Ana J. García-Sáez Publications

2025

Journal Article

Majoul, A.; Garcia-Saez, A. J.: Dynamic regulation of cell death signaling. Current Opinion in Cell Biology 97, 102583 (2025)

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Hohorst, L.; Ros, U.; Garcia-Saez, A. J.: Mitochondrial dynamics and pore formation in regulated cell death pathways. Trends in Biochemical Sciences 50 (11), pp. 1001 - 1014 (2025)

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Zaghbani, S.; Faber, L.; Garcia Saez, A. J.: Convolutional Neural Network approach to classify mitochondrial morphologies. Computational Biology and Chemistry 118, 108477 (2025)

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King, L. E.; Faber, L.; García-Sáez, A. J.: Activator of apoptosis harakiri (HRK) localisation at mitochondria alters mitochondrial morphology independently of other BCL-2 proteins. The FEBS Journal (2025)

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Zaghbani, S.; Pranti, R. K.; Faber, L.; Garcia-Saez, A. J.: MitoSkel: AI tool for semantic segmentation and quantification of mitochondria from light microscopy images. Biomedical Signal Processing and Control 106, 107762 (2025)

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Garcia-Saez, A. J.; McBride, H.: Special Issue – Cell Biology of Mitochondria. Journal of Cell Science 138 (9), jcs264067 (2025)

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Ros, U.; Martinez-Osorio, V.; Valiente, P. A.; Abdelwahab, Y.; Gojkovic, M.; Shalaby, R.; Zanna, S.; Saggau, J.; Wachsmuth, L.; Nemade, H. N. et al.; Zoeller, J.; Lottermoser, H.; Chen, Y.-G.; Ibrahim, M.; Kelepouras, K.; Vasilikos, L.; Bedoya, P.; Espiritu, R. A.; Müller, S.; Altmannova, V.; Tieleman, D. P.; Weir, J.; Langer, J. D.; Adam, M.; Walczak, H.; Wong, W. W.-L.; Liccardi, G.; Mollenhauer, M.; Pasparakis, M.; Peltzer, N.; García-Sáez, A. J.: MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Molecular Cell 85 (8), pp. 1589 - 1605 (2025)

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Smarduch, S.; Moreno-Velasquez, S. D.; Ilic, D.; Dadsena, S.; Morant, R.; Ciprinidis, A.; Pereira, G.; Binder, M.; García-Sáez, A. J.; Acebrón, S. P.: A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA. The EMBO Journal 44 (7), pp. 2157 - 2182 (2025)

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Roeck, B. F.; Lotfipour Nasudivar, S.; Vorndran, M. R. H.; Schueller, L.; Yapici, F. I.; Rübsam, M.; von Karstedt, S.; Niessen, C. M.; Garcia-Saez, A. J.: Ferroptosis spreads to neighboring cells via plasma membrane contacts. Nature Communications 16, 2951 (2025)

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Pedrera, L.; Prieto Clemente, L.; Dahlhaus, A.; Lotfipour Nasudivar, S.; Tishina, S.; Olmo González, D.; Stroh, J.; Yapici, F. I.; Singh, R. P.; Grotehans, N. et al.; Langer, T.; García-Sáez, A. J.; von Karstedt, S.: Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death and Disease 16, 40 (2025)

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Etxebeste-Mitxeltorena, M.; Flores-Romero, H.; Ramos-Inza, S.; Masiá, E.; Nenchova, M.; Montesinos, J.; Martinez-Gonzalez, L.; Porras, G.; Orzáez, M.; Vicent, M. J. et al.; Gil, C.; Area-Gomez, E.; Garcia-Saez, A. J.; Martinez, A.: Modulation of Mitochondria-Endoplasmic Reticulum Contacts (MERCs) by Small Molecules as a New Strategy for Restoring Lipid Metabolism in an Amyotrophic Lateral Sclerosis Model. Journal of Medicinal Chemistry 68 (2), pp. 1179 - 1194 (2025)

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2024

Journal Article

Lotfipour Nasudivar, S.; Pedrera, L.; García-Sáez, A. J.: Iron-Induced Lipid Oxidation Alters Membrane Mechanics Favoring Permeabilization. Langmuir 40 (47), pp. 2561 - 2568 (2024)

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Schmitt, L.; Krings, K. S.; Wolsing, A.; Buque, X.; Zimmermann, M.; Flores-Romero, H.; Lenz, T.; Lechtenberg, I.; Peter, C.; Stork, B. et al.; Teusch, N.; Proksch, P.; Stühler, K.; García-Sáez, A. J.; Reichert, A. S.; Aspichueta, P.; Bhatia, S.; Wesselborg, S.: Targeting mitochondrial metabolism by the mitotoxin bromoxib in leukemia and lymphoma cells. Cell Communication and Signaling 22, 541 (2024)

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Berndt, C.; Alborzinia, H.; Amen, V. S.; Ayton, S.; Barayeu, U.; Bartelt, A.; Bayir, H.; Bebber, C. M.; Birsoy, K.; Böttcher, J. P. et al.; Brabletz, S.; Brabletz, T.; Brown, A. R.; Brüne, B.; Bulli, G.; Bruneau, A.; Chen, Q.; DeNicola, G. M.; Dick, T. P.; Distéfano, A.; Dixon, S. J.; Engler, J. B.; Esser-von Bieren, J.; Fedorova, M.; Friedmann Angeli, J. P.; Friese, M. A.; Fuhrmann, D. C.; García-Sáez, A. J.; Garbowicz, K.; Götz, M.; Gu, W.; Hammerich, L.; Hassannia, B.; Jiang, X.; Jeridi, A.; Kang, Y. P.; Kagan, V. E.; Konrad, D. B.; Kotschi, S.; Lei, P.; Le Tertre, M.; Lev, S.; Liang, D.; Linkermann, A.; Lohr, C.; Lorenz, S.; Luedde, T.; Methner, A.; Michalke, B.; Milton, A. V.; Min, J.; Mishima, E.; Müller, S.; Motohashi, H.; Muckenthaler, M. U.; Murakami, S.; Olzmann, J. A.; Pagnussat, G.; Pan, Z.; Papagiannakopoulos, T.; Pedrera Puentes, L.; Pratt, D. A.; Proneth, B.; Ramsauer, L.; Rodriguez, R.; Saito, Y.; Schmidt, F.; Schmitt, C.; Schulze, A.; Schwab, A.; Schwantes, A.; Soula, M.; Spitzlberger, B.; Stockwell, B. R.; Thewes, L.; Thorn-Seshold, O.; Toyokuni, S.; Tonnus, W.; Trumpp, A.; Vandenabeele, P.; Vanden Berghe, T.; Venkataramani, V.; Vogel, F. C. E.; von Karstedt, S.; Wang, F.; Westermann, F.; Wientjens, C.; Wilhelm, C.; Wölk, M.; Wu, K.; Yang, X.; Yu, F.; Zou, Y.; Conrad, M.: Ferroptosis in health and disease. Redox Biology: an official journal of the Society for Free Radical Biology and Medicine 75, 103211 (2024)

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Dai, E.; Chen, X.; Linkermann, A.; Jiang, X.; Kang, R.; Kagan, V. E.; Bayir, H.; Yang, W. S.; Garcia-Saez, A. J.; Ioannou, M. S. et al.; Janowitz, T.; Ran, Q.; Gu, W.; Gan, B.; Krysko, D. V.; Zhu, X.; Wang, J.; Krautwald, S.; Toyokuni, S.; Xie, Y.; Greten, F. R.; Yi, Q.; Schick, J.; Liu, J.; Gabrilovich, D. I.; Liu, J.; Zeh, H. J.; Zhang, D. D.; Yang, M.; Iovanna, J.; Kopf, M.; Adolph, T. E.; Chi, J.-T.; Li, C.; Ichijo, H.; Karin, M.; Sankaran, V. G.; Zou, W.; Galluzzi, L.; Bush, A. I.; Li, B.; Melino, G.; Baehrecke, E. H.; Lotze, M. T.; Klionsky, D. J.; Stockwell, B. R.; Kroemer, G.; Tang, D.: A guideline on the molecular ecosystem regulating ferroptosis. Nature Cell Biology 26 (9), pp. 1447 - 1457 (2024)

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Dadsena, S.; Cuevas Arenas, R.; Vieira, G.; Brodesser, S.; Melo, M. N.; García-Sáez, A. J.: Lipid unsaturation promotes BAX and BAK pore activity during apoptosis. Nature Communications 15, 4700 (2024)

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Froehlich, T.; Jenner, A.; Cavarischia-Rega, C.; Fagbadebo, F. O.; Lurz, Y.; Frecot, D. I.; Kaiser, P. D.; Nueske, S.; Scholz, A. M.; Schäffer, E. et al.; Garcia Saez, A. J.; Macek, B.; Rothbauer, U.: Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1. Life science alliance 7 (8), e202402608 (2024)

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García-Sáez, A. J.; Domingos, A. I.; Gutkind, J. S.; Mattoo, S.; Du, P.: Many paths lead to immunology. Cell 187 (9), pp. 2117 - 2119 (2024)

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Schmitt, L.; Lechtenberg, I.; Drießen, D.; Flores-Romero, H.; Skowron, M. A.; Sekeres, M.; Hoppe, J.; Krings, K. S.; Llewellyn, T. R.; Peter, C. et al.; Stork, B.; Qin, N.; Bhatia, S.; Nettersheim, D.; Fritz, G.; García-Sáez, A. J.; Müller, T. J. J.; Wesselborg, S.: Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2. Cell Death Discovery 10, 125 (2024)

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Freitas, F. P.; Alborzinia, H.; Dos Santos, A. F.; Nepachalovich, P.; Pedrera, L.; Zilka, O.; Inague, A.; Klein, C.; Aroua, N.; Kaushal, K. et al.; Kast, B.; Lorenz, S. M.; Kunz, V.; Nehring, H.; Xavier da Silva, T. N.; Chen, Z.; Atici, S.; Doll, S. G.; Schaefer, E. L.; Ekpo, I.; Schmitz, W.; Horling, A.; Imming, P.; Miyamoto, S.; Wehman, A. M.; Genaro-Mattos, T. C.; Mirnics, K.; Kumar, L.; Klein-Seetharaman, J.; Meierjohann, S.; Weigand, I.; Kroiss, M.; Bornkamm, G. W.; Gomes, F.; Netto, L. E. S.; Sathian, M. B.; Konrad, D. B.; Covey, D. F.; Michalke, B.; Bommert, K.; Bargou, R. C.; Garcia Saez, A. J.; Pratt, D. A.; Fedorova, M.; Trumpp, A.; Conrad, M.; Friedmann Angeli, J. P.: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature 626, pp. 401 - 410 (2024)

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2023

Journal Article

King, L. E.; Hohorst, L.; García-Sáez, A. J.: Expanding roles of BCL-2 proteins in apoptosis execution and beyond. Journal of Cell Science 136 (22), jcs260790 (2023)

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Czabotar, P. E.; Garcia-Saez, A. J.: Mechanisms of BCL-2 family proteins in mitochondrial apoptosis. Nature Reviews Molecular Cell Biology 24 (10), pp. 732 - 748 (2023)

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Pedrera, L.; Ros, U.; García-Sáez, A. J.: Calcium as a master regulator of ferroptosis and other types of regulated necrosis. Cell Calcium 114, 102778 (2023)

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Rieger, J.; Fitz, M.; Fischer, S. M.; Wallmeroth, N.; Flores-Romero, H.; Fischer, N. M.; Brand, L. H.; García-Sáez, A. J.; Berendzen, K. W.; Mira-Rodado, V.: Exploring the Binding Affinity of the ARR2 GARP DNA Binding Domain via Comparative Methods. Genes 14 (8), 1638 (2023)

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Garcia-Saez, A. J.: Dying in self-defense: cell death signaling in animals and plants. Cell Death and Differentiation (2023)

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Vitale, I.; Pietrocola, F.; Guilbaud, E.; Aaronson, S. A.; Abrams, J. M.; Adam, D.; Agostini, M.; Agostinis, P.; Alnemri, E. S.; Altucci, L. et al.; Amelio, I.; Andrews, D. W.; Aqeilan, R. I.; Arama, E.; Baehrecke, E. H.; Balachandran, S.; Bano, D.; Barlev, N. A.; Bartek, J.; Bazan, N. G.; Becker, C.; Bernassola, F.; Bertrand, M. J. M.; Bianchi, M. E.; Blagosklonny, M. V.; Blander, J. M.; Blandino, G.; Blomgren, K.; Borner, C.; Bortner, C. D.; Bove, P.; Boya, P.; Brenner, C.; Broz, P.; Brunner, T.; Damgaard, R. B.; Calin, G. A.; Campanella, M.; Candi, E.; Carbone, M.; Carmona-Gutierrez, D.; Cecconi, F.; Chan, F. K.-M.; Chen, G.-Q.; Chen, Q.; Chen, Y. H.; Cheng, E. H.; Chipuk, J. E.; Cidlowski, J. A.; Ciechanover, A.; Ciliberto, G.; Conrad, M.; Cubillos-Ruiz, J. R.; Czabotar, P. E.; D’Angiolella, V.; Daugaard, M.; Dawson, T. M.; Dawson, V. L.; De Maria, R.; De Strooper, B.; Debatin, K.-M.; Deberardinis, R. J.; Degterev, A.; Del Sal, G.; Deshmukh, M.; Di Virgilio, F.; Diederich, M.; Dixon, S. J.; Dynlacht, B. D.; El-Deiry, W. S.; Elrod, J. W.; Engeland, K.; Fimia, G. M.; Galassi, C.; Ganini, C.; Garcia-Saez, A. J.; Garg, A. D.; Garrido, C.; Gavathiotis, E.; Gerlic, M.; Ghosh, S.; Green, D. R.; Greene, L. A.; Gronemeyer, H.; Häcker, G.; Hajnóczky, G.; Hardwick, J. M.; Haupt, Y.; He, S.; Heery, D. M.; Hengartner, M. O.; Hetz, C.; Hildeman, D. A.; Ichijo, H.; Inoue, S.; Jäättelä, M.; Janic, A.; Joseph, B.; Jost, P. J.; Kanneganti, T.-D.; Karin, M.; Kashkar, H.; Kaufmann, T.; Kelly, G. L.; Kepp, O.; Kimchi, A.; Kitsis, R. N.; Klionsky, D. J.; Kluck, R.; Krysko, D. V.; Kulms, D.; Kumar, S.; Lavandero, S.; Lavrik, I. N.; Lemasters, J. J.; Liccardi, G.; Linkermann, A.; Lipton, S. A.; Lockshin, R. A.; López-Otín, C.; Luedde, T.; MacFarlane, M.; Madeo, F.; Malorni, W.; Manic, G.; Mantovani, R.; Marchi, S.; Marine, J.-C.; Martin, S. J.; Martinou, J.-C.; Mastroberardino, P. G.; Medema, J. P.; Mehlen, P.; Meier, P.; Melino, G.; Melino, S.; Miao, E. A.; Moll, U. M.; Muñoz-Pinedo, C.; Murphy, D. J.; Niklison-Chirou, M. V.; Novelli, F.; Núñez, G.; Oberst, A.; Ofengeim, D.; Opferman, J. T.; Oren, M.; Pagano, M.; Panaretakis, T.; Pasparakis, M.; Penninger, J. M.; Pentimalli, F.; Pereira, D. M.; Pervaiz, S.; Peter, M. E.; Pinton, P.; Porta, G.; Prehn, J. H. M.; Puthalakath, H.; Rabinovich, G. A.; Rajalingam, K.; Ravichandran, K. S.; Rehm, M.; Ricci, J.-E.; Rizzuto, R.; Robinson, N.; Rodrigues, C. M. P.; Rotblat, B.; Rothlin, C. V.; Rubinsztein, D. C.; Rudel, T.; Rufini, A.; Ryan, K. M.; Sarosiek, K. A.; Sawa, A.; Sayan, E.; Schroder, K.; Scorrano, L.; Sesti, F.; Shao, F.; Shi, Y.; Sica, G. S.; Silke, J.; Simon, H.-U.; Sistigu, A.; Stephanou, A.; Stockwell, B. R.; Strapazzon, F.; Strasser, A.; Sun, L.; Sun, E.; Sun, Q.; Szabadkai, G.; Tait, S. W. G.; Tang, D.; Tavernarakis, N.; Troy, C. M.; Turk, B.; Urbano, N.; Vandenabeele, P.; Vanden Berghe, T.; Vander Heiden, M. G.; Vanderluit, J. L.; Verkhratsky, A.; Villunger, A.; von Karstedt, S.; Voss, A. K.; Vousden, K. H.; Vucic, D.; Vuri, D.; Wagner, E. F.; Walczak, H.; Wallach, D.; Wang, R.; Wang, Y.; Weber, A.; Wood, W.; Yamazaki, T.; Yang, H.-T.; Zakeri, Z.; Zawacka-Pankau, J. E.; Zhang, L.; Zhang, H.; Zhivotovsky, B.; Zhou, W.; Piacentini, M.; Kroemer, G.; Galluzzi, L.: Apoptotic cell death in disease—Current understanding of the NCCD 2023. Cell Death and Differentiation 30 (5), pp. 1097 - 1154 (2023)

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Holtmannspötter, M.; Wienbeuker, E.; Dellmann, T.; Watrinet, I.; García-Sáez, A. J.; Johnsson, K.; Kurre, R.; Piehler, J.: Reversible Live-Cell Labeling with Retro-engineered HaloTags Enables Long-Term High- and Super-Resolution Imaging. Angewandte Chemie, International Edition in English 62 (18), e202219050 (2023)

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Danial, J. S. H.; Jenner, A.; Garcia-Saez, A. J.; Cosentino, K.: Real-Time Growth Kinetics Analysis of Macromolecular Assemblies in Cells with Single Molecule Resolution. The Journal of Physical Chemistry A 127 (15), pp. 3490 - 3496 (2023)

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García Sáez, A.; The FEBS Journal Editorial Team: Editor Profile: Ana García Sáez. The FEBS Journal 290 (8), pp. 1940 - 1942 (2023)

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Flores-Romero, H.; Dadsena, S.; García-Sáez, A. J.: Mitochondrial pores at the crossroad between cell death and inflammatory signaling. Molecular Cell 83 (6), pp. 843 - 856 (2023)

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Shalaby, R.; Diwan, A.; Flores-Romero, H.; Hertlein, V.; Garcia-Saez, A. J.: Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation. Cell Death and Differentiation 30 (3), pp. 731 - 741 (2023)

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Maier, R.; Cuevas Arenas, R.; Zhang, F.; García-Sáez, A. J.; Schreiber, F.: Structural Insights into Polymer-Bounded Lipid Nanodiscs. Langmuir 39 (6), pp. 2450 - 2459 (2023)

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Pedrera, L.; Ros, U.; Fanani, M. L.; Lanio, M. E.; Epand, R. M.; Garcia-Saez, A. J.; Álvarez, C.: The Important Role of Membrane Fluidity on the Lytic Mechanism of the α-Pore-Forming Toxin Sticholysin I. toxins 15, 80 (2023)

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2022

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Wang, X.; Ros, U.; Agrawal, D.; Keller, E. C.; Slotta-Huspenina, J.; Dill, V.; Shen, B.; Shi, R.; Herold, T.; Belka, C. et al.; Mishra, R.; Bassermann, F.; Garcia Saez, A. J.; Jost, P. J.: MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF. Cell Death and Differentiation 28, pp. 3235 - 3250 (2022)

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Guéguinou, M.; Ibrahim, S.; Bourgeais, J.; Robert, A.; Pathak, T.; Zhang, X.; Crottès, D.; Dupuy, J.; Ternant, D.; Monbet, V. et al.; Guibon, R.; Flores-Romero, H.; Lefèvre, A.; Lerondel, S.; Le Pape, A.; Dumas, J.-F.; Frank, P. G.; Girault, A.; Chautard, R.; Guéraud, F.; García-Sáez, A. J.; Ouaissi, M.; Emond, P.; Sire, O.; Hérault, O.; Fromont-Hankard, G.; Vandier, C.; Tougeron, D.; Trebak, M.; Raoul, W.; Lecomte, T.: Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer. Cellular and Molecular Life Sciences 79 (6), 284 (2022)

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Cosentino, K.; Hertlein, V.; Jenner, A.; Dellmann, T.; Gojkovic, M.; Peña-Blanco, A.; Dadsena, S.; Wajngarten, N.; Danial, J. S. H.; Thevathasan, J. V. et al.; Mund, M.; Ries, J.; Garcia-Saez, A. J.: The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation. Molecular Cell 82 (5), pp. 933 - 949 (2022)

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Jenner, A.; Peña-Blanco, A.; Salvador-Gallego, R.; Ugarte-Uribe, B.; Zollo, C.; Ganief, T.; Bierlmeier, J.; Mund, M.; Lee, J. E.; Ries, J. et al.; Schwarzer, D.; Macek, B.; Garcia-Saez, A. J.: DRP1 interacts directly with BAX to induce its activation and apoptosis. The EMBO Journal 41 (8), e108587 (2022)

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Danial, J. S. H.; Quintana, Y.; Ros, U.; Shalaby, R.; Margheritis, E. G.; Chumpen Ramirez, S.; Ungermann, C.; Garcia-Saez, A. J.; Cosentino, K.: Systematic Assessment of the Accuracy of Subunit Counting in Biomolecular Complexes Using Automated Single-Molecule Brightness Analysis. The Journal of Physical Chemistry Letters 13 (3), pp. 822 - 829 (2022)

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2021

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Flores-Romero, H.; Hohorst, L.; John, M.; Albert, M.-C.; King, L. E.; Beckmann, L.; Szabo, T.; Hertlein, V.; Luo, X.; Villunger, A. et al.; Frenzel, L. P.; Kashkar, H.; Garcia-Saez, A. J.: BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. The EMBO Journal 41 (2), e108690 (2021)

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Aguilar, M.; Nahas, K. A.; Barrera, F.; Bassereau, P.; Bastos, M.; Beales, P.; Bechinger, B.; Bonev, B.; Brand, I.; Chattopadhyay, A. et al.; DeGrado, W.; Fuchs, P.; Garcia Saez, A. J.; Hoogenboom, B.; Kapoor, S.; Rodríguez, P. M.; Molloy, J.; O’Shea, P.; Pabst, G.; Pal, S.; Rice, A.; Roux, A.; Sanderson, J.; Seddon, J.; Tamm, L. K.; Vijayakumar, A.: Behaviour and interactions of proteins and peptides with and within membranes; from simple models to cellular membranes: general discussion. Faraday Discussions 232, pp. 375 - 398 (2021)

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Aguilar, M.; Nahas, K. A.; Barrera, F.; Bassereau, P.; Bastos, M.; Beales, P.; Bechinger, B.; Bonev, B.; Brand, I.; Chattopadhyay, A. et al.; Clarke, R. J.; DeGrado, W.; Deplazes, E.; Garcia Saez, A. J.; Hoogenboom, B.; Lund, R.; Rodríguez, P. M.; O’Shea, P.; Pabst, G.; Pal, S.; Roux, A.; Sanderson, J.; Semeraro, E. F.; Sengupta, D.; Siegel, D. P.; Hag, L. v. '.; Vijayakumar, A.; Zoranić, L.: Theoretical and experimental studies of complex peptide–membrane systems: general discussion. Faraday Discussions 232, pp. 256 - 281 (2021)

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Aguilar, M.-I.; Nahas, K. A.; Barrera, F. N.; Bassereau, P.; Bechinger, B.; Brand, I.; Chattopadhyay, A.; Clarke, R. J.; DeGrado, W. F.; Deplazes, E. et al.; Fletcher, M.; Fraternali, F.; Fuchs, P.; Garcia Saez, A. J.; Gilbert, R.; Hoogenboom, B. W.; Jarin, Z.; O’Shea, P.; Pabst, G.; Pal, S.; Sanderson, J. M.; Seddon, J. M.; Sengupta, D.; Siegel, D. P.; Srivastava, A.; Tieleman, D. P.; Tripathy, M.; Utterström, J.; Vácha, R.; Vanni, S.; Voth, G. A.: Theoretical and experimental comparisons of simple peptide–membrane systems; towards defining the reaction space: general discussion. Faraday Discussions 232, pp. 149 - 171 (2021)

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Dadsena, S.; King, L. E.; García-Sáez, A. J.: Apoptosis regulation at the mitochondria membrane level. Biochimica et Biophysica Acta: BBA 1863 (12), 183716 (2021)

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Murad, F.; Garcia Saez, A. J.: Bcl-xL inhibits tBid and Bax via distinct mechanisms. Faraday Discussions 232, pp. 86 - 102 (2021)

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Danial, J. S. H.; Shalaby, R.; Cosentino, K.; Mahmoud, M. M.; Medhat, F.; Klenerman, D.; Garcia Saez, A. J.: DeepSinse: deep learning-based detection of single molecules. Bioinformatics 37 (21), pp. 3998 - 4000 (2021)

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Cosentino, K.; Hermann, E.; von Kügelgen, N.; Unsay, J. D.; Ros, U.; García-Sáez, A. J.: Force Mapping Study of Actinoporin Effect in Membranes Presenting Phase Domains. Toxins 13 (9), 669 (2021)

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Ros, U.; Pedrera, L.; Garcia-Saez, A. J.: Techniques for studying membrane pores. Current Opinion in Structural Biology 69, pp. 108 - 116 (2021)

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Pedrera, L.; Espiritu, R. A.; Ros, U.; Weber, J.; Schmitt, A.; Stroh, J.; Hailfinger, S.; von Karstedt, S.; García-Sáez, A. J.: Ferroptotic pores induce Ca²⁺ fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death and Differentiation 28 (5), pp. 1644 - 1657 (2021)

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Dadsena, S.; Zollo, C.; García-Sáez, A. J.: Mechanisms of mitochondrial cell death. Biochemical Society Transactions 49 (2), pp. 663 - 674 (2021)

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Dadsena, S.; Jenner, A.; García-Sáez, A. J.: Mitochondrial outer membrane permeabilization at the single molecule level. Cellular and Molecular Life Sciences 78 (8), pp. 3777 - 3790 (2021)

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2020

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Serulla, M.; Ichim, G.; Stojceski, F.; Grasso, G.; Afonin, S.; Heulot, M.; Schober, T.; Roth, R.; Godefroy, C.; Milhiet, P.-E. et al.; Das, K.; García-Sáez, A. J.; Danani, A.; Widmann, C.: TAT-RasGAP_317-326 kills cells by targeting inner-leaflet–enriched phospholipids. Proceedings of the National Academy of Sciences of the United States of America 117 (50), pp. 31871 - 31881 (2020)

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Journal Article

Shalaby, R.; Flores-Romero, H.; García-Sáez, A. J.: The Mysteries around the BCL-2 Family Member BOK. Biomolecules 10, 1638 (2020)

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Flores-Romero, H.; García-Sáez, A. J.: Lipids glue BAK dimers together. Nature Structural & Molecular Biology 27 (11), pp. 1003 - 1004 (2020)

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Flores‐Romero, H.; Ros, U.; Garcia-Saez, A. J.: Pore formation in regulated cell death. The EMBO Journal 39 (23), e105753 (2020)

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García-Sáez, A. J.: The BCL-2 family saga. Nature Reviews Molecular Cell Biology 21 (10), pp. 564 - 565 (2020)

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Journal Article

Lindenboim, L.; Grozki, D.; Amsalem-Zafran, A. R.; Peña-Blanco, A.; Gundersen, G. G.; Borner, C.; Hodzic, D.; García-Sáez, A. J.; Worman, H. J.; Stein, R.: Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins. Cell Death Discovery 6, 90 (2020)

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Peña-Blanco, A.; Haschka, M. D.; Jenner, A.; Zuleger, T.; Proikas-Cezanne, T.; Villunger, A.; García-Sáez, A. J.: Drp1 modulates mitochondrial stress responses to mitotic arrest. Cell Death and Differentiation 27 (9), pp. 2620 - 2634 (2020)

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Diestelkoetter-Bachert, P.; Beck, R.; Reckmann, I.; Hellwig, A.; Garcia Saez, A. J.; Zelman-Hopf, M.; Hanke, A.; Nunes Alves, A.; Wade, R. C.; Mayer, M. P. et al.; Wieland, F.: Structural characterization of an Arf dimer interface: molecular mechanism of Arf-dependent membrane scission. FEBS Letters 594 (14), pp. 2240 - 2253 (2020)

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Journal Article

Ros Quincoces, U. L.; Pedrera, L.; Garcia Saez, A. J.: Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis. International Journal of Molecular Sciences 21 (7), 2412 (2020)

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Kuwana, T.; King, L. E.; Cosentino, K.; Suess, J.; Garcia-Saez, A. J.; Garcia-Saez, A. J.; Gilmore, A. P.; Newmeyer, D. D.: Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization. Journal of Biological Chemistry 295 (6), pp. 1623 - 1636 (2020)

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Singh, P. K.; Roukounakis, A.; Weber, A.; Das, K. K.; Sohm, B.; Villunger, A.; Garcia Saez, A. J.; Häcker, G.: Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim. Cell Death and Differentiation 27 (2), pp. 434 - 450 (2020)

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2019

Journal Article

Hertlein, V.; Flores-Romero, H.; Das, K. K.; Fischer, S.; Heunemann, M.; Calleja-Felipe, M.; Knafo, S.; Hipp, K.; Harter, K.; Fitzgerald, J. C. et al.; García-Sáez, A. J.: MERLIN: a novel BRET-based proximity biosensor for studying mitochondria-ER contact sites. Life science alliance 3 (1), e201900600 (2019)

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Flores-Romero, H.; Landeta, O.; Ugarte-Uribe, B.; Cosentino, K.; García-Porras, M.; García-Sáez, A. J.; Basañez, G.: BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL. Cell Death and Differentiation 26 (10), pp. 1880 - 1894 (2019)

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Flores-Romero, H.; García-Sáez, A. J.: The Incomplete Puzzle of the BCL2 Proteins. Cells 8 (10), 1176 (2019)

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Teucher, M.; Zhang, H.; Bader, V.; Winklhofer, K. F.; García-Sáez, A. J.; Rajca, A.; Bleicken, S.; Bordignon, E.: A new perspective on membrane-embedded Bax oligomers using DEER and bioresistant orthogonal spin labels. Scientific Reports 9, 13013 (2019)

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Danial, J. S. H.; Garcia-Saez, A. J.: Quantitative analysis of super-resolved structures using ASAP. Nature Methods 16 (8), pp. 711 - 714 (2019)

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Journal Article

Flores-Romero, H.; García-Sáez, A. J.: MAVS-induced mitochondrial membrane remodeling. The FEBS Journal 286 (8), pp. 1540 - 1542 (2019)

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Journal Article

Dimou, E.; Cosentino, K.; Platonova, E.; Ros, U.; Sadeghi, M.; Kashyap, P.; Katsinelos, T.; Wegehingel, S.; Noé, F.; García-Sáez, A. J. et al.; Ewers, H.; Nickel, W.: Single event visualization of unconventional secretion of FGF2. Journal of Cell Biology 218 (2), pp. 683 - 699 (2019)

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2018

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Bleicken, S.; Assafa, T. E.; Stegmueller, C.; Wittig, A.; Garcia-Saez, A. J.; Bordignon, E.: Topology of active, membrane-embedded Bax in the context of a toroidal pore. Cell Death and Differentiation 25 (10), pp. 1717 - 1731 (2018)

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Journal Article

Unsay, J. D.; Murad, F.; Hermann, E.; Ries, J.; García-Sáez, A. J.: Scanning Fluorescence Correlation Spectroscopy for Quantification of the Dynamics and Interactions in Tube Organelles of Living Cells. ChemPhysChem 19, pp. 3273 - 3278 (2018)

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Cosentino, K.; García-Sáez, A. J.: MIM through MOM: the awakening of Bax and Bak pores. The EMBO Journal 37 (17), e100340 (2018)

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Journal Article

Sánchez, M. F.; Murad, F.; Gülcüler Balta, G. S.; Martin-Villalba, A.; García-Sáez, A. J.; Carrer, D. C.: Early activation of CD95 is limited and localized to the cytotoxic synapse. The FEBS Journal 285 (15), pp. 2813 - 2827 (2018)

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Journal Article

Ugarte-Uribe, B.; Prévost, C.; Das, K. K.; Bassereau, P.; García-Sáez, A. J.: Drp1 polymerization stabilizes curved tubular membranes similar to those of constricted mitochondria. Journal of Cell Science 132 (4), jcs208603 (2018)

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Journal Article

Hantusch, A.; Das, K. K.; García-Sáez, A. J.; Brunner, T.; Rehm, M.: Bax retrotranslocation potentiates Bcl-x_L’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance. Cell Death and Disease 9 (4), 430 (2018)

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Galluzzi, L.; Vitale, I.; Aaronson, S. A.; Abrams, J. M.; Adam, D.; Agostinis, P.; Alnemri, E. S.; Altucci, L.; Amelio, I.; Andrews, D. W. et al.; Annicchiarico-Petruzzelli, M.; Antonov, A. V.; Arama, E.; Baehrecke, E. H.; Barlev, N. A.; Bazan, N. G.; Bernassola, F.; Bertrand, M. J. M.; Bianchi, K.; Blagosklonny, M. V.; Blomgren, K.; Borner, C.; Boya, P.; Brenner, C.; Campanella, M.; Candi, E.; Carmona-Gutierrez, D.; Cecconi, F.; Chan, F. K.-M.; Chandel, N. S.; Cheng, E. H.; Chipuk, J. E.; Cidlowski, J. A.; Ciechanover, A.; Cohen, G. M.; Conrad, M.; Cubillos-Ruiz, J. R.; Czabotar, P. E.; D'Angiolella, V.; Dawson, T. M.; Dawson, V. L.; De Laurenzi, V.; De Maria, R.; Debatin, K.-M.; DeBerardinis, R. J.; Deshmukh, M.; Di Daniele, N.; Di Virgilio, F.; Dixit, V. M.; Dixon, S. J.; Duckett, C. S.; Dynlacht, B. D.; El-Deiry, W. S.; Elrod, J. W.; Fimia, G. M.; Fulda, S.; García-Sáez, A. J.; Garg, A. D.; Garrido, C.; Gavathiotis, E.; Golstein, P.; Gottlieb, E.; Green, D. R.; Greene, L. A.; Gronemeyer, H.; Gross, A.; Hajnoczky, G.; Hardwick, J. M.; Harris, I. S.; Hengartner, M. O.; Hetz, C.; Ichijo, H.; Jäättelä, M.; Joseph, B.; Jost, P. J.; Juin, P. P.; Kaiser, W. J.; Karin, M.; Kaufmann, T.; Kepp, O.; Kimchi, A.; Kitsis, R. N.; Klionsky, D. J.; Knight, R. A.; Kumar, S.; Lee, S. W.; Lemasters, J. J.; Levine, B.; Linkermann, A.; Lipton, S. A.; Lockshin, R. A.; López-Otín, C.; Lowe, S. W.; Luedde, T.; Lugli, E.; MacFarlane, M.; Madeo, F.; Malewicz, M.; Malorni, W.; Manic, G.; Marine, J.-C.; Martin, S. J.; Martinou, J.-C.; Medema, J. P.; Mehlen, P.; Meier, P.; Melino, S.; Miao, E. A.; Molkentin, J. D.; Moll, U. M.; Muñoz-Pinedo, C.; Nagata, S.; Nuñez, G.; Oberst, A.; Oren, M.; Overholtzer, M.; Pagano, M.; Panaretakis, T.; Pasparakis, M.; Penninger, J. M.; Pereira, D. M.; Pervaiz, S.; Peter, M. E.; Piacentini, M.; Pinton, P.; Prehn, J. H. M.; Puthalakath, H.; Rabinovich, G. A.; Rehm, M.; Rizzuto, R.; Rodrigues, C. M. P.; Rubinsztein, D. C.; Rudel, T.; Ryan, K. M.; Sayan, E.; Scorrano, L.; Shao, F.; Shi, Y.; Silke, J.; Simon, H.-U.; Sistigu, A.; Stockwell, B. R.; Strasser, A.; Szabadkai, G.; Tait, S. W. G.; Tang, D.; Tavernarakis, N.; Thorburn, A.; Tsujimoto, Y.; Turk, B.; Vanden Berghe, T.; Vandenabeele, P.; Vander Heiden, M. G.; Villunger, A.; Virgin, H. W.; Vousden, K. H.; Vucic, D.; Wagner, E. F.; Walczak, H.; Wallach, D.; Wang, Y.; Wells, J. A.; Wood, W.; Yuan, J.; Zakeri, Z.; Zhivotovsky, B.; Zitvogel, L.; Melino, G.; Kroemer, G.: Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation 25 (3), pp. 486 - 541 (2018)

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Böhler, P.; Stuhldreier, F.; Anand, R.; Kondadi, A. K.; Schlütermann, D.; Berleth, N.; Deitersen, J.; Wallot-Hieke, N.; Wu, W.; Frank, M. et al.; Niemann, H.; Wesbuer, E.; Barbian, A.; Luyten, T.; Parys, J. B.; Weidtkamp-Peters, S.; Borchardt, A.; Reichert, A. S.; Peña-Blanco, A.; García-Sáez, A. J.; Itskanov, S.; van der Bliek, A. M.; Proksch, P.; Wesselborg, S.; Stork, B.: The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane. Cell Death and Disease 9 (3), 286 (2018)

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Journal Article

Peña-Blanco, A.; García-Sáez, A. J.: Bax, Bak and beyond - mitochondrial performance in apoptosis. The FEBS Journal 285 (3), pp. 416 - 431 (2018)

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Journal Article

Bleicken, S.; Garcia-Saez, A. J.: Bcl-2 proteins: Unraveling the details of a complex and dynamic network. Molecular & Cellular Oncology 5 (1), e1384880 (2018)

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2017

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Kollek, M.; Voigt, G.; Molnar, C.; Murad, F.; Bertele, D.; Krombholz, C. F.; Bohler, S.; Labi, V.; Schiller, S.; Kunze, M. et al.; Geley, S.; Niemeyer, C. M.; Garcia-Saez, A. J.; Erlacher, M.: Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation. Journal of experimental medicine: JEM 214 (10), pp. 2967 - 2983 (2017)

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Journal Article

Danial, J. S.; García-Sáez, A. J.: Improving certainty in single molecule imaging. Current Opinion in Structural Biology 46, pp. 24 - 30 (2017)

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Journal Article

García-Sáez, A. J.: Cell scientist to watch – Ana Garcia-Saez. Journal of Cell Science 130 (17), pp. 2773 - 2774 (2017)

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Journal Article

Singh, P. K.; Roukounakis, A.; Frank, D. O.; Kirschnek, S.; Das, K. K.; Neumann, S.; Madl, J.; Römer, W.; Zorzin, C.; Borner, C. et al.; Haimovici, A.; Garcia-Saez, A. J.; Weber, A.; Häcker, G.: Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis. Genes & Development 31 (17), pp. 1754 - 1769 (2017)

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Journal Article

Artetxe, I.; Ugarte-Uribe, B.; Gil, D.; Valle, M.; Alonso, A.; García-Sáez, A. J.; Goñi, F. M.: Does Ceramide Form Channels? The Ceramide-Induced Membrane Permeabilization Mechanism. Biophysical Journal 113 (4), pp. 860 - 868 (2017)

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Journal Article

Ugarte-Uribe, B.; García-Sáez, A. J.: Apoptotic foci at mitochondria: in and around Bax pores. Philosophical Transactions B 372 (1726), 20160217 (2017)

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Journal Article

Bleicken, S.; Hantusch, A.; Das, K. K.; Frickey, T.; Garcia-Saez, A. J.: Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation. Nature Communications 8, 73 (2017)

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Das, K. K.; Shalaby, R.; García-Sáez, A. J.: Determinants of BH3 Sequence Specificity for the Disruption of Bcl-xL/cBid Complexes in Membranes. ACS Chemical Biology 12 (4), pp. 989 - 1000 (2017)

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Journal Article

Ros, U.; Peña-Blanco, A.; Hänggi, K.; Kunzendorf, U.; Krautwald, S.; Wong, W. W.-L.; García-Sáez, A. J.: Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium. Cell Reports 19, pp. 175 - 187 (2017)

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Cosentino, K.; García-Sáez, A. J.: Bax and Bak Pores: Are We Closing the Circle? Trends in Cell Biology 27 (4), pp. 266 - 275 (2017)

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Journal Article

Fernández-Marrero, Y.; Bleicken, S.; Das, K. K.; Bachmann, D.; Kaufmann, T.; Garcia-Saez, A. J.: The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID. The FEBS Journal 284 (5), pp. 711 - 724 (2017)

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Journal Article

Mesa-Galloso, H.; Delgado-Magnero, K. H.; Cabezas, S.; López-Castilla, A.; Hernández-González, J. E.; Pedrera, L.; Alvarez, C.; Peter Tieleman, D.; García-Sáez, A. J.; Lanio, M. E. et al.; Ros, U.; Valiente, P. A.: Disrupting a key hydrophobic pair in the oligomerization interface of the actinoporins impairs their pore-forming activity. Protein Science 26 (3), pp. 550 - 565 (2017)

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Journal Article

Unsay, J. D.; Cosentino, K.; Sporbeck, K.; García-Sáez, A. J.: Pro-apoptotic cBid and Bax exhibit distinct membrane remodeling activities: An AFM study. Biochimica et Biophysica Acta: BBA 1859 (1), pp. 17 - 27 (2017)

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2016

Journal Article

Fischer, A. W.; Bordignon, E.; Bleicken, S.; García-Sáez, A. J.; Jeschke, G.; Meiler, J.: Pushing the size limit of de novo structure ensemble prediction guided by sparse SDSL-EPR restraints to 200 residues: The monomeric and homodimeric forms of BAX. Journal of Structural Biology 195 (1), pp. 62 - 71 (2016)

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Journal Article

Navarro, G.; Cordomí, A.; Zelman-Femiak, M.; Brugarolas, M.; Moreno, E.; Aguinaga, D.; Perez-Benito, L.; Cortés, A.; Casadó, V.; Mallol, J. et al.; Canela, E. I.; Lluís, C.; Pardo, L.; García-Sáez, A. J.; McCormick, P. J.; Franco, R.: Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with G_i and G_s. BMC Biology 14, 26 (2016)

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García-Sáez, A. J.; Villunger, A.: MOMP in the absence of BH3-only proteins. Genes and Development 30 (8), pp. 878 - 880 (2016)

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Cosentino, K.; Ros, U.; Garcia-Saez, A. J.: Assembling the puzzle: Oligomerization of α-pore forming proteins in membranes. Biochimica et Biophysica Acta: BBA 1858 (3), pp. 457 - 466 (2016)

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Journal Article

Salvador-Gallego, R.; Mund, M.; Cosentino, K.; Schneider, J.; Unsay, J.; Schraermeyer, U.; Engelhardt, J.; Ries, J.; García-Sáez, A. J.: Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores. The EMBO Journal 35 (4), pp. 389 - 401 (2016)

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Journal Article

Bleicken, S.; Hofhaus, G.; Ugarte-Uribe, B.; Schröder, R.; García-Sáez, A. J.: cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities. Cell Death and Disease 7, e2121 (2016)

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2015

Journal Article

Sudji, I. R.; Subburaj, Y.; Frenkel, N.; García-Sáez, A. J.; Wink, M.: Membrane Disintegration Caused by the Steroid Saponin Digitonin Is Related to the Presence of Cholesterol. Molecules 20 (11), pp. 20146 - 20160 (2015)

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Ros, U.; Rodríguez-Vera, W.; Pedrera, L.; Valiente, P. A.; Cabezas, S.; Lanio, M. E.; García-Sáez, A. J.; Alvarez, C.: Differences in activity of actinoporins are related with the hydrophobicity of their N-terminus. Biochimie 116, pp. 70 - 78 (2015)

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Ana J. García-Sáez Publications

Journal Article (140)