Ana J. García-Sáez: Membrane Dynamics – Department Publications

Flores-Romero, H.; Pena-Blanco, A.; Aufdermauer, J.; Dadsena, S.; Neubert, P.; Hohorst, L.; Cors, E.; Zollo, C.; Larrañaga-SanMiguel, A.; Zaldunbide, J. et al.; Nenchova, M.; Carvalho-Schaefer, Y.; Langer, T.; Häcker, G.; Garcia Saez, A. J.: MTCH2 promotes BAX and BAK self-assembly and apoptotic pore growth. Nature Structural & Molecular Biology 33 (5), pp. 824 - 837 (2026)

Croce, C. M.; Tait, S. W. G.; García-Sáez, A. J.; Villunger, A.; Letai, A.; Walter, H. S.; Dyer, M. J. S.; Green, D. R.; Shi, Y.; Melino, G.: What does BCL-2 do? From new molecular insights to the clinical implications. Cell Death & Differentiation 33 (4), pp. 673 - 693 (2026)

Martínez-Osorio, V.; Ros, U.; García-Sáez, A. J.: Spotted: RIPK3 and MLKL assembling necroptotic complexes. Open Biology 16 (1), 250236 (2026)

Majoul, A.; Garcia-Saez, A. J.: Dynamic regulation of cell death signaling. Current Opinion in Cell Biology 97, 102583 (2025)

Hohorst, L.; Ros, U.; Garcia-Saez, A. J.: Mitochondrial dynamics and pore formation in regulated cell death pathways. Trends in Biochemical Sciences 50 (11), pp. 1001 - 1014 (2025)

Zaghbani, S.; Faber, L.; Garcia Saez, A. J.: Convolutional Neural Network approach to classify mitochondrial morphologies. Computational Biology and Chemistry 118, 108477 (2025)

King, L. E.; Faber, L.; García-Sáez, A. J.: Activator of apoptosis harakiri (HRK) localisation at mitochondria alters mitochondrial morphology independently of other BCL-2 proteins. The FEBS Journal 292 (2), pp. 549 - 564 (2025)

Zaghbani, S.; Pranti, R. K.; Faber, L.; Garcia-Saez, A. J.: MitoSkel: AI tool for semantic segmentation and quantification of mitochondria from light microscopy images. Biomedical Signal Processing and Control 106, 107762 (2025)

Perez-Rivera, E.; Plasencia, C.; Ros, U.: The Multifaceted Role of Calcium Signaling in Regulated Necrosis. Biomolecules 15 (6), 854 (2025)

Garcia-Saez, A. J.; McBride, H.: Special Issue – Cell Biology of Mitochondria. Journal of Cell Science 138 (9), jcs264067 (2025)

Ros, U.; Martinez-Osorio, V.; Valiente, P. A.; Abdelwahab, Y.; Gojkovic, M.; Shalaby, R.; Zanna, S.; Saggau, J.; Wachsmuth, L.; Nemade, H. N. et al.; Zoeller, J.; Lottermoser, H.; Chen, Y.-G.; Ibrahim, M.; Kelepouras, K.; Vasilikos, L.; Bedoya, P.; Espiritu, R. A.; Müller, S.; Altmannova, V.; Tieleman, D. P.; Weir, J.; Langer, J. D.; Adam, M.; Walczak, H.; Wong, W. W.-L.; Liccardi, G.; Mollenhauer, M.; Pasparakis, M.; Peltzer, N.; García-Sáez, A. J.: MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Molecular Cell 85 (8), pp. 1589 - 1605 (2025)

Smarduch, S.; Moreno-Velasquez, S. D.; Ilic, D.; Dadsena, S.; Morant, R.; Ciprinidis, A.; Pereira, G.; Binder, M.; García-Sáez, A. J.; Acebrón, S. P.: A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA. The EMBO Journal 44 (7), pp. 2157 - 2182 (2025)

Roeck, B. F.; Lotfipour Nasudivar, S.; Vorndran, M. R. H.; Schueller, L.; Yapici, F. I.; Rübsam, M.; von Karstedt, S.; Niessen, C. M.; Garcia-Saez, A. J.: Ferroptosis spreads to neighboring cells via plasma membrane contacts. Nature Communications 16, 2951 (2025)

Pedrera, L.; Prieto Clemente, L.; Dahlhaus, A.; Lotfipour Nasudivar, S.; Tishina, S.; Olmo González, D.; Stroh, J.; Yapici, F. I.; Singh, R. P.; Grotehans, N. et al.; Langer, T.; García-Sáez, A. J.; von Karstedt, S.: Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death and Disease 16, 40 (2025)

Etxebeste-Mitxeltorena, M.; Flores-Romero, H.; Ramos-Inza, S.; Masiá, E.; Nenchova, M.; Montesinos, J.; Martinez-Gonzalez, L.; Porras, G.; Orzáez, M.; Vicent, M. J. et al.; Gil, C.; Area-Gomez, E.; Garcia-Saez, A. J.; Martinez, A.: Modulation of Mitochondria-Endoplasmic Reticulum Contacts (MERCs) by Small Molecules as a New Strategy for Restoring Lipid Metabolism in an Amyotrophic Lateral Sclerosis Model. Journal of Medicinal Chemistry 68 (2), pp. 1179 - 1194 (2025)

Lotfipour Nasudivar, S.; Pedrera, L.; García-Sáez, A. J.: Iron-Induced Lipid Oxidation Alters Membrane Mechanics Favoring Permeabilization. Langmuir 40 (47), pp. 2561 - 2568 (2024)

Berndt, C.; Alborzinia, H.; Amen, V. S.; Ayton, S.; Barayeu, U.; Bartelt, A.; Bayir, H.; Bebber, C. M.; Birsoy, K.; Böttcher, J. P. et al.; Brabletz, S.; Brabletz, T.; Brown, A. R.; Brüne, B.; Bulli, G.; Bruneau, A.; Chen, Q.; DeNicola, G. M.; Dick, T. P.; Distéfano, A.; Dixon, S. J.; Engler, J. B.; Esser-von Bieren, J.; Fedorova, M.; Friedmann Angeli, J. P.; Friese, M. A.; Fuhrmann, D. C.; García-Sáez, A. J.; Garbowicz, K.; Götz, M.; Gu, W.; Hammerich, L.; Hassannia, B.; Jiang, X.; Jeridi, A.; Kang, Y. P.; Kagan, V. E.; Konrad, D. B.; Kotschi, S.; Lei, P.; Le Tertre, M.; Lev, S.; Liang, D.; Linkermann, A.; Lohr, C.; Lorenz, S.; Luedde, T.; Methner, A.; Michalke, B.; Milton, A. V.; Min, J.; Mishima, E.; Müller, S.; Motohashi, H.; Muckenthaler, M. U.; Murakami, S.; Olzmann, J. A.; Pagnussat, G.; Pan, Z.; Papagiannakopoulos, T.; Pedrera Puentes, L.; Pratt, D. A.; Proneth, B.; Ramsauer, L.; Rodriguez, R.; Saito, Y.; Schmidt, F.; Schmitt, C.; Schulze, A.; Schwab, A.; Schwantes, A.; Soula, M.; Spitzlberger, B.; Stockwell, B. R.; Thewes, L.; Thorn-Seshold, O.; Toyokuni, S.; Tonnus, W.; Trumpp, A.; Vandenabeele, P.; Vanden Berghe, T.; Venkataramani, V.; Vogel, F. C. E.; von Karstedt, S.; Wang, F.; Westermann, F.; Wientjens, C.; Wilhelm, C.; Wölk, M.; Wu, K.; Yang, X.; Yu, F.; Zou, Y.; Conrad, M.: Ferroptosis in health and disease. Redox Biology: an official journal of the Society for Free Radical Biology and Medicine 75, 103211 (2024)

Dadsena, S.; Cuevas Arenas, R.; Vieira, G.; Brodesser, S.; Melo, M. N.; García-Sáez, A. J.: Lipid unsaturation promotes BAX and BAK pore activity during apoptosis. Nature Communications 15, 4700 (2024)

Froehlich, T.; Jenner, A.; Cavarischia-Rega, C.; Fagbadebo, F. O.; Lurz, Y.; Frecot, D. I.; Kaiser, P. D.; Nueske, S.; Scholz, A. M.; Schäffer, E. et al.; Garcia Saez, A. J.; Macek, B.; Rothbauer, U.: Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1. Life science alliance 7 (8), e202402608 (2024)

Dellmann, T.; Shalaby, R.; Garcia-Saez, A. J.: Super-resolution microscopy methods to study membrane pores in situ. In: Methods in Enzymology, Vol. 700, pp. 161 - 187 (Eds. Baumgart, T.; Deserno, M.). Academic Press (2024)