Welcome to the Max Planck Institute of Biophysics!

The Max Planck Institute of Biophysics focuses on investigating the structure and function of proteins that are embedded in cellular membranes. Membrane proteins functioning as channels, transporters, or molecular sensors mediate the exchange of matter and information of cells with their environment.

Looking for a PhD student position in the life sciences? Apply for the IMPRS on Cellular Biophysics!

The International Max Planck Research School on Cellular Biophysics (IMPRS-CBP) is an international doctoral training program hosted by the Max Planck Institute of Biophysics, the Goethe University Frankfurt, the Johannes Gutenberg University Mainz, and the Frankfurt Institute of Advanced Studies. The IMPRS-CBP invites excellent graduate students in life sciences to apply for fully funded PhD student positions.

New discovery of researchers from the MPI of Biophysics in Science magazine: nuclear pore complexes are mechanosensitive

Channels within the nuclear membrane of eukaryotic cells, the so-called nuclear pore complexes, enable the exchange of material between nucleus and cystosol. A group of scientists led by Martin Beck has, in collaboration with the groups of Gerhard Hummer (MPIBP), Julia Mahamid (EMBL) and Jan Kosinski (EMBL), published new insights into the dynamics of the 3D structure of such channels in the scientific journal Science. By showing that membrane tension influences the diameter of the nuclear pore complexes, they identified an unexpected way of regulating the transport in and out of the nucleus under different physiological conditions such as cellular stress. (Visuals: Antoni Kosinski)
 

Werner Kühlbrandt receives the Cothenius Medal for his lifetime achievement

With this award, the German National Academy of Sciences Leopoldina honours Werner Kühlbrandt, Director of the Department of Structural Biology, for his outstanding scientific lifetime achievement.

Murphy group’s work published in Science magazine: How methanogenic microbes manage electrons

This month, the renowned Science magazine published new results from Olivia Pfeil-Gardiner and Bonnie Murphy (Max Planck Insitut of Biophysics) in collaboration with researchers from the Max Planck Insitute for Terrestrial Microbiology, Marburg. New structures solved by the group shed light on direct and conformationally-controlled electron transfer for CO2 fixation in methanogens.

Coming February 2022: New research group of Melanie McDowell

We are proud to announce that Melanie McDowell has been awarded a Max Planck Research Group Leader Position to start at our institute in February 2022. She aims to structurally characterise membrane protein biogenesis pathways at the endoplasmic reticulum. There will be open Postdoc, PhD and Technician positions. Click here for more information.

 
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Our Research 

How do molecular modules act in concert to generate complex cellular functions?
How can we make the most of cryo-electron microscopy for determining the structure and function of membrane protein complexes?

What are the universal principles that underlie chromosome organization across all forms of life?
What molecular mechanisms control the delivery and correct insertion of membrane proteins at the endoplasmic reticulum?
How to generate and use structural information to investigate function and mechanisms of membrane protein complexes.
 
Our software method development focuses on improving tomogram quality and integrating contextual information into subtomogram averaging routines.
Our state-of-the-art equipment, and technical and scientific user support allow for novel insights into biological structures and molecular mechanisms.

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Latest Publications

1.
Journal Article
Maximilian Seidel, Anja Becker, Filipa Pereira, Jonathan J. M. Landry, Nayara Trevisan Doimo de Azevedo, Claudia M. Fusco, Eva Kaindl, Natalie Romanov, Janina Baumbach, Julian David Langer, Erin M. Schuman, Kiran Raosaheb Patil, Gerhard Hummer, Vladimir Benes, and Martin Beck, "Co-translational assembly orchestrates competing biogenesis pathways," Nature Communications 13, 1224 (2022).
2.
Journal Article
Wen-Ting Lo, Yingyi Zhang, Oscar Vadas, Yvette Roske, Federico Gulluni, Maria Chiara De Santis, Andreja Vujicic Zagar, Heike Stephanowitz, Emilio Hirsch, Fan Liu, Oliver Daumke, Misha Kudryashev, and Volker Haucke, "Structural basis of phosphatidylinositol 3-kinase C2α function," Nature Structural and Molecular Biology (2022).

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