Werner Kühlbrandt

2025

Journal Article

Blum, T. B.; Davies, K. M.; Kühlbrandt, W.: Subtomogram averages of mitochondrial ATP synthase dimers from plants show a conserved extra density at the peripheral stalk. IUCrJ 12, pp. 563 - 569 (2025)

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Agip, A.-N. A.; Ornelas, P.; Yang, T.-J.; Uboldi, E.; Häder, S.; McDowell, M.; Kühlbrandt, W.: Structures of Chaetomium thermophilum TOM complexes with bound preproteins. Proceedings of the National Academy of Sciences of the United States of America 122 (29), e2507279122 (2025)

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Singh, M. K.; Cavellini, L.; Morcillo-Parra, M. A.; Kunz, C.; Lelek, M.; Bomme, P.; Barascu, A.; Alsayyah, C.; Teixeira, M. T.; Belgareh-Touzé, N. et al.; Mallet, A.; Dietrich, L.; Zimmer, C.; Cohen, M. M.: A constricted mitochondrial morphology formed during respiration. Nature Communications 16, 5314 (2025)

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Buckel, W.; Ermler, U.; Vonck, J.; Fritz, G.; Steuber, J.: The RNF/NQR redox pumps: a versatile system for energy transduction in bacteria and archaea. Applied Microbiology and Biotechnology 109, 148 (2025)

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Lafargue, E.; Duneau, J.-P.; Buzhinsky, N.; Ornelas, P.; Ortega, A.; Ravishankar, V.; Sturgis, J.; Casuso, I.; Bergdoll, L.: Membrane lipid composition modulates the organization of VDAC1, a mitochondrial gatekeeper. Communications Biology 8, 936 (2025)

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Introini, B.; Hahn, A.; Kühlbrandt, W.: Cryo-EM structure of the NDH-PSI-LHCI supercomplex from Spinacia oleracea. Nature Structural & Molecular Biology 32 (6), pp. 968 - 978 (2025)

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Stautz, J.; Griwatz, D.; Kaltwasser, S.; Mehdipour, A. R.; Ketter, S.; Thiel, C.; Wunnicke, D.; Schrecker, M.; Mills, D. J.; Hummer, G. et al.; Vonck, J.; Hänelt, I.: A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K⁺ channel KtrAB. Nature Communications 16, 4252 (2025)

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Kühlbrandt, W.; Carreira, L. A. M.; Yildiz, Ö.: Cryo-EM of Mitochondrial Complex I and ATP Synthase. Annual Review of Biophysics 54, pp. 209 - 226 (2025)

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Lee, Y.; Jin, C.; Ohgaki, R.; Xu, M.; Ogasawara, S.; Warshamanage, R.; Yamashita, K.; Murshudov, G.; Nureki, O.; Murata, T. et al.; Kanai, Y.: Structural basis of anticancer drug recognition and amino acid transport by LAT1. Nature Communications 16, 1635 (2025)

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Periasamy, A.; Ornelas, P.; Bausewein, T.; Mitchell, N.; Zhao, J.; Quinn, L. M.; Kuehlbrandt, W.; Gulbis, J. M.: Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM. IUCrJ 12 (1) (2025)

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2024

Journal Article

Wilm, M.: Nanoelectrospray based synthesis of large, transportable membranes with integrated membrane proteins. Scientific Reports 14, 25192 (2024)

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Dietrich, L.; Agip, A.-N. A.; Kunz, C.; Schwarz, A.; Kühlbrandt, W.: In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells. Science 385 (6713), pp. 1086 - 1090 (2024)

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Schneider, S.; Kühlbrandt, W.; Yildiz, Ö.: Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism. Structure 32 (7), pp. 979 - 988.e4 (2024)

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Adolph, C.; Cheung, C.-Y.; McNeil, M. B.; Jowsey, W. J.; Williams, Z. C.; Hards, K.; Harold, L. K.; Aboelela, A.; Bujaroski, R. S.; Buckley, B. J. et al.; Tyndall, J. D. A.; Li, Z.; Langer, J. D.; Preiss, L.; Meier, T.; Steyn, A. J. C.; Rhee, K. Y.; Berney, M.; Kelso, M. J.; Cook, G. M.: A dual-targeting succinate dehydrogenase and F₁F_o-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chemical Biology 31, pp. 683 - 698.e7 (2024)

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Journal Article

Aziz, I.; Kayastha, K.; Kaltwasser, S.; Vonck, J.; Welsch, S.; Murphy, B. J.; Kahnt, J.; Wu, D.; Wagner, T.; Shima, S. et al.; Ermler, U.: Structural and mechanistic basis of the central energy-converting methyltransferase complex of methanogenesis. PNAS 121 (14), e2315568121 (2024)

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Lasham, J.; Djurabekova, A.; Zickermann, V.; Vonck, J.; Sharma, V.: Role of Protonation States in the Stability of Molecular Dynamics Simulations of High-Resolution Membrane Protein Structures. The Journal of Physical Chemistry B 128 (10), pp. 2304 - 2316 (2024)

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Laube, E.; Schiller, J.; Zickermann, V.; Vonck, J.: Using cryo-EM to understand the assembly pathway of respiratory complex I. Acta Crystallographica Section D: Structural Biology 80, pp. 159 - 173 (2024)

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Centola, M.; Poppleton, E.; Ray, S.; Centola, M.; Welty, R.; Valero, J.; Walter, N. G.; Šulc, P.; Famulok, M.: A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower. Nature Nanotechnology 19 (2), pp. 226 - 236 (2024)

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Gewering, T.; Waghray, D.; Parey, K.; Jung, H.; Tran, N. N. B.; Zapata, J.; Zhao, P.; Chen, H.; Januliene, D.; Hummer, G. et al.; Urbatsch, I.; Moeller, A.; Zhang, Q.: Tracing the substrate translocation mechanism in P-glycoprotein. eLife 12, RP90174 (2024)

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Braun, H.-P.; Klusch, N.: Promotion of oxidative phosphorylation by complex I-anchored carbonic anhydrases? Trends in Plant Science 29 (1), pp. 64 - 71 (2024)

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Lasham, J.; Djurabekova, A.; Kolypetris, G.; Zickermann, V.; Vonck, J.; Sharma, V.: Assessment of amino acid charge states based on cryo-electron microscopy and molecular dynamics simulations of respiratory complex I. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1866 (1), 149512 (2024)

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2023

Journal Article

Hau, J.-L.; Kaltwasser, S.; Muras, V.; Casutt, M. S.; Vohl, G.; Claußen, B.; Steffen, W.; Leitner, A.; Bill, E.; Cutsail, G. E. et al.; DeBeer, S.; Vonck, J.; Steuber, J.; Fritz, G.: Conformational coupling of redox-driven Na⁺-translocation in Vibrio cholerae NADH:quinone oxidoreductase. Nature Structural & Molecular Biology 30 (11), pp. 1686 - 1694 (2023)

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Ornelas, P.; Bausewein, T.; Martin, J.; Morgner, N.; Nussberger, S.; Kühlbrandt, W.: Two conformations of the Tom20 preprotein receptor in the TOM holo complex. Proceedings of the National Academy of Sciences of the United States of America 120 (34), e2301447120 (2023)

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Fuss, M. F.; Wieferig, J.-P.; Corey, R. A.; Hellmich, Y.; Tascón, I.; Sousa, J. S.; Stansfeld, P. J.; Vonck, J.; Hänelt, I.: Cyclic di-AMP traps proton-coupled K⁺ transporters of the KUP family in an inward-occluded conformation. Nature Communications 14, 3683 (2023)

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Klusch, N.; Dreimann, M.; Senkler, J.; Rugen, N.; Kühlbrandt, W.; Braun, H.-P.: Cryo-EM structure of the respiratory I + III₂ supercomplex from Arabidopsis thaliana at 2 Å resolution. Nature Plants 9, pp. 142 - 156 (2023)

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Wieferig, J.-P.; Kühlbrandt, W.: Analysis of the conformational heterogeneity of the Rieske iron–sulfur protein in complex III₂ by cryo-EM. IUCrJ 10 (1), pp. 27 - 37 (2023)

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2022

Journal Article

Laube, E.; Meier-Credo, J.; Langer, J. D.; Kühlbrandt, W.: Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum. Science Advances 8 (47), eadc9952 (2022)

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Schiller, J.; Laube, E.; Wittig, I.; Kühlbrandt, W.; Vonck, J.; Zickermann, V.: Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling. Science Advances 8 (46), eadd3855 (2022)

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Kühlbrandt, W.: Concluding remarks: Challenges and future developments in biological electron cryo-microscopy. Faraday Discussions 240, pp. 323 - 335 (2022)

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Vitt, S.; Prinz, S.; Eisinger, M. L.; Ermler, U.; Buckel, W.: Purification and structural characterization of the Na⁺-translocating ferredoxin: NAD⁺ reductase (Rnf) complex of Clostridium tetanomorphum. Nature Communications 13, 6315 (2022)

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Lee, Y.; Haapanen, O.; Altmeyer, A.; Kühlbrandt, W.; Sharma, V.; Zickermann, V.: Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations. Nature Communications 13 (1), 6091 (2022)

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Journal Article

Meier-Credo, J.; Preiss, L.; Wüllenweber, I.; Resemann, A.; Nordmann, C.; Zabret, J.; Suckau, D.; Michel, H.; Nowacyk, M. M.; Meier, T. et al.; Langer, J. D.: Top-Down Identification and Sequence Analysis of Small Membrane Proteins Using MALDI-MS/MS. Journal of the American Society for Mass Spectrometry 33 (7), pp. 1293 - 1302 (2022)

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Journal Article

Heinz, V.; Jäckel, W.; Kaltwasser, S.; Cutugno, L.; Bedrunka, P.; Graf, A.; Reder, A.; Michalik, S.; Dhople, V. M.; Madei, M. G. et al.; Conway, M.; Lechner, M.; Riedel, K.; Bange, G.; Boyd, A.; Völker, U.; Lewis, R. J.; Marles-Wright, J.; Ziegler, C.; Pané-Farré, J.: The Vibrio vulnificus stressosome is an oxygen-sensor involved in regulating iron metabolism. Communications Biology 5, 622 (2022)

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Journal Article

Miksys, A.; Fu, L.; Madej, M. G.; Guerreiro, D. N.; Kaltwasser, S.; Conway, M.; Ejder, S.; Bruckmann, A.; Marles-Wright, J.; Lewis, R. J. et al.; O'Byrne, C.; Pané-Farré, J.; Ziegler, C.: Molecular insights into intra-complex signal transmission during stressosome activation. Communications Biology 5, 621 (2022)

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Journal Article

Aziz, I.; Kaltwasser, S.; Kayastha, K.; Khera, R.; Vonck, J.; Ermler, U.: The molybdenum storage protein forms and deposits distinct polynuclear tungsten oxygen aggregates. Journal of Inorganic Biochemistry 234, 111904 (2022)

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Journal Article

Lee, Y.; Wiriyasermkul, P.; Kongpracha, P.; Moriyama, S.; Mills, D. J.; Kühlbrandt, W.; Nagamori, S.: Ca²⁺-mediated higher-order assembly of heterodimers in amino acid transport system b^0,+ biogenesis and cystinuria. Nature Communications 13, 2708 (2022)

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Journal Article

Yadav, S.; Centola, M.; Glaesmann, M.; Pogoryelov, D.; Ladig, R.; Heilemann, M.; Rai, L. C.; Yildiz, Ö.; Schleiff, E.: Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium. Nature Communications 13 (1), 1690 (2022)

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Journal Article

Kühlbrandt, W.: Forty years in cryoEM of membrane proteins. Microscopy 71 (Supplement 1), pp. i30 - i50 (2022)

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Journal Article

Hards, K.; Cheung, C.-Y.; Waller, N.; Adolph, C.; Keighley, L.; Tee, Z. S.; Harold, L. K.; Menorca, A.; Bujaroski, R. S.; Buckley, B. J. et al.; Tyndall, J. D.A.; McNeil, M. B.; Rhee, K. Y.; Opel-Reading, H. K.; Krause, K.; Preiss, L.; Langer, J. D.; Meier, T.; Hasenoehrl, E. J.; Berney, M.; Kelso, M. J.; Cook, G. M.: An amiloride derivative is active against the F₁F_o-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology 5 (1), 166 (2022)

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Journal Article

Tyagi, A.; Ahmed, T.; Jian, S.; Bajaj, S.; Ong, S. T.; Goay, S. S. M.; Zhao, Y.; Vorobyov, I.; Tian, C.; Chandy, K. G. et al.; Bhushan, S.: Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug. Proceedings of the National Academy of Sciences of the United States of America 119 (5), e2113536119 (2022)

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2021

Journal Article

Ellinghaus, T. L.; Marcellino, T.; Srinivasan, V.; Lill, R.; Kühlbrandt, W.: Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Science Advances 7 (52), eabk2392 (2021)

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Journal Article

Centola, M.; van Pee, K.; Betz, H.; Yildiz, Ö.: Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases. Nature Communications 12 (1), 6982 (2021)

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Journal Article

Parey, K.; Lasham, J.; Mills, D. J.; Djurabekova, A.; Haapanen, O.; Yoga, E. G.; Xie, H.; Kühlbrandt, W.; Sharma, V.; Vonck, J. et al.; Zickermann, V.: High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism. Science Advances 7 (46), eabj3221 (2021)

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Journal Article

Heit, S.; Geurts, M. M. G.; Murphy, B. J.; Corey, R. A.; Mills, D. J.; Kühlbrandt, W.; Bublitz, M.: Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state. Science Advances 7 (46), eabj5255 (2021)

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Journal Article

Chicano, T. M.; Dietrich, L.; de Almeida, N. M.; Akram, M.; Hartmann, E.; Leidreiter, F.; Leopoldus, D.; Mueller, M.; Sanchez, R. M.; Nuijten, G. H. L. et al.; Reimann, J.; Seifert, K.-A.; Schlichting, I.; van Niftrik, L.; Jetten, M. S. M.; Dietl, A.; Kartal, B.; Parey, K.; Barends, T. R. M.: Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex. Nature Microbiology 6 (9), pp. 1129 - 1139 (2021)

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Journal Article

Feyh, R.; Waeber, N. B.; Prinz, S.; Giammarinaro, P. I.; Bange, G.; Hochberg, G.; Hartmann, R. K.; Altegoer, F.: Structure and mechanistic features of the prokaryotic minimal RNase P. eLife 10, e70160 (2021)

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Journal Article

Klusch, N.; Senkler, J.; Yildiz, Ö.; Kühlbrandt, W.; Braun, H.-P.: A ferredoxin bridge connects the two arms of plant mitochondrial complex I. The Plant Cell 33 (6), pp. 2072 - 2091 (2021)

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Journal Article

Floris, D.; Kühlbrandt, W.: Molecular landscape of etioplast inner membranes in higher plants. Nature Plants 7 (4), pp. 514 - 523 (2021)

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Journal Article

D'Imprima, E.; Kühlbrandt, W.: Current limitations to high-resolution structure determination by single-particle cryoEM. Quarterly Reviews of Biophysics 54, e4 (2021)

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Journal Article

Wieferig, J.-P.; Mills, D. J.; Kühlbrandt, W.: Devitrification reduces beam-induced movement in cryo-EM. IUCrJ 8 (Pt 2), pp. 186 - 194 (2021)

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Journal Article

Riedel, R.; Frese, N.; Yang, F.; Wortmann, M.; Dalpke, R.; Rhinow, D.; Hampp, N.; Gölzhäuser, A.: Fusion of purple membranes triggered by immobilization on carbon nanomembranes. Beilstein Journal of Nanotechnology 12, pp. 93 - 101 (2021)

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Journal Article

Cunha, E. S.; Chen, X.; Sanz-Gaitero, M.; Mills, D. J.; Luecke, H.: Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution. Nature Communications 12 (1), 230 (2021)

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Journal Article

Mills, D. J.: Setting up and operating a cryo-EM laboratory. Quarterly Reviews of Biophysics 54, e2 (2021)

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2020

Journal Article

Ebenhoch, R.; Prinz, S.; Kaltwasser, S.; Mills, D. J.; Meinecke, R.; Rübbelke, M.; Reinert, D.; Bauer, M.; Weixler, L.; Zeeb, M. et al.; Vonck, J.; Nar, H.: A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proceedings of the National Academy of Sciences of the United States of America 117 (50), pp. 31838 - 31849 (2020)

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Journal Article

Oda, K.; Lee, Y.; Wiriyasermkul, P.; Tanaka, Y.; Takemoto, M.; Yamashita, K.; Nagamori, S.; Nishizawa, T.; Nureki, O.: Consensus mutagenesis approach improves the thermal stability of system x_c- transporter, xCT, and enables cryo-EM analyses. Protein Science 29, pp. 2398 - 2407 (2020)

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Journal Article

Yadav, S.; Centola, M.; Yildiz, Ö.; Pogoryelov, D.; Rai, L. C.; Schleiff, E.: Purification and Preliminary X-Ray Crystallographic Analysis of the Peptidyl-Prolyl cis-trans Isomerase Alr5059 from Anabaena sp. PCC 7120. Crystallography Reports 65 (7), pp. 1226 - 1230 (2020)

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Journal Article

Galemou Yoga, E.; Parey, K.; Djurabekova, A.; Haapanen, O.; Siegmund, K.; Zwicker, K.; Sharma, V.; Zickermann, V.; Angerer, H.: Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I. Nature Communications 11, 6008 (2020)

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Journal Article

Januliene, D.; Moeller, A.: Cryo-EM of ABC transporters: an ice-cold solution to everything? FEBS Letters 594, pp. 3776 - 3789 (2020)

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Journal Article

Ngo, G.; Centola, M.; Krasnoselska, G.; Pogoryelov, D.; Yildiz, Ö.; Schleiff, E.: LptC from Anabaena sp. PCC 7120: Expression, purification and crystallization. Protein Expression and Purification 175, 105689 (2020)

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Journal Article

Chowdhury, N. P.; Alberti, L.; Linder, M.; Müller, V.: Exploring Bacterial Microcompartments in the Acetogenic Bacterium Acetobacterium woodii. Frontiers in Microbiology 11, 593467 (2020)

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Journal Article

Gewering, T.; Möller, A.: Neue Möglichkeiten für die Strukturbestimmung von Membranproteinen. Biospektrum 26 (6), pp. 615 - 617 (2020)

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Journal Article

Shvarev, D.: Kryo-EM-Einzelpartikelanalyse eines Membrantransporters in Liposomen. Biospektrum 26, p. 650 - 650 (2020)

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Journal Article

Bayer, N. J.; Januliene, D.; Zocher, G.; Stehle, T.; Möller, A.; Blaum, B. S.: Structure of Merkel cell polyomavirus capsid and interaction with its glycosaminoglycan attachment receptor. Journal of Virology 94 (20), e01664-19 (2020)

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Journal Article

Wu, D.; Grund, T. N.; Welsch, S.; Mills, D.; Michel, M.; Safarian, S.; Michel, H.: Structural basis for amino acid exchange by a human heteromeric amino acid transporter. Proceedings of the National Academy of Sciences of the United States of America 117 (35), 202008111, pp. 21281 - 21287 (2020)

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Journal Article

Scherr, J.; Tang, Z.; Küllmer, M.; Balser, S.; Scholz, A. S.; Winter, A.; Parey, K.; Rittner, A.; Grininger, M.; Zickermann, V. et al.; Rhinow, D.; Terfort, A.; Turchanin, A.: Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy. ACS Nano 14 (8), pp. 9972 - 9978 (2020)

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Journal Article

Parey, K. K.; Wirth, C.; Vonck, J.; Zickermann, V.: Respiratory complex I - structure, mechanism and evolution. Current Opinion in Structural Biology 63 (2020)

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Journal Article

Rhinow, D.; Hampp, N.: Electron beam-induced electrostatic charging causes spectral changes of an insulating electrochromic material. Applied Physics Letters 117 (8), 083701 (2020)

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Journal Article

Sanchez, R. M.; Zhang, Y.; Chen, W.; Dietrich, L.; Kudryashev, M.: Subnanometer-resolution structure determination in situ by hybrid subtomogram averaging - single particle cryo-EM. Nature Communications 11, 3709 (2020)

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Journal Article

Dasbach, M.; Pyschik, M.; Lehmann, V.; Parey, K.; Rhinow, D.; Reinhardt, H. M.; Hampp, N. A.: Assembling Carbon Nanotube Architectures. ACS Nano 14 (7), pp. 8181 - 8190 (2020)

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Journal Article

Shvarev, D.: Kryo-EM-Einzelpartikelanalyse eines Membrantransporters in Liposomen. Biospektrum 26 (6), p. 650 - 650 (2020)

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Journal Article

Neuhaus, A.; Selvaraj, M.; Salzer, R.; Langer, J. D.; Kruse, K.; Kirchner, L.; Sanders, K.; Daum, B.; Averhoff, B.; Gold, V.: Cryo-electron microscopy reveals two distinct type IV pili assembled by the same bacterium. Nature Communications 11, 2231 (2020)

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Journal Article

Bausewein, T.; Naveed, H.; Liang, J.; Nussberger, S.: The structure of the TOM core complex in the mitochondrial outer membrane. Biological Chemistry 401 (6-7), pp. 687 - 697 (2020)

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Journal Article

Vitt, S.; Prinz, S.; Hellwig, N.; Morgner, N.; Ermler, U.; Buckel, W.: Molecular and Low-Resolution Structural Characterization of the Na+-Translocating Glutaconyl-CoA Decarboxylase From Clostridium symbiosum. Frontiers in Microbiology 11, 480 (2020)

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Journal Article

Vögele, M.; Bhaskara, R.; Mulvihill, E.; van Pee, K.; Yildiz, Ö.; Kühlbrandt, W.; Müller, D. J.; Hummer, G.: Reply to Desikan et al.: Micelle formation among various mechanisms of toxin pore formation. Proceedings of the National Academy of Sciences of the United States of America 117 (10), pp. 5109 - 5110 (2020)

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Journal Article

Tascón, I.; Sousa, J. S.; Corey, R. A.; Mills, D. J.; Griwatz, D.; Aumüller, N.; Mikusevic, V.; Stansfeld, P. J.; Vonck, J.; Hänelt, I.: Structural basis of proton-coupled potassium transport in the KUP family. Nature Communications 11, 626 (2020)

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Journal Article

Joppe, M.; D'Imprima, E.; Salustros, N.; Paithankar, K. S.; Vonck, J.; Grininger, M.; Kühlbrandt, W.: The resolution revolution in cryoEM requires high-quality sample preparation: a rapid pipeline to a high-resolution map of yeast fatty acid synthase. IUCrJ 7 (Pt 2), pp. 220 - 227 (2020)

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Journal Article

Fischer, M.; Joppe, M.; Mulinacci, B.; Vollrath, R.; Konstantinidis, K.; Kötter, P.; Ciccarelli, L.; Vonck, J.; Oesterhelt, D.; Grininger, M.: Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS). Scientific Reports 10 (1), 895 (2020)

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Warnau, J.; Wöhlert, D.; Okazaki, K.-I.; Yildiz, Ö.; Gamiz-Hernandez, A. P.; Kaila, V. R. I.; Kühlbrandt, W.; Hummer, G.: Ion Binding and Selectivity of the Na⁺/H⁺ Antiporter MjNhaP1 from Experiment and Simulation. The Journal of Physical Chemistry B 124 (2), pp. 336 - 344 (2020)

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Journal Article

Gewering, T.: Klassifizierung von Antikörpern zur Behandlung von COVID-19. Biospektrum 26 (7), p. 750 (2020)

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2019

Journal Article

Brünle, S.; Eisinger, M. L.; Poppe, J.; Mills, D. J.; Langer, J. D.; Vonck, J.; Ermler, U.: Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism. Proceedings of the National Academy of Sciences of the United States of America 52 (116), pp. 26497 - 26504 (2019)

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Journal Article

Parey, K.; Haapanen, O.; Sharma, V.; Köfeler, H.; Züllig, T.; Prinz, S.; Siegmund, K.; Wittig, I.; Mills, D.; Vonck, J. et al.; Kühlbrandt, W.; Zickermann, V.: High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease. Science Advances 5 (12), p. eaax9484 (2019)

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Journal Article

Pfeil-Gardiner, O.; Mills, D. J.; Vonck, J.; Kühlbrandt, W.: A comparative study of single-particle cryo-EM with liquid-nitrogen and liquid-helium cooling. IUCrJ 6, pp. 1099 - 1105 (2019)

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Journal Article

Ruesink, H.; Reimer, L.; Gregersen, E.; Möller, A.; Betzer, C.; Jensen, P. H.: Stabilization of α-synuclein oligomers using formaldehyde. PLoS One 14 (10), e0216764 (2019)

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Safarian, S.; Hahn, A.; Mills, D.; Radloff, M.; Eisinger, M. L.; Nikolaev, A.; Meier-Credo, J.; Melin, F.; Miyoshi, H.; Gennis, R.B. et al.; Sakamoto, J.; Langer, J. D.; Hellwig, P.; Kühlbrandt, W.; Michel, H.: Active site rearrangement and structural divergence in prokaryotic respiratory oxidases. Science 366 (6461), pp. 100 - 104 (2019)

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Hofmann, S.; Januliene, D.; Mehdipour, A. R.; Thomas, C.; Stefan, E.; Brüchert, S.; Kuhn, B. T.; Geertsma, E. R.; Hummer, G.; Tampé, R. et al.; Möller, A.: Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature 571 (7766), pp. 580 - 583 (2019)

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Faelber, K.; Dietrich, L.; Noel, J. K.; Wollweber, F.; Pfitzner, A.-K.; Mühleip, A.; Sánchez, R.; Kudryashev, M.; Chiaruttini, N.; Lilie, H. et al.; Schlegel, J.; Rosenbaum, E.; Hessenberger, M.; Matthaeus, C.; Kunz, S.; von der Malsburg, A.; Noè, F.; Roux, A.; van der Laan, M.; Kühlbrandt, W.; Daumke, O.: Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature 571 (7765), pp. 429 - 433 (2019)

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Timcenko, M.; Lyons, J. A.; Januliene, D.; Ulstrup, J. J.; Dieudonné, T.; Montigny, C.; Ash, M.-R.; Karlsen, J. L.; Boesen, T.; Kühlbrandt, W. et al.; Lenoir, G.; Möller, A.; Nissen, P.: Structure and autoregulation of a P4-ATPase lipid flippase. Nature 571 (7765), pp. 366 - 370 (2019)

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Vögele, M.; Bhaskara, R.; Mulvihill, E.; van Pee, K.; Yildiz, Ö.; Kühlbrandt, W.; Müller, D. J.; Hummer, G.: Membrane perforation by the pore-forming toxin pneumolysin. Proceedings of the National Academy of Sciences of the United States of America 116 (27), pp. 13352 - 13357 (2019)

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Bausewein, T.; Nussberger, S.; Kühlbrandt, W.: Cryo-EM structure of Neurospora crassa respiratory complex IV. IUCrJ 6 (4), pp. 773 - 780 (2019)

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Scherr, J.; Neuhaus, A.; Parey, K.; Klusch, N.; Murphy, B. J.; Zickermann, V.; Kühlbrandt, W.; Terfort, A.; Rhinow, D.: Noncovalent Functionalization of Carbon Substrates with Hydrogels Improves Structural Analysis of Vitrified Proteins by Electron Cryo-Microscopy. ACS Nano 13 (6), pp. 7185 - 7190 (2019)

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Murphy, B. J.; Klusch, N.; Langer, J. D.; Mills, D.; Yildiz, Ö.; Kühlbrandt, W.: Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F₁-F_o coupling. Science 364 (6446), eaaw9128, p. 1155 (2019)

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Yilmaz, I.; Yildiz, Ö.; Korkmaz, F.: Structural properties of an engineered outer membrane protein G mutant, OmpG-16SL, investigated with infrared spectroscopy. Journal of Biomolecular Structure and Dynamics 37 (2019)

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Akram, M.; Dietl, A.; Mersdorf, U.; Prinz, S.; Maalcke, W. J.; Keltjens, J. T.; Ferousi, C.; de Almeida, N. M.; Reimann, J.; Kartal, B. et al.; Jetten, M. S. M.; Parey, K.; Barends, T.: A 192-heme electron transfer network in the hydrazine dehydrogenase complex. Science Advances 5 (4), eaav4310 (2019)

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Okazaki, K.-i.; Wöhlert, D.; Warnau, J.; Jung, H.; Yildiz, Ö.; Kühlbrandt, W.; Hummer, G.: Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting. Nature Communications 10, 1742 (2019)

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D'Imprima, E.; Floris, D.; Joppe, M.; Sánchez, R.; Grinninger, M.; Kühlbrandt, W.: Protein denaturation at the air-water interface and how to prevent it. eLife 8, e42747 (2019)

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Reich, S.; Kaiser, P.; Mafi, M.; Schmalz, H.; Rhinow, D.; Freitag, R.; Greiner, A.: High-Temperature Spray-Dried Polymer/Bacteria Microparticles for Electrospinning of Composite Nonwovens. Macromolecular Bioscience 19 (3), 1800356 (2019)

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Blum, T.; Hahn, A.; Meier, T.; Davies, K. M.; Kühlbrandt, W.: Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows. Proceedings of the National Academy of Sciences of the United States of America 116 (10), pp. 4250 - 4255 (2019)

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Leone, V.; Waclawska, I.; Kossmann, K.; Koshy, C.; Sharma, M.; Prisner, T. F.; Ziegler, C.; Endeward, B.; Forrest, L. R.: Interpretation of spectroscopic data using molecular simulations for the secondary active transporter BetP. Journal of General Physiology 151 (3), pp. 381 - 394 (2019)

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Kühlbrandt, W.: Structure and Mechanisms of F-Type ATP Synthases. Annual Review of Biochemistry 88, pp. 515 - 549 (2019)

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Werner Kühlbrandt: Structural Biology – Department Publications

Journal Article (487)