Image of Dr. Marcel Heinz

Dr. Marcel Heinz

Postdoctoral Researcher
Department “Gerhard Hummer: Theoretical Biophysics”

Main Focus

Simulations and design of targeted protein interactions as a new mode of action for drugs

  • Protein-protein interactions
  • PROTACs and Molecular Glues

Simulation of chemically modified nucleic acids

Curriculum Vitae

  • since 2021 Postdoctoral Researcher
    Max Planck Institute of Biophysics, Frankfurt am Main
    Department of Theoretical Biophysics, with Prof. Dr. Gerhard Hummer
  • 2016–2022 Ph.D. in Chemistry
    Max Planck Institute of Biophysics, and Goethe University, Frankfurt am Main
    Department of Theoretical Biophysics, with Prof. Dr. Gerhard Hummer
  • 2013–2015 M.Sc. in Chemistry
    Goethe University, Frankfurt am Main
  • 2009–2013 B.Sc. in Chemistry
    Goethe University, Frankfurt am Main

Marcel Heinz Publications

Journal Article (11)

2025
Journal Article
Schäfer, D.; Prieto-Garcia, C.; Wang, J.; Heinz, M.; Matkovic, V.; Kielkowski, P.; Hasselbeck, S.; Shah, V. J.; Knapp, S.; Hummer, G. et al.; Dikic, I.; Cheng, X.: Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation. Angewandte Chemie (International Ed. in English), p. e16809 (2025)
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Full
Journal Article
Fábián, B.; Stuke, J. F. M.; Heinz, M.; Hummer, G.: AlphaFold modeling of polyubiquitin complexes and covalently linked proteins. Cell Reports Physical Science 6 (9), 102796 (2025)
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2024
Journal Article
Gauger, M.; Heinz, M.; Halbritter, A.-L. J.; Stelzl, L. S.; Erlenbach, N.; Hummer, G.; Sigurdsson, S. T.; Prisner, T.: Structure and internal dynamics of short RNA duplexes determined by a combination of pulsed EPR methods and MD simulations. Angewandte Chemie, International Edition in English 63, e202402498 (2024)
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Journal Article
Wang, J.; Heinz, M.; Han, K.; Shah, V. J.; Hasselbeck, S.; Schwalm, M. P.; Rathore, R.; Hummer, G.; Zhou, J.; Dikic, I. et al.; Cheng, X.: Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN. Cell Reports Physical Science 5 (5), 101960 (2024)
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2023
Journal Article
Ibrahim, M.; Gilbert, J.; Heinz, M.; Nylander, T.; Schwierz, N.: Structural insights on ionizable Dlin-MC3-DMA lipids in DOPC layers by combining accurate atomistic force fields, molecular dynamics simulations and neutron reflectivity. Nanoscale 15 (27), pp. 11647 - 11656 (2023)
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2020
Journal Article
Heinz, M.; Erlenbach, N.; Stelzl, L. S.; Thierolf, G.; Kamble, N. R.; Sigurdsson, S. T. H.; Prisner, T. F.; Hummer, G.: High-resolution EPR distance measurements on RNA and DNA with the non-covalent Ǵ spin label. Nucleic Acids Research 48 (2), pp. 924 - 933 (2020)
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Journal Article
Shin, D.; Mukherjee, R.; Liu, Y.; Gonzalez, A.; Bonn, F.; Liu, Y.; Rogov, V. V.; Heinz, M.; Stolz, A.; Hummer, G. et al.; Dötsch, V.; Luo, Z.-Q.; Bhogaraju, S.; Đikić, I.: Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB. Molecular Cell 77 (1), pp. 164 - 179 (2020)
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2018
Journal Article
Grotz, K. K.; Nueesch, M. F.; Holmstrom, E. D.; Heinz, M.; Stelzl, L. S.; Schuler, B.; Hummer, G.: Dispersion Correction Alleviates Dye Stacking of Single-Stranded DNA and RNA in Simulations of Single-Molecule Fluorescence Experiments. The Journal of Physical Chemistry B 122 (49), pp. 11626 - 11639 (2018)
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Journal Article
Seyfried, P.; Heinz, M.; Pintér, G.; Klötzner, D.-P.; Becker, Y.; Bolte, M.; Jonker, H. R. A.; Stelzl, L. S.; Hummer, G.; Schwalbe, H. et al.; Heckel, A.: Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging. Chemistry – A European Journal 24 (66), pp. 17568 - 17576 (2018)
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2017
Journal Article
Stelzl, L. S.; Erlenbach, N.; Heinz, M.; Prisner, T. F.; Hummer, G.: Resolving the Conformational Dynamics of DNA with Ångstrom Resolution by Pulsed Electron–Electron Double Resonance and Molecular Dynamics. Journal of the American Chemical Society 139 (34), pp. 11674 - 11677 (2017)
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2015
Journal Article
Barends, T. R.M.; Foucar, L.; Ardevol, A.; Nass, K.; Aquila, A.; Botha, S.; Doak, R. B.; Falahati, K.; Hartmann, E.; Hilpert, M. et al.; Heinz, M.; Hoffmann, M. C.; Köfinger, J.; Koglin, J. E.; Kovacsova, G.; Liang, M.; Milathianaki, D.; Lemke, H. T.; Reinstein, J.; Roome, C. M.; Shoeman, R. L.; Williams, G. J.; Burghardt, I.; Hummer, G.; Boutet, S.; Schlichting, I.: Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation. Science 350 (6259), pp. 445 - 450 (2015)
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Thesis - PhD (1)

2021
Thesis - PhD
Heinz, M.: Molecular Simulation and Modeling of Chemically Modified Nucleic Acids. Dissertation, 174 pp., Fachbereich Biochemie, Chemie und Pharmazie, Johann Wolfgang Goethe Universität, Frankfurt am Main (2021)
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Thesis - Master (1)

2015
Thesis - Master
Heinz, M.: Protein Ligand Dynamics in Myoglobin. Master, 66 pp., Institut für Physikalische und Theoretische Chemie, Goethe-Universität Frankfurt, Frankfurt am Main (2015)
MPG.PuRe

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