Werner Kühlbrandt Publications

2024

Journal Article

Periasamy, A.; Ornelas, P.; Bausewein, T.; Mitchell, N.; Zhao, J.; Quinn, L. M.; Kuehlbrandt, W.; Gulbis, J. M.: Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM. IUCrJ (2024)

MPG.PuRe

DOI

Full

Journal Article

Dietrich, L.; Agip, A.-N. A.; Kunz, C.; Schwarz, A.; Kühlbrandt, W.: In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells. Science 385 (6713), pp. 1086 - 1090 (2024)

MPG.PuRe

DOI

Journal Article

Schneider, S.; Kühlbrandt, W.; Yildiz, Ö.: Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism. Structure 32 (7), pp. 979 - 988.e4 (2024)

MPG.PuRe

DOI

Full

2023

Journal Article

Ornelas, P.; Bausewein, T.; Martin, J.; Morgner, N.; Nussberger, S.; Kühlbrandt, W.: Two conformations of the Tom20 preprotein receptor in the TOM holo complex. Proceedings of the National Academy of Sciences of the United States of America 120 (34), e2301447120 (2023)

MPG.PuRe

DOI

Full

Journal Article

Klusch, N.; Dreimann, M.; Senkler, J.; Rugen, N.; Kühlbrandt, W.; Braun, H.-P.: Cryo-EM structure of the respiratory I + III₂ supercomplex from Arabidopsis thaliana at 2 Å resolution. Nature Plants 9, pp. 142 - 156 (2023)

MPG.PuRe

DOI

Full

Journal Article

Wieferig, J.-P.; Kühlbrandt, W.: Analysis of the conformational heterogeneity of the Rieske iron–sulfur protein in complex III₂ by cryo-EM. IUCrJ 10 (1), pp. 27 - 37 (2023)

MPG.PuRe

DOI

Full

2022

Journal Article

Laube, E.; Meier-Credo, J.; Langer, J. D.; Kühlbrandt, W.: Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum. Science Advances 8 (47), eadc9952 (2022)

MPG.PuRe

DOI

Full

Journal Article

Schiller, J.; Laube, E.; Wittig, I.; Kühlbrandt, W.; Vonck, J.; Zickermann, V.: Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling. Science Advances 8 (46), eadd3855 (2022)

MPG.PuRe

DOI

Full

Journal Article

Kühlbrandt, W.: Concluding remarks: Challenges and future developments in biological electron cryo-microscopy. Faraday Discussions 240, pp. 323 - 335 (2022)

MPG.PuRe

DOI

Full

Journal Article

Lee, Y.; Haapanen, O.; Altmeyer, A.; Kühlbrandt, W.; Sharma, V.; Zickermann, V.: Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations. Nature Communications 13 (1), 6091 (2022)

MPG.PuRe

DOI

Full

Journal Article

Lee, Y.; Wiriyasermkul, P.; Kongpracha, P.; Moriyama, S.; Mills, D. J.; Kühlbrandt, W.; Nagamori, S.: Ca²⁺-mediated higher-order assembly of heterodimers in amino acid transport system b^0,+ biogenesis and cystinuria. Nature Communications 13, 2708 (2022)

MPG.PuRe

DOI

Journal Article

Kühlbrandt, W.: Forty years in cryoEM of membrane proteins. Microscopy 71 (Supplement 1), pp. i30 - i50 (2022)

MPG.PuRe

DOI

2021

Journal Article

Ellinghaus, T. L.; Marcellino, T.; Srinivasan, V.; Lill, R.; Kühlbrandt, W.: Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Science Advances 7 (52), eabk2392 (2021)

MPG.PuRe

DOI

Journal Article

Parey, K.; Lasham, J.; Mills, D. J.; Djurabekova, A.; Haapanen, O.; Yoga, E. G.; Xie, H.; Kühlbrandt, W.; Sharma, V.; Vonck, J. et al.; Zickermann, V.: High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism. Science Advances 7 (46), eabj3221 (2021)

MPG.PuRe

DOI

Journal Article

Heit, S.; Geurts, M. M. G.; Murphy, B. J.; Corey, R. A.; Mills, D. J.; Kühlbrandt, W.; Bublitz, M.: Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state. Science Advances 7 (46), eabj5255 (2021)

MPG.PuRe

DOI

Journal Article

Klusch, N.; Senkler, J.; Yildiz, Ö.; Kühlbrandt, W.; Braun, H.-P.: A ferredoxin bridge connects the two arms of plant mitochondrial complex I. The Plant Cell 33 (6), pp. 2072 - 2091 (2021)

MPG.PuRe

DOI

Journal Article

Floris, D.; Kühlbrandt, W.: Molecular landscape of etioplast inner membranes in higher plants. Nature Plants 7 (4), pp. 514 - 523 (2021)

MPG.PuRe

DOI

Journal Article

D'Imprima, E.; Kühlbrandt, W.: Current limitations to high-resolution structure determination by single-particle cryoEM. Quarterly Reviews of Biophysics 54, e4 (2021)

MPG.PuRe

DOI

Journal Article

Wieferig, J.-P.; Mills, D. J.; Kühlbrandt, W.: Devitrification reduces beam-induced movement in cryo-EM. IUCrJ 8 (Pt 2), pp. 186 - 194 (2021)

MPG.PuRe

DOI

2020

Journal Article

Vögele, M.; Bhaskara, R.; Mulvihill, E.; van Pee, K.; Yildiz, Ö.; Kühlbrandt, W.; Müller, D. J.; Hummer, G.: Reply to Desikan et al.: Micelle formation among various mechanisms of toxin pore formation. Proceedings of the National Academy of Sciences of the United States of America 117 (10), pp. 5109 - 5110 (2020)

MPG.PuRe

DOI

Journal Article

Joppe, M.; D'Imprima, E.; Salustros, N.; Paithankar, K. S.; Vonck, J.; Grininger, M.; Kühlbrandt, W.: The resolution revolution in cryoEM requires high-quality sample preparation: a rapid pipeline to a high-resolution map of yeast fatty acid synthase. IUCrJ 7 (Pt 2), pp. 220 - 227 (2020)

MPG.PuRe

DOI

Journal Article

Warnau, J.; Wöhlert, D.; Okazaki, K.-I.; Yildiz, Ö.; Gamiz-Hernandez, A. P.; Kaila, V. R. I.; Kühlbrandt, W.; Hummer, G.: Ion Binding and Selectivity of the Na⁺/H⁺ Antiporter MjNhaP1 from Experiment and Simulation. The Journal of Physical Chemistry B 124 (2), pp. 336 - 344 (2020)

MPG.PuRe

DOI

2019

Journal Article

Parey, K.; Haapanen, O.; Sharma, V.; Köfeler, H.; Züllig, T.; Prinz, S.; Siegmund, K.; Wittig, I.; Mills, D.; Vonck, J. et al.; Kühlbrandt, W.; Zickermann, V.: High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease. Science Advances 5 (12), p. eaax9484 (2019)

MPG.PuRe

DOI

Journal Article

Pfeil-Gardiner, O.; Mills, D. J.; Vonck, J.; Kühlbrandt, W.: A comparative study of single-particle cryo-EM with liquid-nitrogen and liquid-helium cooling. IUCrJ 6, pp. 1099 - 1105 (2019)

MPG.PuRe

DOI

Journal Article

Safarian, S.; Hahn, A.; Mills, D.; Radloff, M.; Eisinger, M. L.; Nikolaev, A.; Meier-Credo, J.; Melin, F.; Miyoshi, H.; Gennis, R.B. et al.; Sakamoto, J.; Langer, J. D.; Hellwig, P.; Kühlbrandt, W.; Michel, H.: Active site rearrangement and structural divergence in prokaryotic respiratory oxidases. Science 366 (6461), pp. 100 - 104 (2019)

MPG.PuRe

DOI

Journal Article

Faelber, K.; Dietrich, L.; Noel, J. K.; Wollweber, F.; Pfitzner, A.-K.; Mühleip, A.; Sánchez, R.; Kudryashev, M.; Chiaruttini, N.; Lilie, H. et al.; Schlegel, J.; Rosenbaum, E.; Hessenberger, M.; Matthaeus, C.; Kunz, S.; von der Malsburg, A.; Noè, F.; Roux, A.; van der Laan, M.; Kühlbrandt, W.; Daumke, O.: Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature 571 (7765), pp. 429 - 433 (2019)

MPG.PuRe

DOI

Journal Article

Timcenko, M.; Lyons, J. A.; Januliene, D.; Ulstrup, J. J.; Dieudonné, T.; Montigny, C.; Ash, M.-R.; Karlsen, J. L.; Boesen, T.; Kühlbrandt, W. et al.; Lenoir, G.; Möller, A.; Nissen, P.: Structure and autoregulation of a P4-ATPase lipid flippase. Nature 571 (7765), pp. 366 - 370 (2019)

MPG.PuRe

DOI

Journal Article

Vögele, M.; Bhaskara, R.; Mulvihill, E.; van Pee, K.; Yildiz, Ö.; Kühlbrandt, W.; Müller, D. J.; Hummer, G.: Membrane perforation by the pore-forming toxin pneumolysin. Proceedings of the National Academy of Sciences of the United States of America 116 (27), pp. 13352 - 13357 (2019)

MPG.PuRe

DOI

Journal Article

Bausewein, T.; Nussberger, S.; Kühlbrandt, W.: Cryo-EM structure of Neurospora crassa respiratory complex IV. IUCrJ 6 (4), pp. 773 - 780 (2019)

MPG.PuRe

DOI

Journal Article

Scherr, J.; Neuhaus, A.; Parey, K.; Klusch, N.; Murphy, B. J.; Zickermann, V.; Kühlbrandt, W.; Terfort, A.; Rhinow, D.: Noncovalent Functionalization of Carbon Substrates with Hydrogels Improves Structural Analysis of Vitrified Proteins by Electron Cryo-Microscopy. ACS Nano 13 (6), pp. 7185 - 7190 (2019)

MPG.PuRe

DOI

Journal Article

Murphy, B. J.; Klusch, N.; Langer, J. D.; Mills, D.; Yildiz, Ö.; Kühlbrandt, W.: Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F₁-F_o coupling. Science 364 (6446), eaaw9128, p. 1155 (2019)

MPG.PuRe

DOI

Journal Article

Okazaki, K.-i.; Wöhlert, D.; Warnau, J.; Jung, H.; Yildiz, Ö.; Kühlbrandt, W.; Hummer, G.: Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting. Nature Communications 10, 1742 (2019)

MPG.PuRe

DOI

Journal Article

D'Imprima, E.; Floris, D.; Joppe, M.; Sánchez, R.; Grinninger, M.; Kühlbrandt, W.: Protein denaturation at the air-water interface and how to prevent it. eLife 8, e42747 (2019)

MPG.PuRe

DOI

Journal Article

Blum, T.; Hahn, A.; Meier, T.; Davies, K. M.; Kühlbrandt, W.: Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows. Proceedings of the National Academy of Sciences of the United States of America 116 (10), pp. 4250 - 4255 (2019)

MPG.PuRe

DOI

Journal Article

Kühlbrandt, W.: Structure and Mechanisms of F-Type ATP Synthases. Annual Review of Biochemistry 88, pp. 515 - 549 (2019)

MPG.PuRe

DOI

2018

Journal Article

Parey, K.; Brandt, U.; Xie, H.; Mills, D. J.; Siegmund, K.; Vonck, J.; Kühlbrandt, W.; Zickermann, V.: Cryo-EM structure of respiratory complex I at work. eLife 7, e39213 (2018)

MPG.PuRe

DOI

Journal Article

Sousa, J. S.; Calisto, F.; Langer, J. D.; Mills, D. J.; Refojo, P. N.; Teixeira, M.; Kühlbrandt, W.; Vonck, J.; Pereira, M. M.: Structural basis for energy transduction by respiratory alternative complex III. Nature Communications 9, 1728 (2018)

MPG.PuRe

DOI

Journal Article

Davies, K. M.; Blum, T. B.; Kühlbrandt, W.: Conserved in situ arrangement of complex I and III₂ in mitochondrial respiratory chain supercomplexes of mammals, yeast, and plants. Proceedings of the National Academy of Sciences of the United States of America 115 (12), pp. 3024 - 3029 (2018)

MPG.PuRe

DOI

Journal Article

Davies, K. M.; Kühlbrandt, W.: Structure of the catalytic F₁ head of the F₁-F_o ATP synthase from Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America 115 (13), pp. E2906 - E2907 (2018)

MPG.PuRe

DOI

Journal Article

Hahn, A.; Vonck, J.; Mills, D. J.; Meier, T.; Kühlbrandt, W.: Structure, mechanism, and regulation of the chloroplast ATP synthase. Science 360 (6389), pp. 1 - 10 (2018)

MPG.PuRe

DOI

2017

Journal Article

D'Imprima, E.; Salzer, R.; Bhaskara, R. M.; Sánchez, R.; Rose, I.; Kirchner, L.; Hummer, G.; Kühlbrandt, W.; Vonck, J.; Averhoff, B.: Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus. eLife 6, 10.7554/eLife.30483 (2017)

MPG.PuRe

DOI

Journal Article

Klusch, N.; Murphy, B. J.; Mills, D.; Yildiy, Ö.; Kühlbrandt, W.: Structural basis of proton translocation and force generation in mitochondrial ATP synthase. eLife 6, e33274 (2017)

MPG.PuRe

DOI

Journal Article

Bausewein, T.; Mills, D. J.; Langer, J. D.; Nitschke, B.; Nussberger, S.; Kühlbrandt, W.: Cryo-EM Structure of the TOM Core Complex from Neurospora crassa. Cell 170 (4), pp. 693 - 700 (2017)

MPG.PuRe

DOI

Journal Article

Brandt, T.; Mourier, A.; Tain, L. S.; Partridge, L.; Larsson, N.-G.; Kühlbrandt, W.: Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila. eLife 6, e24662 (2017)

MPG.PuRe

DOI

Journal Article

Daum, B.; Vonck, J.; Bellack, A.; Chaudhury, P.; Reichelt, R.; Albers, S.-V.; Rachel, R.; Kühlbrandt, W.: Structure and in situ organisation of the Pyrococcus furiosus archaellum machinery. eLife 6, e27470 (2017)

MPG.PuRe

DOI

Journal Article

van Pee, K.; Neuhaus, A.; D'Imprima, E.; Mills, D. J.; Kühlbrandt, W.; Yildiz, Ö.: CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin. eLife 6, e23644 (2017)

MPG.PuRe

DOI

Journal Article

Mühleip, A. W.; Dewar, C. E.; Schnaufer, A.; Kühlbrandt, W.; Davies, K. M.: In situ structure of trypanosomal ATP synthase dimer reveals a unique arrangement of catalytic subunits. Proceedings of the National Academy of Sciences of the United States of America 114 (5), pp. 992 - 997 (2017)

MPG.PuRe

DOI

Journal Article

Retel, J. S.; Nieuwkoop, A. J.; Hiller, M.; Higman, V. A.; Barbet-Massin, E.; Stanek, J.; Andreas, L. B.; Franks, W. T.; van Rossum, B.-J.; Vinothkumar, K. R. et al.; Handel, L.; de Palma, G. G.; Bardiaux, B.; Pintacuda, G.; Emsley, L.; Kühlbrandt, W.; Oschkinat, H.: Structure of outer membrane protein G in lipid bilayers. Nature Communications 8, 2073, p. 1 (2017)

MPG.PuRe

DOI

Journal Article

Scherr, J.; Parey, K.; Klusch, N.; Murphy, B. J.; Balser, S.; Neuhaus, A.; Zickermann, V.; Kühlbrandt, W.; Terfort, A.; Rhinow, D.: Self-Perforated Hydrogel Nanomembranes Facilitate Structural Analysis of Proteins by Electron Cryo-Microscopy. ACS Nano 11 (6), pp. 6467 - 6473 (2017)

MPG.PuRe

DOI

Journal Article

Schulz, S.; Wilkes, M.; Mills, D. J.; Kühlbrandt, W.; Meier, T.: Molecular architecture of the N‐type ATPase rotor ring from Burkholderia pseudomallei. EMBO Reports 18 (6), pp. 1 - 10 (2017)

MPG.PuRe

DOI

Journal Article

Wilkes, M.; Madej, G. M.; Kreuter, L.; Rhinow, D.; Heinz, V.; De Sanctis, S.; Ruppel, S.; Richter, R. M.; Joos, F.; Grieben, M. et al.; Pike, A. C. W.; Huiskonen, J. T.; Carpenter, E. P.; Kühlbrandt, W.; Witzgall, R.: Molecular insights into lipid-assisted Ca²⁺ regulation of the TRP channel Polycystin-2. Nature Structural and Molecular Biology 24 (2), pp. 123 - 130 (2017)

MPG.PuRe

DOI

2016

Journal Article

Călinescu, O.; Linder, M.; Wöhlert, D.; Yildiz, Ö.; Kühlbrandt, W.; Fendler, K.: Electrogenic Cation Binding in the Electroneutral Na⁺/H⁺ Antiporter of Pyrococcus abyssi. The Journal of Biological Chemistry 291 (52), pp. 26786 - 26793 (2016)

MPG.PuRe

DOI

Journal Article

Sousa, J. S.; Mills, D. J.; Vonck, J.; Kühlbrandt, W.: Functional asymmetry and electron flow in the bovine respirasome. eLife 5, e21290 (2016)

MPG.PuRe

DOI

Journal Article

Brandt, T.; Cavellini, L.; Kühlbrandt, W.; Cohen, M. M.: A mitofusin-dependent docking ring complex triggers mitochondrial fusion in vitro. eLife 5, e14618 (2016)

MPG.PuRe

DOI

Journal Article

D'Imprima, E.; Mills, D. J.; Parey, K.; Brandt, U.; Kühlbrandt, W.; Zickermann, V.; Vonck, J.: Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1857 (12), pp. 1935 - 1942 (2016)

MPG.PuRe

DOI

Journal Article

Daum, B.; Auerswald, A.; Gruber, T.; Hause, G.; Balbach, J.; Kühlbrandt, W.; Meister, A.: Supramolecular organization of the human N-BAR domain in shaping the sarcolemma membrane. Journal of Structural Biology 194 (3), pp. 375 - 382 (2016)

MPG.PuRe

DOI

Journal Article

Hahn, A.; Parey, K.; Bublitz, M.; Mills, D. J.; Zickermann, V.; Vonck, J.; Kühlbrandt, W.; Meier, T.: Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology. Molecular Cell 63, pp. 1 - 12 (2016)

MPG.PuRe

DOI

Journal Article

Kühlbrandt, W.: Three in a row - how sodium ions cross the channel. The EMBO Journal 35 (8), pp. 793 - 795 (2016)

MPG.PuRe

DOI

Journal Article

Kühlbrandt, W.; Davies, K. M.: Rotary ATPases: A New Twist to an Ancient Machine. Trends in biochemical sciences 41 (1), pp. 106 - 116 (2016)

MPG.PuRe

DOI

Journal Article

Mühleip, A. W.; Joos, F.; Wigge, C.; Frangakis, A. S.; Kühlbrandt, W.; Davies, K. M.: Helical arrays of U-shaped ATP synthase dimers form tubular cristae in ciliate mitochondria. Proceedings of the National Academy of Sciences of the United States of America 113 (30), pp. 8442 - 8447 (2016)

MPG.PuRe

DOI

Journal Article

Subramaniam, S.; Kühlbrandt, W.; Henderson, R.: CryoEM at IUCrJ: a new era. International Union of Crystallography Journal (IUCrJ) 3 (1), pp. 3 - 7 (2016)

MPG.PuRe

DOI

2015

Journal Article

Wöhlert, D.; Grötzinger, M. J.; Kühlbrandt, W.; Yildiz, Ö.: Mechanism of Na⁺-dependent citrate transport from the structure of an asymmetrical CitS dimer. eLife 4, e09375 (2015)

MPG.PuRe

DOI

Journal Article

Kühlbrandt, W.: Structure and function of mitochondrial membrane protein complexes. BMC Biology 13 (89), pp. 1 - 11 (2015)

MPG.PuRe

DOI

Journal Article

Walter, A.; Steltenkamp, S.; Schmitz, S.; Holik, P.; Pakanavicius, E.; Sachser, R.; Huth, M.; Rhinow, D.; Kühlbrandt, W.: Towards an optimum design for electrostatic phase plates. Ultramicroscopy 153 (June), pp. 22 - 31 (2015)

MPG.PuRe

DOI

Journal Article

Gold, V. A. M.; Salzer, R.; Averhoff, B.; Kühlbrandt, W.: Structure of a type IV pilus machinery in the open and closed state. eLife 4, e07380 (2015)

MPG.PuRe

DOI

Journal Article

Allegretti, M.; Klusch, N.; Mills, D. J.; Vonck, J.; Kühlbrandt, W.; Davies, K. M.: Horizontal membrane-intrinsic α-helices in the stator a-subunit of an F-type ATP synthase. Nature 521, pp. 237 - 240 (2015)

MPG.PuRe

DOI

Journal Article

Jiko, C.; Davies, K. M.; Shinzawa-Itoh, K.; Tani, K.; Maeda, S.; Mills, D. J.; Tsukihara, T.; Fujiyoshi, Y.; Kühlbrandt, W.; Gerle, C.: Bovine F₁F₀ ATP synthase monomers bend the lipid bilayer in 2D membrane crystals. eLife 4, e06119 (2015)

MPG.PuRe

DOI

Journal Article

Bohnert, M.; Zerbes, R. M.; Davies, K. M.; Mühleip, A. W.; Rampelt, H.; Horvath, S. E.; Boenke, T.; Kram, A.; Perschil, I.; Veenhuis, M. et al.; Kühlbrandt, W.; van der Klei, I. J.; Pfanner, N.; van der Laan, M.: Central Role of Mic10 in the Mitochondrial Contact Site and Cristae Organizing System. Cell Metabolism 21 (5), pp. 747 - 755 (2015)

MPG.PuRe

DOI

Journal Article

Kukat, C.; Davies, K. M.; Wurm, C. A.; Spåhr, H.; Bonekamp, N. A.; Kühl, I.; Joos, F.; Polosa, P. L.; Park, C. B.; Posse, V. et al.; Falkenberg, M.; Jakobs, S.; Kühlbrandt, W.; Larsson, N.-G.: Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid. Proceedings of the National Academy of Sciences of the United States of America 112 (36), pp. 11288 - 11293 (2015)

MPG.PuRe

DOI

Journal Article

Müller, M.; Bamann, C.; Bamberg, E.; Kühlbrandt, W.: Light-Induced Helix Movements in Channelrhodopsin-2. J. Mol. Biol. 427 (2), pp. 341 - 349 (2015)

MPG.PuRe

DOI

Journal Article

Vrandecic, K.; Rätsep, M.; Wilk, L.; Rusevich, L.; Golub, M.; Reppert, M.; Irrgang, K.-D.; Kühlbrandt, W.; Pieper, J.: Protein Dynamics Tunes Excited State Positions in Light-Harvesting Complex II. The Journal of Physical Chemistry B 119 (10), pp. 3920 - 3930 (2015)

MPG.PuRe

DOI

2014

Journal Article

Paulino, C.; Wöhlert, D.; Kapotova, E.; Yildiz, Ö.; Kühlbrandt, W.: Structure and transport mechanism of the sodium/proton antiporter MjNhaP1. eLife 3, e03583 (2014)

MPG.PuRe

DOI

Journal Article

Wöhlert, D.; Kühlbrandt, W.; Yildiz, Ö.: Structure and substrate ion binding in the sodium/proton antiporter PaNhaP. eLife 3, e03579 (2014)

MPG.PuRe

DOI

Journal Article

Patwardhan, A.; Ashton, A.; Brandt, R.; Butcher, S.; Carzaniga, R.; Chiu, W.; Collison, L.; Doux, P.; Duke, E.; Ellisman, M. H. et al.; Franken, E.; Grünewald, K.; Heriche, J.-K.; Koster, A.; Kühlbrandt, W.; Lagerstedt, I.; Larabell, C.; Lawson, C. L.; Saibil, H. R.; Sanz-García, E.; Subramaniam, S.; Verkade, P.; Swedlow, J. R.; Kleywegt, G. J.: A 3D cellular context for the macromolecular world. Nature Structural and Molecular Biology 21 (10), pp. 841 - 845 (2014)

MPG.PuRe

DOI

Journal Article

Kühlbrandt, W.: Microscopy: Cryo-EM enters a new era. eLife 3, e03678 (2014)

MPG.PuRe

DOI

Journal Article

Gold, V. A. M.; Ieva, R.; Walter, A.; Pfanner, N.; van der Laan, M.; Kühlbrandt, W.: Visualizing active membrane protein complexes by electron cryotomography. Nature Communications 5, 4129 (2014)

MPG.PuRe

DOI

Journal Article

Călinescu, O.; Paulino, C.; Kühlbrandt, W.; Fendler, K.: Keeping It Simple, Transport Mechanism and pH Regulation in Na⁺/H⁺. The Journal of Biological Chemistry 289, pp. 13168 - 13176 (2014)

MPG.PuRe

DOI

Journal Article

Kühlbrandt, W.: The Resolution Revolution. Science 343 (6178), pp. 1443 - 1444 (2014)

MPG.PuRe

DOI

Journal Article

Allegretti, M.; Mills, D. J.; McMullen, G.; Kühlbrandt, W.; Vonck, J.: Atomic model of the F₄₂₀-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector. eLife 3, e01963 (2014)

MPG.PuRe

DOI

Journal Article

Paulino, C.; Kühlbrandt, W.: pH- and sodium-induced changes in a sodium/proton antiporter. eLife 3, e01412 (2014)

MPG.PuRe

DOI

Journal Article

Daum, B.; Quax, T. E. F.; Sachse, M.; Mills, D. J.; Reimann, J.; Yildiz, Ö.; Häder, S.; Saveanu, C.; Forterre, P.; Albers, S.-V. et al.; Kühlbrandt, W.; Prangishvili, D.: Self-assembly of the general membrane-remodeling protein PVAP into sevenfold virus-associated pyramids. Proceedings of the National Academy of Sciences of the United States of America 111 (10), pp. 3829 - 3834 (2014)

MPG.PuRe

DOI

Journal Article

Davies, K. M.; Daum, B.; Gold, V. A. M.; Mühleip, A. W.; Brandt, T.; Blum, T.; Mills, D. J.; Kühlbrandt, W.: Visualization of ATP Synthase Dimers in Mitochondria by Electron Cryo-tomography. Journal of Visualized Experiments (91 doi: 10.3791/51228), e51228 (2014)

MPG.PuRe

DOI

Journal Article

Köster, S.; van Pee, K.; Hudel, M.; Leustik, M.; Rhinow, D.; Kühlbrandt, W.; Chakraborty, T.: Crystal structure of listeriolysin O reveals molecular details of oligomerization and pore formation. Nature Communications 5, 3690 (2014)

MPG.PuRe

DOI

Journal Article

Mourier, A.; Ruzzenente, B.; Brandt, T.; Kühlbrandt, W.; Larsson, N.-G.: Loss of LRPPRC causes ATP synthase deficiency. Human Molecular Genetics 23 (10), pp. 2580 - 2592 (2014)

MPG.PuRe

DOI

2013

Journal Article

Quemin, E. R. J.; Lucas, S.; Daum, B.; Quax, T. E. F.; Kühlbrandt, W.; Forterre, P.; Albers, S.-V.; Prangishvili, D.; Krupovic, M.: First insights into the entry process of hyperthermophilic archaeal viruses. Journal of Virology 87 (24), pp. 13379 - 13385 (2013)

MPG.PuRe

DOI

Full

Journal Article

Kalayil, S.; Schulze, S.; Kühlbrandt, W.: Arginine oscillation explains Na⁺ independence in the substrate/product antiporter CaiT. Proceedings of the National Academy of Sciences of the United States of America 110 (43), pp. 17296 - 17301 (2013)

MPG.PuRe

DOI

Journal Article

Daum, B.; Walter, A.; Horst, A.; Osiewacz, H. D.; Kühlbrandt, W.: Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria. Proceedings of the National Academy of Sciences of the United States of America 110 (38), pp. 15301 - 15306 (2013)

MPG.PuRe

DOI

Journal Article

Wilk, L.; Grunwald, M.; Liao, P.-N.; Walla, P. J.; Kühlbrandt, W.: Direct interaction of the major light-harvesting complex II and PsbS in nonphotochemical quenching. Proceedings of the National Academy of Sciences of the United States of America 110 (14), pp. 5452 - 5456 (2013)

MPG.PuRe

DOI

2012

Journal Article

Davies, K. M.; Anselmi, C.; Wittig, I.; Faraldo-Gómez, J. D.; Kühlbrandt, W.: Structure of the yeast F₁F₀-ATP synthase dimer and its role in shaping the mitochondrial cristae. Proceedings of the National Academy of Sciences of the United States of America 109 (34), pp. 13602 - 13607 (2012)

MPG.PuRe

DOI

Journal Article

Althoff, T.; Davies, K. M.; Schulze, S.; Joos, F.; Kühlbrandt, W.: GRecon: A Method for the Lipid Reconstitution of Membrane Proteins. Angewandte Chemie, International Edition in English 51 (33), pp. 8343 - 8347 (2012)

MPG.PuRe

DOI

Journal Article

Walter, A.; Muzik, H.; Vieker, H.; Turchanin, A.; Beyer, A.; Gölzhäuser, A.; Lacher, M.; Steltenkamp, S.; Schmitz, S.; Holik, P. et al.; Kühlbrandt, W.; Rhinow, D.: Practical aspects of Boersch phase contrast electron microscopy of biological specimens. Ultramicroscopy 116, pp. 62 - 72 (2012)

MPG.PuRe

DOI

Journal Article

Hizlan, D.; Robson, A.; Whitehouse, S.; Gold, V. A.; Vonck, J.; Mills, D.; Kühlbrandt, W.; Collinson, I.: Structure of the SecY Complex Unlocked by a Preprotein Mimic. Cell Reports 1 (1), pp. 21 - 28 (2012)

MPG.PuRe

DOI

2011

Journal Article

Barton, B.; Rhinow, D.; Walter, A.; Schröder, R. R.; Benner, G.; Majorovits, E.; Matijevic, M.; Niebel, H.; Müller, H.; Haider, M. et al.; Lacher, M.; Schmitz, S.; Holik, P.; Kühlbrandt, W.: In-focus electron microscopy of frozen-hydrated biological samples with a Boersch phase plate. Ultramicroscopy 111 (12), pp. 1696 - 1705 (2011)

MPG.PuRe

DOI

Journal Article

Köster, S.; Pavkov-Keller, T.; Kühlbrandt, W.; Yildiz, Ö.: Structure of Human Na⁺/H⁺ Exchanger NHE₁ Regulatory Region in Complex with Calmodulin and Ca²⁺. The Journal of Biological Chemistry 286 (47), pp. 40954 - 40961 (2011)

MPG.PuRe

DOI

Journal Article

Müller, M.; Bamann, C.; Bamberg, E.; Kühlbrandt, W.: Projection Structure of Channelrhodopsin-2 at 6 Å Resolution by Electron Crystallography. Journal of Molecular Biology 414 (1), pp. 86 - 95 (2011)

MPG.PuRe

DOI

Journal Article

Wilk, L.; Strauss, M.; Rudolf, M.; Nicolaisen, K.; Flores, E.; Kühlbrandt, W.; Schleiff, E.: Outer membrane continuity and septosome formation between vegetative cells in the filaments of Anabaena sp. PCC 7120. Cellular Microbiology 13 (11), pp. 1744 - 1754 (2011)

MPG.PuRe

DOI

Journal Article

Rhinow, D.; Weber, N.-E.; Turchanin, A.; Gölzhäuser, A.; Kühlbrandt, W.: Single-walled carbon nanotubes and nanocrystalline graphene reduce beam-induced movements in high-resolution electron cryo-microscopy of ice-embedded biological samples. Applied Physics Letters 99 (3), 133701 (2011)

MPG.PuRe

DOI

Journal Article

Davies, K. M.; Strauss, M.; Daum, B.; Kief, J. H.; Osiewacz, H. D.; Rycovska, A.; Zickermann, V.; Kühlbrandt, W.: Macromolecular organization of ATP synthase and complex I in whole mitochondria. Proceedings of the National Academy of Sciences of the United States of America 108 (34), pp. 14121 - 14126 (2011)

MPG.PuRe

DOI

Journal Article

Sommer, M. S.; Daum, B.; Gross, L. E.; Weis, B. L. M.; Mirus, O.; Abram, L.; Maier, U.-G.; Kühlbrandt, W.; Schleiff, E.: Chloroplast Omp85 proteins change orientation during evolution. Proceedings of the National Academy of Sciences of the United States of America 108 (33), pp. 13841 - 13846 (2011)

MPG.PuRe

DOI

Werner Kühlbrandt Publications

Journal Article (225)