Dr. Marcel Heinz
Postdoctoral ResearcherDepartment “Gerhard Hummer: Theoretical Biophysics”
Main Focus
Simulations and design of targeted protein interactions as a new mode of action for drugs
- Protein-protein interactions
- PROTACs and Molecular Glues
Simulation of chemically modified nucleic acids
Curriculum Vitae
- since 2021 Postdoctoral Researcher
Max Planck Institute of Biophysics, Frankfurt am Main
Department of Theoretical Biophysics, with Prof. Dr. Gerhard Hummer - 2016–2022 Ph.D. in Chemistry
Max Planck Institute of Biophysics, and Goethe University, Frankfurt am Main
Department of Theoretical Biophysics, with Prof. Dr. Gerhard Hummer - 2013–2015 M.Sc. in Chemistry
Goethe University, Frankfurt am Main - 2009–2013 B.Sc. in Chemistry
Goethe University, Frankfurt am Main
Marcel Heinz Publications
Journal Article (9)
2024
Journal Article
63, e202402498 (2024)
Structure and internal dynamics of short RNA duplexes determined by a combination of pulsed EPR methods and MD simulations. Angewandte Chemie, International Edition in English
Journal Article
5 (5), 101960 (2024)
Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN. Cell Reports Physical Science 2023
Journal Article
15 (27), pp. 11647 - 11656 (2023)
Structural insights on ionizable Dlin-MC3-DMA lipids in DOPC layers by combining accurate atomistic force fields, molecular dynamics simulations and neutron reflectivity. Nanoscale 2020
Journal Article
48 (2), pp. 924 - 933 (2020)
High-resolution EPR distance measurements on RNA and DNA with the non-covalent Ǵ spin label. Nucleic Acids Research
Journal Article
77 (1), pp. 164 - 179 (2020)
Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB. Molecular Cell 2018
Journal Article
122 (49), pp. 11626 - 11639 (2018)
Dispersion Correction Alleviates Dye Stacking of Single-Stranded DNA and RNA in Simulations of Single-Molecule Fluorescence Experiments. The Journal of Physical Chemistry B
Journal Article
24 (66), pp. 17568 - 17576 (2018)
Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging. Chemistry – A European Journal 2017
Journal Article
139 (34), pp. 11674 - 11677 (2017)
Resolving the Conformational Dynamics of DNA with Ångstrom Resolution by Pulsed Electron–Electron Double Resonance and Molecular Dynamics. Journal of the American Chemical Society 2015
Journal Article
350 (6259), pp. 445 - 450 (2015)
Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation. Science Thesis - PhD (1)
2021
Thesis - PhD
Molecular Simulation and Modeling of Chemically Modified Nucleic Acids. Dissertation, 174 pp., Fachbereich Biochemie, Chemie und Pharmazie, Johann Wolfgang Goethe Universität, Frankfurt am Main (2021)
Thesis - Master (1)
2015
Thesis - Master
Protein Ligand Dynamics in Myoglobin. Master, 66 pp., Institut für Physikalische und Theoretische Chemie, Goethe-Universität Frankfurt, Frankfurt am Main (2015)