Intrinsic autophagy receptors
Macroautophagy (hereafter called autophagy) is able to sequester a wide range of cytosolic cargo such as invading pathogens, protein aggregates or damaged/disused organelles into newly synthesized double-membrane vesicles that fuse with a degradative compartment for breackdown. Recently, we uncovered a role of selective autophagy in degradation of macromolecular machines by the action of so-called intrinsic autophagy receptors, these are integral and functionally important subunits within normal complexes, but can if needed also direct them for autophagic degradation. Consequently, intrinsic autophagy receptors provide an in-built quality control that differs from conventional receptors, which become dynamically recruited. We are interested to systemically map and define the intrinsic receptor landscape in different species as well as to understand how these receptors distinguish the functional from the degradative state of a macromolecular complex.