Vidhi Sehrawat

Vidhi Sehrawat

PhD Student

Research Experience

Dioscuri Centre for Modelling of Posttranslational Modifications
Malopolska Centre of Biotechnology
Krakow, PL | May 2023 – present

PhD in Biomedical Sciences

  • Doctoral research in collaboration with Max Planck Institute of Biophysics focusing on understanding the roleof glycans in neurotransmitter receptor dynamics
  • Utilising atomistic molecular dynamics simulations on polysaccharides and proteins1

Malopolska Centre of Biotechnology
Krakow, PL | Feb – Apr 2023

Research Intern

  • Expanded GlycoSHIELD glycan conformer library using atomistic GROMACS simulations and CHARMM-GUI
  • Automated post-processing and analyses steps in MD simulations using Python and Bash scripting

Selvita
Krakow, PL | Oct 2021 – Jun 2022

Synthetic Organic Chemist

  • Performed 100+ reactions for syntheses of 7+ targets in two international projects
  • Optimised leading oncology-focused macrocyclic structures for synthetic drug discovery experiments

Adam Mickiewicz University
Poznan, PL | Dec 2020 – Aug 2021

Thesis Research Intern (Erasmus Mundus Scholar)

  • Investigated oxidative stress in model methionine derivatives in Tomasz Pedzinski’s lab using 5+ spectroscopic techniques2
  • Ranked three out of 25 during thesis defence by the international jury with a 17.5/20.0 GPA

Department of Imaging Physics
TU Delft, Delft, NL | Jul – Sep 2020

Summer Research Intern

  • Expanded comparative studies on rhodopsins as voltage imaging sensors, leading to collaborative fluorescence imaging experiments in Brinks Lab and a departmental seminar presentation

Institute of Physical Chemistry
CNRS, Orsay, FR | Jan – Feb 2020

Research Intern

  • Designed a new vector via gene cloning in Marie Erard’s lab for enhanced yellow fluorescent protein (YFP) in eukaryotic cells with 2x expression accuracy

Freelance
Sep 2019 – present

Career Mentor

  • Mentored 300+ students with personalised support in writing successful academic admission applications
  • Invited as a guest speaker at the Erasmus Pre-Departure Sessions of 2020 and 2022 by the Delegation of the EU to India and Bhutan

Indian Institute of Scientific Education and Research (IISER)
Bhopal, IN | May –Aug 2018

IAS Summer Research Fellow

  • Synthesised and characterised ester derivatives for enantioselective synthesis of isoindolinones derivatives in V.K. Singh Group using one-pot three-component Mannich alkylation

Publications

Tsai, Y.; ….; Sehrawat, V.; ….; Hummer, G.; Hsu, S. D.; Hanus, C.; Sikora, M.
Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries.
Cell 187 (5), pp. 1296 - 1311 (2024).
DOI
Grzyb, K.; Sehrawat, V.; Pedzinski, T.
The Fate of Sulfur Radical Cation of N-Acetyl-Methionine: Deprotonation vs. Decarboxylation.
Photochem 3 (1), pp. 98 - 108 (2023).
DOI
Al-Otaibi et al.
Sample preparation in single particle cryo-EM: general discussion.
Faraday Discussions 240 (2022).
DOI
Bakker et al.
Map/model validation and machine learning in EM: general discussion.
Faraday Discussions 240 (2022).
DOI

Education

  • Dual M.Sc. Chemistry
    Erasmus Mundus SERP+: Paris-Saclay University, Orsay, FR and Adam Mickiewicz
    University, Poznan, PL (2021).
  • CGPA 4.8/5.0 | Magna cum laude
    B.Sc. (Honours) Chemistry
    St. Stephen’s College, University of Delhi, Delhi, IN (2019).
  • CGPA 9.0/10.0 | Summa cum laude
    AISSCE (High School)
    Ganga International School, Delhi, IN (2016).
  • 96.2%
    Top 1% nationwide in Central Board of Secondary Education (CBSE) examination
    Summa cum laude

Awards

  • STEM student grant
    to attend “Perspektywy Women in Tech Summit”, the largest conference for women in technology in Europe and Asia taking place in Warsaw, PL (2024)
  • Research Support Module grant
    Jagiellonian University. (2023)
  • COST Action INNOGLY travel grant
    European Cooperation in Science and Technology (COST) (2023).
  • Associate membership
    The Royal Society of Chemistry, London, GB (2019 – present).
  • Erasmus Mundus Scholarship
    European Union (2019 – 21).
  • Summer Research Fellowship Program (SRFP)
    The Indian Academy of Sciences (IAS) and Indian National Science Academy (INSA) (2018).
  • Meritorious Award
    Faculty of Science, University of Delhi, New Delhi, IN (2017 – 18).
  • INSPIRE – Scholarship for Higher Education
    Department of Science and Technology, Government of India (2016 – 19).

Leadership Positions

  • Organiser and Founding Committee Member
    Environmental Awareness Day organised at Paris-Saclay University, Orsay, FR (2019 – 20).
  • President
    Chemistry Society, St. Stephen’s College, New Delhi, IN (2018 – 19).
  • National Conference Coordinator
    Charusita Memorial Lectures, Conference on Emerging Trends and Advances in Chemical Sciences (ETACS), and National Conference in Chemical Sciences (NCCS), St. Stephen’s College, New Delhi, IN (2018 – 19).
  • Head of External Affairs
    Photographic Society, St. Stephen’s College, New Delhi, IN (2018 – 19).
  • Treasurer
    Chemistry Society, St. Stephen’s College, New Delhi, IN (2017 – 18).

Scientific Events

Poster presentations:

  1. Distinction prize
    2nd “Interdisciplinary PhD Symposium”
    Doctoral School of Exact and Natural Sciences (2024, Krakow, PL).
  2. “MD@60”
    Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) and European Center for Atomistic and Molecular Calculations (CECAM) (2024, Bengaluru, IN).
  3. “Paths of Glycobiology: Jerzy Kościelak Memorial Conference”
    Hirszfeld Institute of Immunology and Experimental Therapy and Wrocław University of Environmental and Life Sciences (2023, Wroclaw, PL).
  4. 8th edition of “Conference on Biomolecules and Nanostructures”
    Institute of Physics, Polish Academy of Sciences (PAN) (2023, Krakow, PL).
  5. “Science: Polish Perspectives”
    Polonium Foundation (2021, Zurich, CH).
  6. “International Conference on Integrative Biology and Translational Medicine (ICIBTM)”
    Hansraj College, University of Delhi (2019, New Delhi, IN)
  7. “National Science Day” event
    Indian National Science Academy (2018, New Delhi, IN).

Talks and oral presentations:

  1. Scientific outreach talk
    “A Green Molecular Dynamics-Based Approach to Explore the World of Glycans”
    St. Stephen’s College (2024, New Delhi, IN).
  2. Flash talk
    BioExcel Summer School on Biomolecular Simulations (2023, Pula, IT).
  3. “Bronsted Acid-Catalyzed Syntheses of Highly Substituted Isoindolinones”
    National Conference ETACS, St. Stephen’s College (2018, New Delhi, IN).
  4. “How can India continue to meet its increasing demand for paper without affecting the precious few rainforests present in the country?”
    Greening an Undergraduate Chemistry Lab (GUCL) – Creating Awareness for Environmental Friendly Methodologies, Sri Venkateswara College (2018, New Delhi, IN).

Summer Schools:

  1. BioExcel Summer School on Biomolecular Simulations
    BioExcel and Sardegna Ricerche (2023, Pula, IT).
  2. Structural Glycoscience Summer School
    Glyco@Alps CDP project, University of Grenoble-Alpes, COST Action INNOGLY and GlycoNanoProbes (2023, Grenoble, FR).
  3. School on Science Management for Scientists and Engineers (SoSMSE)
    Erasmus Mundus SERP+ and University of Genoa (2021, Genoa, IT)
  4. Summer School on Large-Scale Facilities for Global Health
    by European University Alliance for Global Health (EUGLOH) Consortium (2020, Paris, FR)

Courses

  • Empowering Women Through Entrepreneurship Program
    Indian Institute of Management (IIM) Bangalore
  • Creative Coding using p5.js
    New York University (NYU) Tandon School of Engineering
  • Intro to Programming
    Kaggle
  • Basic Microbiology
    World Health Organization (WHO)
  • Principles of Cell Line Development
    Cytiva
  • Exploring Issues in Women’s Health
    Open University

Skills

Computational:
High-performance computing (HPC), Python3, Bash, JupyterLab, Conda, NumPy, Pandas, MatPlotLib, Slurm, GROMACS, AlphaFold2, JChem, Modeller, OriginPro, MS Office 365, Mendeley, PyMOL, VMD, ChimeraX.

Experimental:
Time-resolved spectroscopy, Nanosecond laser flash photolysis (nsLFP), Organic synthesis, Route development and optimisation, Chromatography (HPLC, LC, Flash, Column, Thin Layer), NMR (1H and 13C), FTIR, MS/MS, Cell culture development, Gel electrophoresis, Recombinant DNA technology, Plasmid engineering, Optical Microscopy.

Languages:
English (C2), Polish (A2), Hindi (C2), French (A1).

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