Publications of Deryck J. Mills

Journal Article (46)

1.
Journal Article
Stautz, J.; Griwatz, D.; Kaltwasser, S.; Mehdipour, A. R.; Ketter, S.; Thiel, C.; Wunnicke, D.; Schrecker, M.; Mills, D. J.; Hummer, G. et al.; Vonck, J.; Hänelt, I.: A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ channel KtrAB. Nature Communications 16, 4252 (2025)
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2.
Journal Article
Lee, Y.; Wiriyasermkul, P.; Kongpracha, P.; Moriyama, S.; Mills, D. J.; Kühlbrandt, W.; Nagamori, S.: Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria. Nature Communications 13, 2708 (2022)
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3.
Journal Article
Parey, K.; Lasham, J.; Mills, D. J.; Djurabekova, A.; Haapanen, O.; Yoga, E. G.; Xie, H.; Kühlbrandt, W.; Sharma, V.; Vonck, J. et al.; Zickermann, V.: High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism. Science Advances 7 (46), eabj3221 (2021)
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4.
Journal Article
Heit, S.; Geurts, M. M. G.; Murphy, B. J.; Corey, R. A.; Mills, D. J.; Kühlbrandt, W.; Bublitz, M.: Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state. Science Advances 7 (46), eabj5255 (2021)
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5.
Journal Article
Wieferig, J.-P.; Mills, D. J.; Kühlbrandt, W.: Devitrification reduces beam-induced movement in cryo-EM. IUCrJ 8 (Pt 2), pp. 186 - 194 (2021)
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6.
Journal Article
Cunha, E. S.; Chen, X.; Sanz-Gaitero, M.; Mills, D. J.; Luecke, H.: Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution. Nature Communications 12 (1), 230 (2021)
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7.
Journal Article
Mills, D. J.: Setting up and operating a cryo-EM laboratory. Quarterly Reviews of Biophysics 54, e2 (2021)
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8.
Journal Article
Ebenhoch, R.; Prinz, S.; Kaltwasser, S.; Mills, D. J.; Meinecke, R.; Rübbelke, M.; Reinert, D.; Bauer, M.; Weixler, L.; Zeeb, M. et al.; Vonck, J.; Nar, H.: A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proceedings of the National Academy of Sciences of the United States of America 117 (50), pp. 31838 - 31849 (2020)
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9.
Journal Article
Wu, D.; Grund, T. N.; Welsch, S.; Mills, D.; Michel, M.; Safarian, S.; Michel, H.: Structural basis for amino acid exchange by a human heteromeric amino acid transporter. Proceedings of the National Academy of Sciences of the United States of America 117 (35), 202008111, pp. 21281 - 21287 (2020)
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10.
Journal Article
Tascón, I.; Sousa, J. S.; Corey, R. A.; Mills, D. J.; Griwatz, D.; Aumüller, N.; Mikusevic, V.; Stansfeld, P. J.; Vonck, J.; Hänelt, I.: Structural basis of proton-coupled potassium transport in the KUP family. Nature Communications 11, 626 (2020)
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11.
Journal Article
Brünle, S.; Eisinger, M. L.; Poppe, J.; Mills, D. J.; Langer, J. D.; Vonck, J.; Ermler, U.: Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism. Proceedings of the National Academy of Sciences of the United States of America 52 (116), pp. 26497 - 26504 (2019)
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12.
Journal Article
Parey, K.; Haapanen, O.; Sharma, V.; Köfeler, H.; Züllig, T.; Prinz, S.; Siegmund, K.; Wittig, I.; Mills, D.; Vonck, J. et al.; Kühlbrandt, W.; Zickermann, V.: High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease. Science Advances 5 (12), p. eaax9484 (2019)
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13.
Journal Article
Pfeil-Gardiner, O.; Mills, D. J.; Vonck, J.; Kühlbrandt, W.: A comparative study of single-particle cryo-EM with liquid-nitrogen and liquid-helium cooling. IUCrJ 6, pp. 1099 - 1105 (2019)
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14.
Journal Article
Safarian, S.; Hahn, A.; Mills, D.; Radloff, M.; Eisinger, M. L.; Nikolaev, A.; Meier-Credo, J.; Melin, F.; Miyoshi, H.; Gennis, R.B. et al.; Sakamoto, J.; Langer, J. D.; Hellwig, P.; Kühlbrandt, W.; Michel, H.: Active site rearrangement and structural divergence in prokaryotic respiratory oxidases. Science 366 (6461), pp. 100 - 104 (2019)
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15.
Journal Article
Murphy, B. J.; Klusch, N.; Langer, J. D.; Mills, D.; Yildiz, Ö.; Kühlbrandt, W.: Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F1-Fo coupling. Science 364 (6446), eaaw9128, p. 1155 (2019)
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16.
Journal Article
Parey, K.; Brandt, U.; Xie, H.; Mills, D. J.; Siegmund, K.; Vonck, J.; Kühlbrandt, W.; Zickermann, V.: Cryo-EM structure of respiratory complex I at work. eLife 7, e39213 (2018)
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17.
Journal Article
Sousa, J. S.; Calisto, F.; Langer, J. D.; Mills, D. J.; Refojo, P. N.; Teixeira, M.; Kühlbrandt, W.; Vonck, J.; Pereira, M. M.: Structural basis for energy transduction by respiratory alternative complex III. Nature Communications 9, 1728 (2018)
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18.
Journal Article
Hahn, A.; Vonck, J.; Mills, D. J.; Meier, T.; Kühlbrandt, W.: Structure, mechanism, and regulation of the chloroplast ATP synthase. Science 360 (6389), pp. 1 - 10 (2018)
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19.
Journal Article
Klusch, N.; Murphy, B. J.; Mills, D.; Yildiy, Ö.; Kühlbrandt, W.: Structural basis of proton translocation and force generation in mitochondrial ATP synthase. eLife 6, e33274 (2017)
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20.
Journal Article
Bausewein, T.; Mills, D. J.; Langer, J. D.; Nitschke, B.; Nussberger, S.; Kühlbrandt, W.: Cryo-EM Structure of the TOM Core Complex from Neurospora crassa. Cell 170 (4), pp. 693 - 700 (2017)
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21.
Journal Article
van Pee, K.; Neuhaus, A.; D'Imprima, E.; Mills, D. J.; Kühlbrandt, W.; Yildiz, Ö.: CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin. eLife 6, e23644 (2017)
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22.
Journal Article
Diskowski, M.; Mehdipour, A. R.; Wunnicke, D.; Mills, D. J.; Mikusevic, V.; Bärland, N.; Hoffmann, J.; Morgner, N.; Steinhoff, H.-J.; Hummer, G.: Helical jackknives control the gates of the double-pore K+ uptake system KtrABs. eLife, pp. 1 - 21 (2017)
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23.
Journal Article
Kohler, R.; Mooney, R. A.; Mills, D. J.; Landick, R.; Cramer, P.: Architecture of a transcribing-translating expressome. Science 356, pp. 194 - 197 (2017)
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24.
Journal Article
López-Alonso, J. P.; Kaminishi, T.; Kikuchi, T.; Hirata, Y.; Iturrioz, I.; Dhimole, N.; Schedlbauer, A.; Hase, Y.; Goto, S.; Kurita, D. et al.; Muto, A.; Zhou, S.; Naoe, C.; Mills, D. J.; Gil-Carton, D.; Takemoto, C.; Himeno, H.; Fucini, P.; Connell, S. R.: RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket. Nucleic Acids Research 45 (11), pp. 6945 - 6959 (2017)
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25.
Journal Article
Schulz, S.; Wilkes, M.; Mills, D. J.; Kühlbrandt, W.; Meier, T.: Molecular architecture of the N‐type ATPase rotor ring from Burkholderia pseudomallei. EMBO Reports 18 (6), pp. 1 - 10 (2017)
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26.
Journal Article
Vonck, J.; Mills, D. J.: Advances in high-resolution cryo-EM of oligomeric enzymes. Current Opinion in Structural Biology 46, pp. 48 - 54 (2017)
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27.
Journal Article
Sousa, J. S.; Mills, D. J.; Vonck, J.; Kühlbrandt, W.: Functional asymmetry and electron flow in the bovine respirasome. eLife 5, e21290 (2016)
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28.
Journal Article
Vonck, J.; Parcej, D. N.; Mills, D. J.: Structure of Alcohol Oxidase from Pichia pastoris by Cryo-Electron Microscopy. PLOS ONE 11 (7), e0159476 (2016)
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29.
Journal Article
Chaudhury, P.; Neiner, T.; D'Imprima, E.; Banerjee, A.; Reindl, S.; Ghosh, A.; Arvai, A. S.; Mills, D. J.; van der Does, C.; Tainer, J. A. et al.; Vonck, J.; Albers, S.: The nucleotide-dependent interaction of FlaH and FlaI isessential for assembly and function of the archaellum motor. Molecular Microbiology 99 (4), pp. 674 - 685 (2016)
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30.
Journal Article
D'Imprima, E.; Mills, D. J.; Parey, K.; Brandt, U.; Kühlbrandt, W.; Zickermann, V.; Vonck, J.: Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1857 (12), pp. 1935 - 1942 (2016)
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31.
Journal Article
Hahn, A.; Parey, K.; Bublitz, M.; Mills, D. J.; Zickermann, V.; Vonck, J.; Kühlbrandt, W.; Meier, T.: Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology. Molecular Cell 63, pp. 1 - 12 (2016)
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32.
Journal Article
Allegretti, M.; Klusch, N.; Mills, D. J.; Vonck, J.; Kühlbrandt, W.; Davies, K. M.: Horizontal membrane-intrinsic α-helices in the stator a-subunit of an F-type ATP synthase. Nature 521, pp. 237 - 240 (2015)
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33.
Journal Article
Jiko, C.; Davies, K. M.; Shinzawa-Itoh, K.; Tani, K.; Maeda, S.; Mills, D. J.; Tsukihara, T.; Fujiyoshi, Y.; Kühlbrandt, W.; Gerle, C.: Bovine F1F0 ATP synthase monomers bend the lipid bilayer in 2D membrane crystals. eLife 4, e06119 (2015)
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34.
Journal Article
Fischer, M.; Rhinow, D.; Zhu, Z.; Mills, D. J.; Zhao, Z. K.; Vonck, J.; Grininger, M.: Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS. Protein Science 24 (6), pp. 987 - 995 (2015)
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35.
Journal Article
Allegretti, M.; Mills, D. J.; McMullen, G.; Kühlbrandt, W.; Vonck, J.: Atomic model of the F420-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector. eLife 3, e01963 (2014)
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36.
Journal Article
Daum, B.; Quax, T. E. F.; Sachse, M.; Mills, D. J.; Reimann, J.; Yildiz, Ö.; Häder, S.; Saveanu, C.; Forterre, P.; Albers, S.-V. et al.; Kühlbrandt, W.; Prangishvili, D.: Self-assembly of the general membrane-remodeling protein PVAP into sevenfold virus-associated pyramids. Proceedings of the National Academy of Sciences of the United States of America 111 (10), pp. 3829 - 3834 (2014)
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37.
Journal Article
Davies, K. M.; Daum, B.; Gold, V. A. M.; Mühleip, A. W.; Brandt, T.; Blum, T.; Mills, D. J.; Kühlbrandt, W.: Visualization of ATP Synthase Dimers in Mitochondria by Electron Cryo-tomography. Journal of Visualized Experiments (91 doi: 10.3791/51228), e51228 (2014)
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38.
Journal Article
Mills, D. J.; Vitt, S.; Strauss, M.; Shima, S.; Vonck, J.: De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. eLife 2, e00218 (2013)
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39.
Journal Article
Ciccarelli, L.; Connell, S. R.; Enderle, M.; Mills, D. J.; Vonck, J.; Grininger, M.: Structure and Conformational Variability of the Mycobacterium tuberculosis Fatty Acid Synthase Multienzyme Complex. Structure 21 (7), pp. 1251 - 1257 (2013)
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40.
Journal Article
Banerjee, A.; Ghosh, A.; Mills, D. J.; Kahnt, J.; Vonck, J.; Albers, S.-V.: FlaX, A Unique Component of the Crenarchaeal Archaellum, Forms Oligomeric Ring-shaped Structures and Interacts with the Motor ATPase FlaI. The Journal of Biological Chemistry 287 (52), pp. 43322 - 43330 (2012)
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41.
Journal Article
Hizlan, D.; Robson, A.; Whitehouse, S.; Gold, V. A.; Vonck, J.; Mills, D.; Kühlbrandt, W.; Collinson, I.: Structure of the SecY Complex Unlocked by a Preprotein Mimic. Cell Reports 1 (1), pp. 21 - 28 (2012)
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42.
Journal Article
Althoff, T.; Mills, D. J.; Popot, J.-L.; Kühlbrandt, W.: Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1. EMBO Journal 30, pp. 4652 - 4664 (2011)
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43.
Journal Article
Gipson, P.; Mills, D. J.; Wouts, R.; Grininger, M.; Vonck, J.; Kühlbrandt, W.: Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy. Proceedings of the National Academy of Sciences of the United States of America 107 (20), pp. 9164 - 9169 (2010)
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44.
Journal Article
Kamal, M. M.; Mills, D.; Grzybeck, M.; Howard, J.: Measurement of the membrane curvature preference of phospholipids reveals only weak coupling between lipid shape and leaflet curvature. Proceedings of the National Academy of Sciences of the United States of America 106 (52), pp. 22245 - 22250 (2009)
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45.
Journal Article
Schmidt-Krey, I.; Kanaoka, Y.; Mills, D. J.; Lam, B. K.; Irikura, D.; Haase, W.; Austen, K. F.; Kühlbrandt, W.: Human Leukotriene C4 Synthase at 4.5 Å Resolution in Projection. Structure 12, pp. 2009 - 2014 (2004)
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46.
Journal Article
Behlau, M.; Mills, D. J.; Quader, H.; Kühlbrandt, W.; Vonck, J.: Projection structure of the monomeric porin OmpG at 6 å resolution. Journal of Molecular Biology (London) 305 (1), pp. 71 - 77 (2001)
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Book Chapter (1)

47.
Book Chapter
Mills, D. J.; Vonck, J.: Choice and Maintenance of Equipment for Electron Crystallography. In: Electron Crystallography of Soluble and Membrane Proteins: Methods and Protocols, Vol. 995, pp. 331 - 351 (Eds. Schmidt-Krey, I.; Cheng, Y.). Springer Science+Business Media New York 2013, Humana Totowa, NJ (2013)
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Proceedings (2)

48.
Proceedings
Cryo-EM structure of the alternative complex III from Rhodothermus marinus (Biochim. Biophys. Acta (BBA) - Bioenergetics, 1859). (2018), 1 p.
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49.
Proceedings
The cryo EM structure of respiratory complex I from Yarrowia lipolytica (Biochim. Biophys. Acta (BBA) - Bioenergetics, 1859). Budapest, Hungary (2018), 01 p.
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