamic regulation of cell death signaling. Current Opinion in Cell Biology 97, 102583 (2025)

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Majtner, T.; Turoňová, B.: Automated removal of corrupted tilts in cryo-electron tomography. Journal of Structural Biology: X 12, 100130 (2025)

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Okuda, E. K.; Kessler, L. F.: A new rapid-degradation system combined with super-resolution microscopy. Nature Reviews Molecular Cell Biology 26 (12), S. 904 (2025)

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Berrevoets, E. S.; Kessler, L. F.; Balakrishnan, A.; Okuda, E. K.; Müller-McNicoll, M.; Rieger, B.; Stallinga, S.; Heilemann, M.: Smart 3D super-resolution microscopy reveals the architecture of the RNA scaffold in a nuclear body. Nature Communications 16, 10689 (2025)

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Hewel, C.; Wierczeiko, A.; Miedema, J.; Friedrich, J.; Hofmann, F.; Weißbach, S.; Dietrich, V.; Holthöfer, L.; Haug, V.; Mündnich, S. et al.; Schartel, L.; Lehmann, L.; Jensen, K. L.; Diederich, S.; Sys, S.; Butto, T.; Paul, N. W.; Koch, J.; Lyko, F.; Kraft, F.; Russo, A.; Schweiger, S.; Lemke, E. A.; Helm, M.; Linke, M.; Gerber, S.: Direct RNA sequencing enables improved transcriptome assessment and tracking of RNA modifications for medical applications. Nucleic Acids Research 53 (22), gkaf1314 (2025)

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Müller-McNicoll, M.: Getting sticky: How nuclear speckles tune the condensation-prone proteome. Molecular Cell 85 (22), S. 4116 - 4118 (2025)

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Germain, H.; Hoffmann, P. C.: The Arabidopsis thaliana nuclear pore complex structure reveals conserved and distinct features. Nature Plants 11, S. 2198 - 2199 (2025)

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Rosenkranz, N.; Birtasu, A. N.; Wieland, K.; Rehm, L.; Sharma, R.; Vats, A.; Manger, S.; Srivastava, A.; Bhattacharya, A.; Hummer, G. et al.; Frangakis, A. S.; Gottschalk, A.: In situ structure of a gap junction-stomatin complex. Science Advances 11 (45), eaea8596 (2025)

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Mondal, S.; Mukherjee, S.; Namitz, K. E. W.; Yennawar, N. H.; Boehr, D. D.: Multivalent Interactions Between the Picornavirus 3C(D) Main Protease and RNA Oligonucleotides Induce Liquid-Liquid Phase Separation. Viruses 17 (11), 1473 (2025)

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Hohorst, L.; Ros, U.; Garcia-Saez, A. J.: Mitochondrial dynamics and pore formation in regulated cell death pathways. Trends in Biochemical Sciences 50 (11), S. 1001 - 1014 (2025)

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Sanchez Carrillo, I. B.; Hoffmann, P. C.; Obarska-Kosinska, A.; Fourcassié, V.; Beck, M.; Germain, H.: In situ architecture of the nuclear pore complex of the higher plant Arabidopsis thaliana. Nature Plants 11, S. 2368 - 2380 (2025)

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Yang, T.-J.; Mukherjee, S.; Langer, J. D.; Hummer, G.; McDowell, M. A.: SND3 is the membrane insertase within a distinct SEC61 translocon complex. Nature Communications 16, 9566 (2025)

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Lago-Maciel, A.; Soares, J. C.; Zarzycki, J.; Buchanan, C. J.; Reif-Trauttmansdorff, T.; Schmidt, F. V.; Lometto, S.; Paczia, N.; Schuller, J. M.; Hansen, D. F. et al.; Heller, G. T.; Prinz, S.; Hochberg, G. K. A.; Pierik, A. J.; Rebelein, J. G.: Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage. Nature Catalysis 8 (10), S. 1086 - 1099 (2025)

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Bresciani, V.; Rinaldi, F.; Franco, P.; Girotto, S.; Cavalli, A.; Langer, J. D.; Masetti, M.; Bernetti, M.: Dissecting the RAD51–BRC4 Interaction Landscape through Integrative Molecular Simulations and Experimental Biophysics. Journal of Chemical Information and Modeling 65 (21), S. 11965 - 11978 (2025)

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Grabarczyk, D. B.; Aird, E. J.; Reznikow, V.; Kirchgatterer, P. C.; Ehrmann, J. F.; Kurzbauer, R.; Bell, L. E.; Kellner, M. J.; Aggarwal, R.; Schleiffer, A. et al.; Faas, V.; Deszcz, L.; Meinhart, A.; Versteeg, G. A.; Penninger, J. M.; Stelzl, L. S.; Gaidt, M. M.; Tessmer, I.; Corn, J. E.; Clausen, T.: A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles. Cell 188 (21), S. 5995 - 6011 (2025)

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Sachweh, J.; Börmel, M.; Klumpe, S.; Becker, A.; Taniguchi, R.; Kubańska, M. A.; Pintschovius, V.; Kaindl, E.; Plitzko, J. M.; Wilfling, F. et al.; Beck, M.; Hampoelz, B.: The small GTPase Ran defines nuclear pore complex asymmetry. Cell 188 (21), S. 5931 - 5946 (2025)

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Langschied, F.; Iruegas, R.; Sikora, M.; Covino, R.; Ebersberger, I.: A Multi-level Perspective on the Evolution of Orthologs and Their Functions. Journal of Molecular Evolution 93, S. 720 - 729 (2025)

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Grothaus, I. L.; Spellerberg, P.; Rovira, C.; Colombi Ciacchi, L.: Shaping the Glycan Landscape: Hidden Relationships between Linkage and Ring Distortions Induced by Carbohydrate-Active Enzymes. Journal of the American Chemical Society 147 (42), S. 38376 - 38389 (2025)

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Majtner, T.; Kreysing, J. P.; Tuijtel, M.; Cruz-León, S.; Liu, J.; Hummer, G.; Beck, M.; Turoňová, B.: cryoTIGER: deep-learning based tilt interpolation generator for enhanced reconstruction in cryo electron tomography. Communications Biology 8, 1443 (2025)

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Kumari, R.; Nath, T.; Pflaum, J.; R, I.; Vinay, S.; Wilfling, F.; Manjithaya, R.: The autophagy-specific exocyst subcomplex contributes to phagophore assembly site integrity by promoting phagophore expansion. Proceedings of the National Academy of Sciences of the United States of America 122 (41), e2426476122 (2025)

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Hasselbeck, S.; Wang, J.; Bai, Z.; Hüfner, T.; Hummer, G.; Grote, P.; Cheng, X.: A Chemically Induced CRISPR/dCas13^FCPF Platform for Precise and Programmable RNA Regulation. Journal of Medicinal Chemistry 68, S. 22633 - 22649 (2025)

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Manger, S.; Arghittu, S. M.; Sprankel, L.; Meier-Credo, J.; Wieland, K.; Bublak, D.; Langer, J. D.; Covino, R.; Frangakis, A. S.: How does Mycoplasma pneumoniae scavenge lipids from its host membranes? Science Advances 11 (40), eady4746 (2025)

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Zaghbani, S.; Faber, L.; Garcia Saez, A. J.: Convolutional Neural Network approach to classify mitochondrial morphologies. Computational Biology and Chemistry 118, 108477 (2025)

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Ho-Xuan, H.; Bruckmann, A.; Natali, L.; Prieto-Garcia, C.; Stuke, J. F. M.; Brunello, L.; Vicente, A.; Pfab, A.; Wesseling, H.; Cano-Franco, S. et al.; Khatri, A.; Larivera, S.; Sanz-Martinez, P.; de la Cruz-Thea, B.; Jacomin, A.-C.; Prochazka, J.; Feederle, R.; Dötsch, V.; Sedlacek, R.; Hummer, G.; Kaiser, S.; Dikic, I.; Musri, M. M.; Meister, G.; Stolz, A.: YTHDF proteins and m⁶A-RNA clients undergo autophagic turnover during contact inhibition. Cell Reports 44 (9), 116188 (2025)

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Fábián, B.; Stuke, J. F. M.; Heinz, M.; Hummer, G.: AlphaFold modeling of polyubiquitin complexes and covalently linked proteins. Cell Reports Physical Science 6 (9), 102796 (2025)

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Sucharitakul, J.; Mangkalee, M.; Intasian, P.; Pornsuwan, S.; Ermler, U.; Buckel, W.; Chaiyen, P.: Kinetic mechanisms of electron bifurcation with electron transfer flavoprotein, NADH, butyryl-CoA dehydrogenase, and ferredoxin reveal a semiquinone cycle. Journal of Biological Chemistry 301 (10), 110727 (2025)

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King, L. E.; Faber, L.; García-Sáez, A. J.: Activator of apoptosis harakiri (HRK) localisation at mitochondria alters mitochondrial morphology independently of other BCL-2 proteins. The FEBS Journal 292 (2), S. 549 - 564 (2025)

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Brdar, A.; Osterburg, C.; Münick, P.; Machel, A. C.; Rathore, R.; Osterburg, S.; Yüksel, B.; Schäfer, B.; Desch, K.; Langer, J. D. et al.; Dikic, I.; Dötsch, V.: p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners. eLife 13, RP103537 (2025)

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Shrestha, R.; Alessandri, R.; Vögele, M.; Hilpert, C.; Souza, P. C. T.; Marrink, S. J.; Monticelli, L.: Martini 3 Coarse-Grained Models for Carbon Nanomaterials. Journal of Chemical Theory and Computation 21 (18), S. 9035 - 9053 (2025)

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Zietek, M.; Miguel, A.; Shi, H.; Khusainov, I.; Asmar, A. T.; Ram, S.; Wartel, M.; Sueki, A.; Schorb, M.; Goulian, M. et al.; Collet, J.-F.; Beck, M.; Huang, K. C.; Typas, A.: Bacterial cell widening alters periplasmic size and activates envelope stress responses. The EMBO Journal 44 (20), S. 5816 - 5833 (2025)

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Blum, T. B.; Davies, K. M.; Kühlbrandt, W.: Subtomogram averages of mitochondrial ATP synthase dimers from plants show a conserved extra density at the peripheral stalk. IUCrJ 12, S. 563 - 569 (2025)

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