DFG Collaborative Research Center 1507
Membrane-Associated Protein Assemblies, Machineries and Supercomplexes
Collaborative Research Centres (CRCs) are long-term university-based research institutions, established for up to 12 years, in which researchers work together within a multidisciplinary research programme.
The CRC 1507 “Protein Assemblies and Machinery in Cell Membranes,” coordinated at Goethe University Frankfurt am Main (Spokesperson: Robert Tampé) is a cooperation with the MPI of Biophysics, the Johannes Gutenberg University Mainz, and the Friedrich Schiller University Jena.
The MPI of Biophysics and Goethe University Frankfurt am Main have been working together on various biophysical research projects for years. The CRC 1507 strengthens this excellent local network and the successful collaboration between the institutes on Frankfurt’s Riedberg Campus.
CRC 1507 Key Data
Coordinating Institution: Goethe-University Frankfurt
Spokesperson: Prof. Dr. Robert Tampé
Funding Period: since 2022
Link to CRC Website
Link to DFG GEPRIS Data Base
Projects Conducted at the MPI of Biophysics
Investigator: Martin Beck in collaboration with Edward Lemke (University Mainz)
Term: 2022–2026
Martin Beck studies large protein complexes that form pores in the nuclear membrane and, thus, support the protection of the genomic integrity
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Investigator: Gerhard Hummer
Using molecular dynamics simulations and biomolecular modeling, Gerhard Hummer aids the understanding of protein complex assembly and conformational dynamics.
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Investigator: Melanie McDowell
Term: 2022–2026
Melanie McDowell studies the molecular mechanisms that control the delivery and correct insertion of membrane proteins at the endoplasmic reticulum (ER). The ER is an intermediate station for all membrane proteins where they undergo folding, modifications and assembly before trafficking to their final destination.
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Investigator: Bonnie Murphy
Term: 2022–2026
Bonnie Murphy investigates the structure and dynamics of microbial protein complexes from hydrogen- and methane-producing organisms, seeking to understand how these complexes couple redox reactions to generate a proton gradient across the membrane. This gradient is crucial for the cell’s energy metabolism.
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Investigator: Janet Vonck in collaboration with Volker Zickermann (Goethe-University)
Term: 2022–2026
Janet Vonck focusses on the assembly and function of a specific enzyme complex (complex I) involved in the respiratory chain, a process that is essential for the conversion of food to energy.
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