Publications of Irene Schulz

Journal Article (69)

1992
Journal Article
Zimmermann, P.; Schnefel, S.; Zeuzem, S.; Pröfrock, A.; Haase, W.; Schulz, I.: Effects of agonists on p21ras and ras-related proteins in rat pancreatic acinar cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 263 (3 Pt 1), pp. G396 - G406 (1992)
Journal Article
Zeuzem, S.; Schulz, I.; Caspary, W. F.: GTP-bindende Proteine in der Pathophysiologie innerer Erkrankungen. Deutsches Ärzteblatt 89 (34-35), pp. A1;2768 - A1;2774 (1992)
Journal Article
Pröfrock, A.; Zimmermann, P.; Schulz, I.: Bombesin receptors interact with Gi and p21ras proteins in plasma membranes from rat pancreatic acinar cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 263 (2 Pt 1), pp. G240 - G247 (1992)
Journal Article
Zeuzem, S.; Feick, P.; Zimmermann, P.; Haase, W.; Khan, R. A.; Schulz, I.: Intravesicular acidification correlates with binding of ADP-ribosylation factor to microsomal membranes. Proceedings of the National Academy of Sciences of the United States of America 89 (14), pp. 6619 - 6623 (1992)
Journal Article
Zeuzem, S.; Zimmermann, P.; Schulz, I.: Association of a 19- and a 21-kDa GTP-binding protein to pancreatic microsomal vesicles is regulated by the intravesicular pH established by a vacuolar-type H+-ATPase. Journal of Membrane Biology 125 (3), pp. 231 - 241 (1992)
Journal Article
Schnefel, S.; Zimmermann, P.; Pröfrock, A.; Jahn, B.; Aktories, K.; Zeuzem, S.; Haase, W.; Schulz, I.: High- and Small-Molecular-Weight GTP-Binding Proteins in Zymogen Granule Membranes of Rat Pancreatic Acinar Cells. Cellular Physiology and Biochemistry 2 (2), pp. 77 - 89 (1992)
1991
Journal Article
Piiper, A.; Pröfrock, A.; Schulz, I.: Effects of epidermal growth factor and calcium omission on cholecystokinin-stimulated Cl conductance in rat pancreatic zymogen granules. Biochemical and Biophysical Research Communications 181 (2), pp. 827 - 832 (1991)
Journal Article
Plusczyk, T.; Piiper, A.; Schulz, I.: PGE2 regulates cholecystokinin-octapeptide (CCK-8)-stimulated Cl conductance in isolated zymogen granules from rat pancreas. FEBS Letters 295 (1), pp. 89 - 92 (1991)
Journal Article
Ozawa, T.; Schulz, I.: H+ uptake increases GTP-induced connection of inositol 1,4,5-trisphosphate- and caffeine-sensitive calcium pools in pancreatic microsomal vesicles. Biochemical and Biophysical Research Communications 180 (2), pp. 755 - 764 (1991)
Journal Article
Pröfrock, A.; Piiper, A.; Eckhardt, L.; Schulz, I.: Epidermal growth factor inhibits both cholecystokinin octapeptide-induced inositol 1,4,5-trisphosphate production and [Ca2+]i increase in rat pancreatic acinar cells. Biochemical and Biophysical Research Communications 180 (2), pp. 900 - 906 (1991)
Journal Article
Zeuzem, S.; Zimmermann, P.; Schulz, I.: Guanosine nucleotides modulate the inhibitory effect of brefeldin A on protein secretion. FEBS Letters 288 (1-2), pp. 143 - 146 (1991)
Journal Article
Piiper, A.; Plusczyk, T.; Eckhardt, L.; Schulz, I.: Effects of cholecystokinin, cholecystokinin JMV-180 and GTP analogs on enzyme secretion from permeabilized acini and chloride conductance in isolated zymogen granules of the rat pancreas. European Journal of Biochemistry 197 (2), pp. 391 - 398 (1991)
Journal Article
Pröfrock, A.; Schnefel, S.; Schulz, I.: Receptors for insulin interact with Gi-proteins and for epidermal growth factor with Gi- and Gs-proteins in rat pancreatic acinar cells. Biochemical and Biophysical Research Communications 175 (2), pp. 380 - 386 (1991)
Journal Article
Dehlinger-Kremer, M.; Zeuzem, S.; Schulz, I.: Interaction of caffeine-, IP3- and vanadate-sensitive Ca2+ pools in acinar cells of the exocrine pancreas. Journal of Membrane Biology 119 (1), pp. 85 - 100 (1991)
1990
Journal Article
Schäfer, R.; Nehls-Sahabandu, M.; Grabowsky , B.; Dehlinger-Kremer, M.; Schulz, I.; Mayr, G. W.: Synthesis and application of photoaffinity analogues of inositol 1,4,5-trisphosphate selectively substituted at the 1-phosphate group. Biochemical Journal 272 (3), pp. 817 - 825 (1990)
Journal Article
Hampe, W.; Zimmermann, P.; Schulz, I.: GTP-induced fusion of isolated pancreatic microsomal vesicles is increased by acidification of the vesicle lumen. FEBS Letters 271 (1-2), pp. 62 - 66 (1990)
Journal Article
Schmid, A.; Dehlinger-Kremer, M.; Schulz, I.; Gögelein, H.: Voltage-dependent InsP3-insensitive calcium channels in membranes of pancreatic endoplasmic reticulum vesicles. Nature 346 (6282), pp. 374 - 376 (1990)
Journal Article
Schnefel, S.; Pröfrock, A.; Hinsch, K. D.; Schulz, I.: Cholecystokinin activates Gi1-, Gi2-, Gi3- and several Gs-proteins in rat pancreatic acinar cells. Biochemical Journal 269 (2), pp. 483 - 488 (1990)
1989
Journal Article
Fuller, C. M.; Deetjen, H. H.; Piiper, A.; Schulz, I.: Secretagogue and second messenger-activated Cl permeabilities in isolated pancreatic zymogen granules. Pflügers Archiv: European Journal of Physiology 415, pp. 29 - 36 (1989)
Journal Article
Schulz, I.; Thévenod, F.; Dehlinger-Kremer, M.: Modulation of intracellular free Ca2+ concentration by IP3-sensitive and IP3-insensitive nonmitochondrial Ca2+ pools. Cell Calcium 10 (5), pp. 325 - 336 (1989)
Journal Article
Thévenod, F.; Dehlinger-Kremer, M.; Kemmer, T. P.; Christian, A.-L.; Potter, B. V. L.; Schulz, I.: Characterization of inositol 1,4,5-trisphosphate-sensitive (IsCaP) and-insensitive (IisCaP) nonmitochondrial Ca2+ pools in rat pancreatic acinar cells. Journal of Membrane Biology 109, pp. 173 - 186 (1989)
Journal Article
Thévenod, F.; Kemmer, T. P.; Christian, A.-L.; Schulz, I.: Characterization of MgATP-Driven H+ uptake in to a microsomal vesicle franction from rat pancreatic acinar cells. Journal of Membrane Biology 107, pp. 263 - 275 (1989)
Journal Article
Fuller, C. M.; Eckhardt, L.; Schulz, I.: Ionic and osmotic dependence of secretion from permeabilised acini of the rat pancreas. Pflügers Archiv: European Journal of Physiology 413, pp. 385 - 394 (1989)
Journal Article
Schulz, I.; Thévenod, F.; Schnefel, S.; Schäfer, R.: Regulation mechanisms of receptors mediated activation of phospholipase c and inositol-1,4,5-triphosphate sensitive Ca2+ release and Ca2+ uptake in exocrine glandular cells. Arzneimittel-Forschung/Drug Research 39 (1A), pp. 168-7 - 177 (1989)
1988
Journal Article
Thévenod, F.; Schulz, I.: H+-dependent calcium uptake into an IP3-sensitive calcium pool from rat parotid gland. American Journal of Physiology 255 ((4 Pt 1)), pp. G429 - G440 (1988)
Journal Article
Schäfer, R.; Christian, A.-L.; Schulz, I.: Photoaffinity labeling with GTP-γ-azidoanilide of a cholera toxin-sensitive 40 kDa protein from pancreatic acinar cells. Biochemical and Biophysical Research Communications 155 (2), pp. 1051 - 1059 (1988)
Journal Article
Schnefel, S.; Banfic, H.; Eckhardt, L.; Schultz, G.; Schulz, I.: Acetylcholine and cholecystokinin receptors functionally couple by different G‐proteins to phospholipase C in pancreatic acinar cells. FEBS Letters (1-2), pp. 125 - 130 (1988)
1987
Journal Article
Kemmer, T. P.; Bayerdörffer, E.; Will, H.; Schulz, I.: Anion dependence of Ca2+ transport and (Ca2+ + K+)-stimulated Mg2+-dependent transport ATPase in rat pancreatic endoplasmic reticulum. The Journal of Biological Chemistry 262 (28), pp. 13758 - 13764 (1987)
1986
Journal Article
Schulz, I.; Schnefel, S.; Banfić, H.; Eckhardt, L.: Ca2+ signalling in exocrine glands in comparison to that in vascular smooth muscle cells. Annals of the New York Academy of Sciences 488 (1), pp. 240 - 251 (1986)
Journal Article
Kimura, T.; Imamura, K.; Eckhardt, L.; Schulz, I.: Ca2+-, phorbol ester-, and cAMP-stimulated enzyme secretion from permeabilized rat pancreatic acini. American Journal of Physiology-Gastrointestinal and Liver Physiology 250 (5 Pt 1), pp. G698 - G708 (1986)
Journal Article
Thévenod, F.; Streb, H.; Ullrich, K. J.; Schulz, I.: Inositol 1,4,5-trisphosphate releases Ca2+ from a nonmitochondrial store site in permeabilized rat cortical kidney cells. Kidney International 29 (3), pp. 695 - 702 (1986)
Journal Article
Schulz, I.; Streb, H.; Bayerdörffer, E.; Imamura, K.: Intracellular messengers in stimulus-secretion coupling of pancreatic acinar cells. Journal of Cardiovascular Pharmacology and Therapeutics 8 (Suppl 8), pp. S91 - S96 (1986)
1985
Journal Article
Imamura, K.; Schulz, I.: Phosphorylated intermediate of (Ca2+ + K+)-stimulated Mg2+-dependent transport ATPase in endoplasmic reticulum from rat pancreatic acinar cells. The Journal of Biological Chemistry 260 (20), pp. 11339 - 11347 (1985)
Journal Article
Hellmessen, H.; Christian, A.-L.; Fasold, H.; Schulz, I.: Coupled Na+-H+ exchange in isolated acinar cells from rat exocrine pancreas. American Journal of Physiology-Gastrointestinal and Liver Physiology 249 (1 Pt 1), pp. G125 - G136 (1985)
Journal Article
Streb, H.; Heslop, J. P.; Irvine, R. F.; Schulz, I.; Berridge, M. P.: Relationship between secretagogue-induced Ca2+ release and inositol polyphosphate production in permeabilized pancreatic acinar cells. The Journal of Biological Chemistry 260 (12), pp. 7309 - 7315 (1985)
Journal Article
Bayerdörffer, E.; Haase, W.; Schulz, I.: Na+/Ca2+ countertransport in plasma membrane of rat pancreatic acinar cells. Journal of Membrane Biology 87 (2), pp. 107 - 119 (1985)
Journal Article
Schulz, I.; Streb, H.; Bayerdörffer, E.; Thévenod, F.: Stimulus-secretion coupling in exocrine glands: the role of inositol-1,4,5-trisphosphate, calcium and cAMP. Current Eye Research 4 (4), pp. 467 - 473 (1985)
Journal Article
Bayerdörffer, E.; Eckhardt, L.; Haase, W.; Schulz, I.: Electrogenic calcium transport in plasma membrane of rat pancreatic acinar cells. Journal of Membrane Biology 84 (1), pp. 45 - 60 (1985)
1984
Journal Article
Streb, H.; Bayerdörffer, E.; Haase, W.; Irvine, R. F.; Schulz, I.: Effect of inositol-1,4,5-trisphosphate on isolated subcellular fractions of rat pancreas. Journal of Membrane Biology, pp. 241 - 253 (1984)
Journal Article
Bayerdörffer, E.; Streb, H.; Eckhardt, L.; Haase, W.; Schulz, I.: Characterization of calcium uptake into rough endoplamic reticulum of rat pancreas. Journal of Membrane Biology 81 (1), pp. 69 - 82 (1984)
1983
Journal Article
Streb, H.; Irvine, R. F.; Berridge, M. P.; Schulz, I.: Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 309, pp. 67 - 69 (1983)
Journal Article
Streb, H.; Schulz, I.: Regulation of cytosolic free Ca2+ concentration in acinar cells of rat pancreas. American Journal of Physiology-Gastrointestinal and Liver Physiology 245 (3), pp. G347 - G357 (1983)
Journal Article
Kribben, A.; Tyrakowski, T.; Schulz, I.: Characterization of Mg-ATP-dependent Ca2+ transport in cat pancreatic microsomes. American Journal of Physiology-Gastrointestinal and Liver Physiology 244 (5), pp. G480 - G490 (1983)
1982
Journal Article
Kribben, A.; Schulz, I.: Mg2+‐dependent Ca2+ transport in cell membranes from the exocrine pancreas. Annals of the New York Academy of Sciences 402 (1), pp. 443 - 444 (1982)
Journal Article
Wakasugi, H.; Kimura, T.; Haase, W.; Kribben, A.; Kaufmann, R.; Schulz, I.: Calcium uptake into acini from rat pancreas: evidence for intracellular ATP-dependent calcium sequestration. Journal of Membrane Biology 65 (3), pp. 205 - 220 (1982)
1981
Journal Article
Schulz, I.; Kimura, T.; Wakasugi, H.; Haase, W.; Kribben, A.: Analysis of Ca2+ fluxes and Ca2+ pools in pancreatic acini. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 296 (1080), pp. 105 - 113 (1981)
Journal Article
Schulz, I.; Wakasugi, H.; Stolze, H. H.; Kribben, A.; Haase, W.: Analysis of Ca2+ fluxes and their relation to enzyme secretion in dispersed pancreatic acinar cells. Federation proceedings 40 (10), pp. 2503 - 2510 (1981)
Journal Article
Wakasugi, H.; Stolze, H. H.; Haase, W.; Schulz, I.: Effect of La3+ on secretagogue-induced Ca2+ fluxes in rat isolated pancreatic acinar cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 240 (4), pp. G281 - G289 (1981)
1980
Journal Article
Schulz, I.: Bicarbonate transport in the exocrine pancreas. Annals of the New York Academy of Sciences 341 (1), pp. 191 - 209 (1980)
Journal Article
Stolze, H. H.; Schulz, I.: Effect of atropine, ouabain, antimycin A, and A23187 on "trigger Ca2+ pool" in exocrine pancreas. American Journal of Physiology-Gastrointestinal and Liver Physiology 238 (4), pp. G338 - G348 (1980)
Journal Article
Moroder, L.; Jaeger, E.; Drees, F.; Gemeiner, M.; Knof, S.; Stelzel, H.-P.; Thamm, P.; Bataille, D.; Domschke, S.; Schlegel, W. et al.; Schulz, I.; Wünsch, E.: Structure-function studies on gastrointestinal hormones: I. Synthesis of secretin analogs and their biological and immunological properties. Bioorganic Chemistry 9 (1), pp. 27 - 54 (1980)
Journal Article
Schulz, I.; Stolze, H. H.: The exocrine pancreas: the role of secretagogues, cyclic nucleotides, and calcium in enzyme secretion. Annual Review of Physiology 42, pp. 127 - 156 (1980)
1979
Journal Article
Schulz, I.; Heil, K.: Ca2+ control of electrolyte permeability in plasma membrane vesicles from cat pancreas. Journal of Membrane Biology 46 (1), pp. 41 - 70 (1979)
1978
Journal Article
Tyrakowski, T.; Milutinović, S.; Schulz, I.; Hornung, C.; Heil, K.; Wiechmann, J.: Studies on isolated subcellular components of cat pancreas. III. Alanine-sodium cotransport in isolated plasma membrane vesicles. Journal of Membrane Biology 38 (4), pp. 333 - 346 (1978)
1977
Journal Article
Milutinović, S.; Argent, B. E.; Schulz, I.; Sachs, G.: Studies on isolated subcellular components of cat pancreas. II. A Ca++-dependent interaction between membranes and zymogen granules of cat pancreas. Journal of Membrane Biology 36 (2-3), pp. 281 - 295 (1977)
Journal Article
Milutinović, S.; Sachs, G.; Haase, W.; Schulz, I.: Studies on isolated subcellular components of cat pancreas. I. Isolation and enzymatic characterization. Journal of Membrane Biology 36 (2-3), pp. 253 - 279 (1977)
Journal Article
Koelz, H. R.; Kondo, S.; Blum, A.L.; Schulz, I.: Calcium ion uptake induced by cholinergic and α-adrenergic stimulation in isolated cells of rat salivary glands. Pflügers Archiv: European Journal of Physiology 370 (1), pp. 37 - 44 (1977)
1976
Journal Article
Kondo, S.; Schulz, I.: Ca++ fluxes in isolated cells of rat pancreas. Effect of secretagogues and different Ca++ concentrations. Journal of Membrane Biology 29 (1-2), pp. 185 - 203 (1976)
Journal Article
Milutinović, S.; Schulz, I.; Rosselin, G.: The interaction of secretin with pancreatic membranes. Biochimica et Biophysica Acta-Biomembranes 436 (1), pp. 113 - 127 (1976)
Journal Article
Kondo, S.; Schulz, I.: Calcium ion uptake in isolated pancreas cells induced by secretagogues. Biochimica et Biophysica Acta-Biomembranes 419 (1), pp. 76 - 92 (1976)
1975
Journal Article
Schulz, I.: The role of extracellular Ca2+ and cyclic nucleotides in the mechanism of enzyme secretion from the cat pancreas. Pflügers Archiv: European Journal of Physiology 360 (2), pp. 165 - 181 (1975)
1974
Journal Article
Schulz, I.; Mannigel, H.: Dependence of pancreatic enzyme secretion on extracellular Ca++ and its modification by cyclic nucleotides and thyrocalcitonin. Acta Gastro-Enterologica Belgica 37 (9), pp. 402 - 412 (1974)
Journal Article
Pederson, R.; Schulz, I.: The effect of isoproterenol on enzyme secretion from the isolated perfused cat pancreas. Biochimica et Biophysica Acta (BBA) - General Subjects 338 (2), pp. 440 - 446 (1974)
Journal Article
Wizemann, V.; Christian, A.-L.; Wiechmann, J.; Schulz, I.: The distribution of membrane bound enzymes in the acini and ducts of the cat pancreas. Pflügers Archiv: European Journal of Physiology 347 (1), pp. 39 - 47 (1974)
1973
Journal Article
Wizemann, V.; Schulz, I.: Influence of Amphotericin, Amiloride, Ionophores, and 2,4-Dinitrophenol on the secretion of the isolated cat's pancreas. Pflügers Archiv: European Journal of Physiology 339, pp. 317 - 338 (1973)
Journal Article
Wizemann, V.; Schulz, I.; Simon, B. J.: SH-groups on the surface of pancreas cells involved in secretin stimulation and glucose-mediated secretion. Biochimica et Biophysica Acta-Biomembranes 307 (2), pp. 366 - 371 (1973)
1971
Journal Article
Schulz, I.: Influence of bicarbonate-CO2- and glycodiazine buffer on the secretion of the isolated cat's pancrea. Pflügers Archiv: European Journal of Physiology 329 (4), pp. 283 - 306 (1971)
Journal Article
Schulz, I.; Ströver, F.; Ullrich, K. J.: Lipid soluble weak organic acid buffers as "substrate" for pancreatic secretion. Pflügers Archiv: European Journal of Physiology 323 (2), pp. 121 - 140 (1971)
1969
Journal Article
Schulz, I.; Yamagata, A.; Weske, M.: Micropuncture studies on the pancreas of the rabbit. Pflügers Archiv: European Journal of Physiology 308, pp. 277 - 290 (1969)

Book Chapter (5)

1990
Book Chapter
Schulz, I.: Permeabilizing cells: Some methods and applications for the study of intracellular processes. In: Methods in Enzymology, Vol. 192, pp. 280 - 300 (Eds. Fleischer, S.; Fleischer, B.). Academic Press; Elsevier Inc (1990)
1987
Book Chapter
Schulz, I.: Electrolyte and fluid secretion in the exocrine pancreas. In: Physiology of the gastrointestinal tract, 2nd edition Ed., pp. 1147 - 1171 (Ed. Johnson, L. R.). Raven Press, New York (1987)
Book Chapter
Schulz, I.; Schnefel, S.; Banfić, H.; Thévenod, F.; Kemmer, T. P.; Eckhardt, L.: The role of phosphatidylinositides in stimulus-secretion coupling in the exocrine pancreas. In: Society of General Physiologists Series, Vol. 42, pp. 117 - 131 (1987)
1986
Book Chapter
Schulz, I.: Regulation of Enzyme, Electrolyte, and Fluid Secretion in the Exocrine Pancreas. In: Diagnostic Procedures in Pancreatic Disease, pp. 195 - 200 (Eds. Malfertheiner, P.; Ditschuneit, H.). Springer-Verlag, Berlin, Heidelberg (1986)
Book Chapter
Schulz, I.: Signaling Transduction in Hormone‐ and Neurotransmitter‐Induced Enzyme Secretion from the Exocrine Pancreas. In: Comprehensive Physiology, Vol. III, pp. 443 - 463. American Physiological Society, Bethesda, MD, USA (1986)

Conference Paper (3)

1988
Conference Paper
Schulz, I.; Schnefel, S.; Schäfer, R.: Regulation of Signal Transduction by G Proteins in Exocrine Pancreas Cells. In: The Calcium Channel: Structure, Function and Implications, pp. 363 - 371 (Eds. Morad, M.; Nayler, W. G.; Kazda, S.; Schramm, M.). Bayer AG Centenary Symposium, Stresa, Italy, May 11, 1988 - May 14, 1988. Springer-Verlag, Berlin, Heidelberg (1988)
1977
Conference Paper
Schulz, I.; Milutinović, S.: High Affinity SH-Groups on the Surface of Pancreas Cells Involved in Secretin Stimulation. Proceedings of the Ninth Annual Rochester International Conference on Environmental Toxicity , Rochester, New York, May 24, 1976 - May 26, 1976. Advances in Experimental Medicine and Biology 84, pp. 209 - 227 (1977)
1974
Conference Paper
Schulz, I.; Pederson, R.; Kondo, S.: Stimulatory processes of the exocrine pancreas and their inhibition by a non-penetrating SH-reagent. In: Secretory mechanisms of exocrine glands, pp. 88 - 95 (Eds. Thorn, N. A.; Petersen, O. H.). Proceedings of the Alfred Benzon Symposium VII, Premises of the Royal Danish Academy of Sciences and Letters, Copenhagen, September 09, 1973 - September 12, 1973. Academic Press, New York (1974)

Thesis - Habilitation (1)

1975
Thesis - Habilitation
Schulz, I.: Die Rolle von Calciumionen und cyclischen Nukleotiden bei der Enzymsekretion im Pankreas. Habilitation, Fachbereich Physiologie, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt am Main (1975)

Editorial (1)

1980
Editorial
Schulz, I.: Messenger role of calcium in function of pancreatic acinar cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 239 (5), pp. G335 - G347 (1980)
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