Structural Proteomics

Structural Proteomics

Department of Molecular Sociology (MS)

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Protein complexes are a fundamental organisational unit of the proteome. They are functionally fine-tuned towards context-specific needs, i.e. with respect to cell types or across individuals. We are interested in how protein complexes are assembled and how variations in their stoichiometry alter their function. We use methods such as cross-linking mass spectrometry, thermal protein profiling, quantitative proteomics and data mining to study the dynamics of protein complex architecture.

Selected Publications

Romanov N, Kuhn M, Aebersold R, Ori A, Beck M, Bork P.
Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals.
Cell. 2019 May 16;177(5):1308-1318.e10. doi: 10.1016/j.cell.2019.03.015.
Becher I, Andres-Pons A, Romanov N, Stein F, Schramm M, Baudin F, Helm D, Kurzawa N, Mateus A, Mackmull MT, Typas A, Müller CW, Bork P, Beck M, Savitski MM.
Pervasive Protein Thermal Stability Variation during the Cell Cycle.
Cell. 2018 May 31;173(6):1495-1507.e18. doi: 10.1016/j.cell.2018.03.053.
Mackmull MT, Klaus B, Heinze I, Chokkalingam M, Beyer A, Russell RB, Ori A, Beck M.
Landscape of nuclear transport receptor cargo specificity.
Mol Syst Biol. 2017 Dec 18;13(12):962. doi: 10.15252/msb.20177608.
Ori A, Iskar M, Buczak K, Kastritis P, Parca L, Andres-Pons A, Singer S, Bork P, Beck M.
Spatiotemporal variation of mammalian protein complex stoichiometries.
Genome Biol. 2016 Mar 14;17:47. doi: 10.1186/s13059-016-0912-5.
Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M.
Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats.
Cell Syst. 2015 Sep 23;1(3):224-37. doi: 10.1016/j.cels.2015.08.012.
Ori A, Banterle N, Iskar M, Andres-Pons A, Escher C, Khanh Bui H, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M.
Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.
Mol Syst Biol. 2013;9:648. doi: 10.1038/msb.2013.4.
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