Investigator: Martin Beck Project Period: 2023–2028
Objective: Martin Beck studies very large macromolecular complexes in cells. To investigate their structure, dynamics, and function in their native environment, he uses cryo-electron tomography, biochemical methods, live cell imaging, and computational modeling in a holistic approach. In frame of the ERC project, he will investigate how mechanical properties of nuclear pores interplay with their transport function. His research generally addresses the function of nuclear pore complexes, which consist of about 1000 proteins and form huge channels in the nuclear membrane of eukaryotic cells. By regulating the exchange of material between nucleoplasm and cytosol, they protect the genomic integritymore