DFG Collaborative Research Center 1218

Mitochondrial regulation of cellular function

The Collaborative Research Centre (CRC)/Sonderforschungsbereich (SFB) 1218 on Mitochondrial regulation of cellular function has been funded by the German Research Foundation (DFG) since July 2016. A group of scientists from the University of Cologne,  the Max Planck Institute for Biology of Ageing, the Max Planck Institute for Metabolism Research in Cologne and  from the University of Bonn have teamed up to study how mitochondria influence activity, differentiation and survival of the cell.

 

Ana J. García-Sáez leads project part A12 - Dynamic architecture of DRP1 macromolecular assemblies in mitochondrial fission

This project aims to shed light on the molecular mechanism and dynamic behavior of DRP1 assemblies in mitochondrial fission. We will investigate the nanoscale organization of DRP1 complexes and their dynamics of interaction with mitochondria. Building on preliminary microscopy data, we will dissect the molecular mechanisms underlying mobility of DRP1 complexes and how DRP1 dynamics are functionally linked to mitochondrial fission. We will further characterize how DRP1 complexes are affected by mitochondrial adaptors and by mitochondrial stress.

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