Werner Kühlbrandt Publications

Publications of Lucy R. Forrest

Journal Article (25)

2015
Journal Article
Fowler, P. W.; Orwick-Rydmark, M.; Radestock, S.; Solcan, N.; Dijkman, P. M.; Lyons, J. A.; Kwok, J.; Caffrey, M.; Watts, A.; Forrest, L. R. et al.; Newstead, S.: Gating Topology of the Proton-Coupled Oligopeptide Symporters. Structure 23 (2), pp. 290 - 301 (2015)
Journal Article
Schweikhard, E. S.; Burckhardt, B. C.; Joos, F.; Fenollar-Ferrer, C.; Forrest, L. R.; Kempson, S. A.; Ziegler, C.: Role of N-glycosylation in renal betaine transport. Biochemical Journal 470 (2), pp. 169 - 179 (2015)
2014
Journal Article
Fenollar-Ferrer, C.; Stockner, T.; Schwarz, T. C.; Pal, A.; Gotovina, J.; Hofmaier, T.; Jayaraman, K.; Adhikary, S.; Kudlacek, O.; Mehdipour, A. R. et al.; Tavoulari, S.; Rudnick, G.; Singh, S. K.; Konrat, R.; Sitte, H. H.; Forrest, L. R.: Structure and Regulatory Interactions of the Cytoplasmic Terminal Domains of Serotonin Transporter. Biochemistry 53 (33), pp. 5444 - 5460 (2014)
Journal Article
Perez, C.; Faust, B.; Mehdipour, A. R.; Francesconi, K. A.; Forrest, L. R.; Ziegler, C.: Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling. Nature Communications 5, 4231 (2014)
Journal Article
Stamm, M.; Staritzbichler, R.; Khafizov, K.; Forrest, L. R.: AlignMe-a membrane protein sequence alignment web server. Nucleic Acids Research 42 (W1), pp. W246 - W251 (2014)
Journal Article
Fenollar-Ferrer, C.; Patti, M.; Knöpfel, T.; Werner, A.; Forster, I. C.; Forrest, L. R.: Structural Fold and Binding Sites of the Human Na+-Phosphate Cotransporter NaPi-II. Biophysical Journal 106 (6), pp. 1268 - 1279 (2014)
2013
Journal Article
Yaffe, D.; Radestock, S.; Shuster, Y.; Forrest, L. R.; Schuldiner, S.: Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2. Proceedings of the National Academy of Sciences of the United States of America 110 (15), pp. E1332 - E1341 (2013)
Journal Article
Stamm, M.; Staritzbichler, R.; Khafizov, K.; Forrest, L. R.: Alignment of Helical Membrane Protein Sequences Using AlignMe. PLoS One 8 (3), e57731 (2013)
Journal Article
Forrest, L. R.: (Pseudo-)Symmetrical Transport. Science 339 (6118), pp. 339 - 401 (2013)
Journal Article
Silverstein, N.; Crisman, T. J.; Forrest, L. R.; Kanner, B. I.: Cysteine Scanning Mutagenesis of Transmembrane Helix 3 of a Brain Glutamate Transporter Reveals Two Conformationally Sensitive Positions. The Journal of Biological Chemistry 288 (2), pp. 964 - 973 (2013)
2012
Journal Article
Gradogna, A.; Fenollar-Ferrer, C.; Forrest, L. R.; Pusch, M.: Dissecting a regulatory calcium-binding site of CLC-K kidney chloride channels. Journal of General Physiology 140 (6), pp. 681 - 696 (2012)
Journal Article
Khafizov, K.; Perez, C.; Koshy, C.; Quick, M.; Fendler, K.; Ziegler, C.; Forrest, L. R.: Investigation of the sodium binding sites in the betaine transporter BetP. Proceedings of the National Academy of Sciences of the United States of America 109 (44), pp. E3035 - E3045 (2012)
Journal Article
Schushan, M.; Rimon, A.; Haliloglu, T.; Forrest, L. R.; Padan, E.; Ben-Tal, N.: A Model-Structure of a Periplasm-facing State of the NhaA Antiporter Suggests the Molecular Underpinnings of pH-induced Conformational Changes. The Journal of Biological Chemistry 287 (22), pp. 18249 - 18261 (2012)
2011
Journal Article
Perez, C.; Khafizov, K.; Forrest, L. R.; Krämer, R.; Ziegler, C.: The role of trimerization in the osmoregulated betaine transporter BetP. EMBO Reports 12 (8), pp. 804 - 810 (2011)
Journal Article
Radestock, S.; Forrest, L. R.: The Alternating-Access Mechanism of MFS Transporters Arises from Inverted-Topology Repeats. Journal of Molecular Biology 407 (5), pp. 698 - 715 (2011)
Journal Article
Staritzbichler, R.; Anselmi, C.; Forrest, L. R.; Faraldo-Gómez, J. D.: GRIFFIN: A Versatile Methodology for Optimization of Protein-Lipid Interfaces for Membrane Protein Simulations. Journal of Chemical Theory and Computation 7 (4), pp. 1167 - 1176 (2011)
Journal Article
Faraldo-Gómez, J. D.; Forrest, L. R.: Modeling and simulation of ion-coupled and ATP-driven membrane proteins. Current Opinion in Structural Biology 21 (2), pp. 173 - 179 (2011)
Journal Article
Tsai, C.-J.; Khafizov, K.; Hakulinen, J.; Forrest, L. R.; Krämer, R.; Kühlbrandt, W.; Ziegler, C.: Structural Asymmetry in a Trimeric Na+/Betaine Symporter, BetP, from Corynebacterium glutamicum. Journal of Molecular Biology 407 (3), pp. 368 - 381 (2011)
Journal Article
Forrest, L. R.; Krämer, R.; Ziegler, C.: The structural basis of secondary active transport mechanisms. Biochimica et Biophysica Acta, Bioenergetics 1807 (2), pp. 167 - 188 (2011)
Journal Article
Tavoulari, S.; Rizwan, A. N.; Forrest, L. R.; Rudnick, G.: Reconstructing a Chloride-binding Site in a Bacterial Neurotransmitter Transporter Homologue. The Journal of Biological Chemistry 286 (4), pp. 2834 - 2842 (2011)
2010
Journal Article
Khafizov, K.; Staritzbichler, R.; Stamm, M.; Forrest, L. R.: A Study of the Evolution of Inverted-Topology Repeats from LeuT-Fold Transporters Using AlignMe. Biochemistry 49 (50), pp. 10702 - 10713 (2010)
2009
Journal Article
Crisman, T. J.; Qu, S.; Kanner, B. I.; Forrest, L. R.: Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats. Proceedings of the National Academy of Sciences of the United States of America 106 (49), pp. 20752 - 20757 (2009)
Journal Article
Forrest, L. R.; Rudnick, G.: The Rocking Bundle: A Mechanism for Ion-Coupled Solute Flux by Symmetrical Transporters. Physiology 24 (6), pp. 377 - 386 (2009)
Journal Article
Tavoulari, S.; Forrest, L. R.; Rudnick, G.: Fluoxetine (Prozac) Binding to Serotonin Transporter Is Modulated by Chloride and Conformational Changes. The Journal of Neuroscience 29 (30), pp. 9635 - 9643 (2009)
2008
Journal Article
Trötschel, C.; Follmann, M.; Nettekoven, J. A.; Mohrbach, T.; Forrest, L. R.; Burkovski, A.; Marin, K.; Krämer, R.: Methionine Uptake in Corynebacterium glutamicum by MetQNI and by MetPS, a Novel Methionine and Alanine Importer of the NSS Neurotransmitter Transporter Family. Biochemistry 47 (48), pp. 12698 - 12709 (2008)

Conference Paper (1)

2011
Conference Paper
Khafizov, K.; Perez, C.; Tsai, C.-J.; Ziegler, C.; Forrest, L. R.: Computational and Experimental Studies of Substrate Binding, Conformational Change and Importance of the Trimeric State in the Glycine Betaine Transporter BetP. Biophysical Journal (Annual Meeting Abstracts) 100 (3, Supplement 1), p. 132a - 132a (2011)
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