Werner Kühlbrandt: Structural Biology – Department Publications
Journal Article (479)
2025
Journal Article
Cryo-EM structure of the NDH-PSI-LHCI supercomplex from Spinacia oleracea. Nature Structural & Molecular Biology (2025)
Journal Article
12 (1) (2025)
Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM. IUCrJ 2024
Journal Article
14, 25192 (2024)
Nanoelectrospray based synthesis of large, transportable membranes with integrated membrane proteins. Scientific Reports
Journal Article
385 (6713), pp. 1086 - 1090 (2024)
In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells. Science
Journal Article
32 (7), pp. 979 - 988.e4 (2024)
Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism. Structure
Journal Article
31, pp. 683 - 698.e7 (2024)
A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chemical Biology
Journal Article
121 (14), e2315568121 (2024)
Structural and mechanistic basis of the central energy-converting methyltransferase complex of methanogenesis. PNAS
Journal Article
128 (10), pp. 2304 - 2316 (2024)
Role of Protonation States in the Stability of Molecular Dynamics Simulations of High-Resolution Membrane Protein Structures. The Journal of Physical Chemistry B
Journal Article
80, pp. 159 - 173 (2024)
Using cryo-EM to understand the assembly pathway of respiratory complex I. Acta Crystallographica Section D: Structural Biology
Journal Article
19 (2), pp. 226 - 236 (2024)
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower. Nature Nanotechnology
Journal Article
12, RP90174 (2024)
Tracing the substrate translocation mechanism in P-glycoprotein. eLife
Journal Article
29 (1), pp. 64 - 71 (2024)
Promotion of oxidative phosphorylation by complex I-anchored carbonic anhydrases? Trends in Plant Science
Journal Article
1866 (1), 149512 (2024)
Assessment of amino acid charge states based on cryo-electron microscopy and molecular dynamics simulations of respiratory complex I. Biochimica et Biophysica Acta (BBA) - Bioenergetics 2023
Journal Article
30 (11), pp. 1686 - 1694 (2023)
Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase. Nature Structural & Molecular Biology
Journal Article
120 (34), e2301447120 (2023)
Two conformations of the Tom20 preprotein receptor in the TOM holo complex. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
14, 3683 (2023)
Cyclic di-AMP traps proton-coupled K+ transporters of the KUP family in an inward-occluded conformation. Nature Communications
Journal Article
9, pp. 142 - 156 (2023)
Cryo-EM structure of the respiratory I + III2 supercomplex from Arabidopsis thaliana at 2 Å resolution. Nature Plants
Journal Article
10 (1), pp. 27 - 37 (2023)
Analysis of the conformational heterogeneity of the Rieske iron–sulfur protein in complex III2 by cryo-EM. IUCrJ 2022
Journal Article
8 (47), eadc9952 (2022)
Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum. Science Advances
Journal Article
8 (46), eadd3855 (2022)
Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling. Science Advances
Journal Article
240, pp. 323 - 335 (2022)
Concluding remarks: Challenges and future developments in biological electron cryo-microscopy. Faraday Discussions
Journal Article
13, 6315 (2022)
Purification and structural characterization of the Na+-translocating ferredoxin: NAD+ reductase (Rnf) complex of Clostridium tetanomorphum. Nature Communications
Journal Article
13 (1), 6091 (2022)
Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations. Nature Communications
Journal Article
33 (7), pp. 1293 - 1302 (2022)
Top-Down Identification and Sequence Analysis of Small Membrane Proteins Using MALDI-MS/MS. Journal of the American Society for Mass Spectrometry
Journal Article
5, 622 (2022)
The Vibrio vulnificus stressosome is an oxygen-sensor involved in regulating iron metabolism. Communications Biology
Journal Article
5, 621 (2022)
Molecular insights into intra-complex signal transmission during stressosome activation. Communications Biology
Journal Article
234, 111904 (2022)
The molybdenum storage protein forms and deposits distinct polynuclear tungsten oxygen aggregates. Journal of Inorganic Biochemistry
Journal Article
13, 2708 (2022)
Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria. Nature Communications
Journal Article
13 (1), 1690 (2022)
Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium. Nature Communications
Journal Article
71 (Supplement 1), pp. i30 - i50 (2022)
Forty years in cryoEM of membrane proteins. Microscopy
Journal Article
5 (1), 166 (2022)
An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology
Journal Article
119 (5), e2113536119 (2022)
Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug. Proceedings of the National Academy of Sciences of the United States of America 2021
Journal Article
7 (52), eabk2392 (2021)
Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Science Advances
Journal Article
12 (1), 6982 (2021)
Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases. Nature Communications
Journal Article
7 (46), eabj3221 (2021)
High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism. Science Advances
Journal Article
7 (46), eabj5255 (2021)
Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state. Science Advances
Journal Article
6 (9), pp. 1129 - 1139 (2021)
Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex. Nature Microbiology
Journal Article
10, e70160 (2021)
Structure and mechanistic features of the prokaryotic minimal RNase P. eLife
Journal Article
33 (6), pp. 2072 - 2091 (2021)
A ferredoxin bridge connects the two arms of plant mitochondrial complex I. The Plant Cell
Journal Article
7 (4), pp. 514 - 523 (2021)
Molecular landscape of etioplast inner membranes in higher plants. Nature Plants
Journal Article
54, e4 (2021)
Current limitations to high-resolution structure determination by single-particle cryoEM. Quarterly Reviews of Biophysics
Journal Article
8 (Pt 2), pp. 186 - 194 (2021)
Devitrification reduces beam-induced movement in cryo-EM. IUCrJ
Journal Article
12, pp. 93 - 101 (2021)
Fusion of purple membranes triggered by immobilization on carbon nanomembranes. Beilstein Journal of Nanotechnology
Journal Article
12 (1), 230 (2021)
Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution. Nature Communications
Journal Article
54, e2 (2021)
Setting up and operating a cryo-EM laboratory. Quarterly Reviews of Biophysics 2020
Journal Article
117 (50), pp. 31838 - 31849 (2020)
A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
29, pp. 2398 - 2407 (2020)
Consensus mutagenesis approach improves the thermal stability of system xc- transporter, xCT, and enables cryo-EM analyses. Protein Science
Journal Article
65 (7), pp. 1226 - 1230 (2020)
Purification and Preliminary X-Ray Crystallographic Analysis of the Peptidyl-Prolyl cis-trans Isomerase Alr5059 from Anabaena sp. PCC 7120. Crystallography Reports
Journal Article
11, 6008 (2020)
Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I. Nature Communications
Journal Article
594, pp. 3776 - 3789 (2020)
Cryo-EM of ABC transporters: an ice-cold solution to everything? FEBS Letters
Journal Article
175, 105689 (2020)
LptC from Anabaena sp. PCC 7120: Expression, purification and crystallization. Protein Expression and Purification
Journal Article
11, 593467 (2020)
Exploring Bacterial Microcompartments in the Acetogenic Bacterium Acetobacterium woodii. Frontiers in Microbiology
Journal Article
26 (6), pp. 615 - 617 (2020)
Neue Möglichkeiten für die Strukturbestimmung von Membranproteinen. Biospektrum
Journal Article
26, p. 650 - 650 (2020)
Kryo-EM-Einzelpartikelanalyse eines Membrantransporters in Liposomen. Biospektrum
Journal Article
94 (20), e01664-19 (2020)
Structure of Merkel cell polyomavirus capsid and interaction with its glycosaminoglycan attachment receptor. Journal of Virology
Journal Article
117 (35), 202008111, pp. 21281 - 21287 (2020)
Structural basis for amino acid exchange by a human heteromeric amino acid transporter. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
14 (8), pp. 9972 - 9978 (2020)
Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy. ACS Nano
Journal Article
63 (2020)
Respiratory complex I - structure, mechanism and evolution. Current Opinion in Structural Biology
Journal Article
117 (8), 083701 (2020)
Electron beam-induced electrostatic charging causes spectral changes of an insulating electrochromic material. Applied Physics Letters
Journal Article
11, 3709 (2020)
Subnanometer-resolution structure determination in situ by hybrid subtomogram averaging - single particle cryo-EM. Nature Communications
Journal Article
14 (7), pp. 8181 - 8190 (2020)
Assembling Carbon Nanotube Architectures. ACS Nano
Journal Article
26 (6), p. 650 - 650 (2020)
Kryo-EM-Einzelpartikelanalyse eines Membrantransporters in Liposomen. Biospektrum
Journal Article
11, 2231 (2020)
Cryo-electron microscopy reveals two distinct type IV pili assembled by the same bacterium. Nature Communications
Journal Article
401 (6-7), pp. 687 - 697 (2020)
The structure of the TOM core complex in the mitochondrial outer membrane. Biological Chemistry
Journal Article
11, 480 (2020)
Molecular and Low-Resolution Structural Characterization of the Na+-Translocating Glutaconyl-CoA Decarboxylase From Clostridium symbiosum. Frontiers in Microbiology
Journal Article
117 (10), pp. 5109 - 5110 (2020)
Reply to Desikan et al.: Micelle formation among various mechanisms of toxin pore formation. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
11, 626 (2020)
Structural basis of proton-coupled potassium transport in the KUP family. Nature Communications
Journal Article
7 (Pt 2), pp. 220 - 227 (2020)
The resolution revolution in cryoEM requires high-quality sample preparation: a rapid pipeline to a high-resolution map of yeast fatty acid synthase. IUCrJ
Journal Article
10 (1), 895 (2020)
Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS). Scientific Reports
Journal Article
124 (2), pp. 336 - 344 (2020)
Ion Binding and Selectivity of the Na+/H+ Antiporter MjNhaP1 from Experiment and Simulation. The Journal of Physical Chemistry B
Journal Article
26 (7), p. 750 (2020)
Klassifizierung von Antikörpern zur Behandlung von COVID-19. Biospektrum 2019
Journal Article
52 (116), pp. 26497 - 26504 (2019)
Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
5 (12), p. eaax9484 (2019)
High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease. Science Advances
Journal Article
6, pp. 1099 - 1105 (2019)
A comparative study of single-particle cryo-EM with liquid-nitrogen and liquid-helium cooling. IUCrJ
Journal Article
14 (10), e0216764 (2019)
Stabilization of α-synuclein oligomers using formaldehyde. PLoS One
Journal Article
366 (6461), pp. 100 - 104 (2019)
Active site rearrangement and structural divergence in prokaryotic respiratory oxidases. Science
Journal Article
571 (7766), pp. 580 - 583 (2019)
Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature
Journal Article
571 (7765), pp. 429 - 433 (2019)
Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature
Journal Article
571 (7765), pp. 366 - 370 (2019)
Structure and autoregulation of a P4-ATPase lipid flippase. Nature
Journal Article
116 (27), pp. 13352 - 13357 (2019)
Membrane perforation by the pore-forming toxin pneumolysin. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
6 (4), pp. 773 - 780 (2019)
Cryo-EM structure of Neurospora crassa respiratory complex IV. IUCrJ
Journal Article
13 (6), pp. 7185 - 7190 (2019)
Noncovalent Functionalization of Carbon Substrates with Hydrogels Improves Structural Analysis of Vitrified Proteins by Electron Cryo-Microscopy. ACS Nano
Journal Article
364 (6446), eaaw9128, p. 1155 (2019)
Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F1-Fo coupling. Science
Journal Article
37 (2019)
Structural properties of an engineered outer membrane protein G mutant, OmpG-16SL, investigated with infrared spectroscopy. Journal of Biomolecular Structure and Dynamics
Journal Article
5 (4), eaav4310 (2019)
A 192-heme electron transfer network in the hydrazine dehydrogenase complex. Science Advances
Journal Article
10, 1742 (2019)
Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting. Nature Communications
Journal Article
8, e42747 (2019)
Protein denaturation at the air-water interface and how to prevent it. eLife
Journal Article
19 (3), 1800356 (2019)
High-Temperature Spray-Dried Polymer/Bacteria Microparticles for Electrospinning of Composite Nonwovens. Macromolecular Bioscience
Journal Article
116 (10), pp. 4250 - 4255 (2019)
Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
151 (3), pp. 381 - 394 (2019)
Interpretation of spectroscopic data using molecular simulations for the secondary active transporter BetP. Journal of General Physiology
Journal Article
88, pp. 515 - 549 (2019)
Structure and Mechanisms of F-Type ATP Synthases. Annual Review of Biochemistry
Journal Article
26 (2), pp. 87 - 89 (2019)
Respiratory supercomplexes III2IV2 come into focus. Nature Structural and Molecular Biology 2018
Journal Article
7, e39213 (2018)
Cryo-EM structure of respiratory complex I at work. eLife
Journal Article
67 (5), pp. 266 - 273 (2018)
Bayesian inference of rotor ring stoichiometry from electron microscopy images of archaeal ATP synthase. Microscopy
Journal Article
9, 1728 (2018)
Structural basis for energy transduction by respiratory alternative complex III. Nature Communications
Journal Article
9, 329 (2018)
ATP Synthase Diseases of Mitochondrial Genetic Origin. Frontiers in Physiology
Journal Article
115 (12), pp. 3024 - 3029 (2018)
Conserved in situ arrangement of complex I and III2 in mitochondrial respiratory chain supercomplexes of mammals, yeast, and plants. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
115 (13), pp. E2906 - E2907 (2018)
Structure of the catalytic F1 head of the F1-Fo ATP synthase from Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
592 (3), pp. 343 - 355 (2018)
Reversible Optical Control of F1F0-ATP Synthase Using Photoswitchable Inhibitors. FEBS Letters