Chromosome resolution

When cells enter mitosis, interphase chromatins experience dramatic reshaping into compressed, cylindrical shape of chromosomes, followed by efficient segregation to daughter cells. Such structural changes comprise a range of different biochemical processes, including longitudinal condensation of the chromosome axis, loss of cohesion, resolution of sister chromatids, and individualization of chromosomes into separate bodies. We are broadly interested in understanding how the molecular mechanisms underlying these individual processes are coordinated to resolve sister DNAs into separate bodies.