Structure and Molecular Mechanism of the Sodium-Proton-Antiporter NhaA and the Cytochrome-bc1-Complex

Research report (imported) 2007 - Max Planck Institute of Biophysics

Hunte, Carola
Molekulare Membranbiologie (Prof. Dr. Dr. h.c. Hartmut Michel)
MPI für Biophysik, Frankfurt am Main
1. Variants of the mitochondrial cytochrome bc1 complex created by site-directed mutagenesis produce deleterious oxygen radicals, which are implied in aging processes and pathophysiological conditions. 2. The regulation of the cellular ion composition by sodium-proton-antiporters is essential. The first atomic structure of such a transporter was determined and a mechanistic model for regulation and transport developed.

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