Investigator: Eugene Kim
Project Period: 2023–2028
Objective:Cells can fit approximately two metres of human DNA into a few micrometres. To package DNA into such a tiny space, it is complexed with proteins into chromatin which, in turn, folds into chromosomes. This condensation also helps regulate access to genetic information according to cell needs. Funded by the European Research Council, the LoopSMC project aims to investigate the mechanism by which DNA is folded. Researchers will focus on the process of loop extrusion and elucidate the role of specific proteins. The work will provide both structural and dynamic insight into the function and kinetics of loop extrusion in cellular processes. This is essential to understanding the fundamental packaging structure of the genome and its biological function.
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