Lasham, J.; Djurabekova, A.; Zickermann, V.; Vonck, J.; Sharma, V.: Role of Protonation States in the Stability of Molecular Dynamics Simulations of High-Resolution Membrane Protein Structures. The Journal of Physical Chemistry B 128 (10), pp. 2304 - 2316 (2024)
Fuss, M. F.; Wieferig, J.-P.; Corey, R. A.; Hellmich, Y.; Tascón, I.; Sousa, J. S.; Stansfeld, P. J.; Vonck, J.; Hänelt, I.: Cyclic di-AMP traps proton-coupled K+ transporters of the KUP family in an inward-occluded conformation. Nature Communications 14, 3683 (2023)
Schiller, J.; Laube, E.; Wittig, I.; Kühlbrandt, W.; Vonck, J.; Zickermann, V.: Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling. Science Advances 8 (46), eadd3855 (2022)
Ebenhoch, R.; Prinz, S.; Kaltwasser, S.; Mills, D. J.; Meinecke, R.; Rübbelke, M.; Reinert, D.; Bauer, M.; Weixler, L.; Zeeb, M.et al.; Vonck, J.; Nar, H.: A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proceedings of the National Academy of Sciences of the United States of America 117 (50), pp. 31838 - 31849 (2020)
Parey, K. K.; Wirth, C.; Vonck, J.; Zickermann, V.: Respiratory complex I - structure, mechanism and evolution. Current Opinion in Structural Biology 63 (2020)
Tascón, I.; Sousa, J. S.; Corey, R. A.; Mills, D. J.; Griwatz, D.; Aumüller, N.; Mikusevic, V.; Stansfeld, P. J.; Vonck, J.; Hänelt, I.: Structural basis of proton-coupled potassium transport in the KUP family. Nature Communications 11, 626 (2020)
Joppe, M.; D'Imprima, E.; Salustros, N.; Paithankar, K. S.; Vonck, J.; Grininger, M.; Kühlbrandt, W.: The resolution revolution in cryoEM requires high-quality sample preparation: a rapid pipeline to a high-resolution map of yeast fatty acid synthase. IUCrJ 7 (Pt 2), pp. 220 - 227 (2020)
Cossio, P.; Allegretti, M.; Mayer, F.; Müller, V.; Vonck, J.; Hummer, G.: Bayesian inference of rotor ring stoichiometry from electron microscopy images of archaeal ATP synthase. Microscopy 67 (5), pp. 266 - 273 (2018)
Sousa, J. S.; Calisto, F.; Langer, J. D.; Mills, D. J.; Refojo, P. N.; Teixeira, M.; Kühlbrandt, W.; Vonck, J.; Pereira, M. M.: Structural basis for energy transduction by respiratory alternative complex III. Nature Communications 9, 1728 (2018)
Vonck, J.; Parcej, D. N.; Mills, D. J.: Structure of Alcohol Oxidase from Pichia pastoris by Cryo-Electron Microscopy. PLOS ONE 11 (7), e0159476 (2016)
Chaudhury, P.; Neiner, T.; D'Imprima, E.; Banerjee, A.; Reindl, S.; Ghosh, A.; Arvai, A. S.; Mills, D. J.; van der Does, C.; Tainer, J. A.et al.; Vonck, J.; Albers, S.: The nucleotide-dependent interaction of FlaH and FlaI isessential for assembly and function of the archaellum motor. Molecular Microbiology 99 (4), pp. 674 - 685 (2016)
Hahn, A.; Parey, K.; Bublitz, M.; Mills, D. J.; Zickermann, V.; Vonck, J.; Kühlbrandt, W.; Meier, T.: Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology. Molecular Cell 63, pp. 1 - 12 (2016)
Salzer, R.; D'Imprima, E.; Gold, V. A. M.; Rose, I.; Drechsler, M.; Vonck, J.; Averhoff, B.: Topology and Structure/Function Correlation of Ring- and Gate-forming Domains in the Dynamic Secretin Complex of Thermus thermophilus. The Journal of Biological Chemistry 291 (28), pp. 14448 - 14456 (2016)
Fischer, M.; Rhinow, D.; Zhu, Z.; Mills, D. J.; Zhao, Z. K.; Vonck, J.; Grininger, M.: Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS. Protein Science 24 (6), pp. 987 - 995 (2015)
Allegretti, M.; Mills, D. J.; McMullen, G.; Kühlbrandt, W.; Vonck, J.: Atomic model of the F420-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector. eLife 3, e01963 (2014)
Zhang, C.; Allegretti, M.; Vonck, J.; Langer, J.; Marcia, M.; Peng, G.; Michel, H.: Production of fully assembled and active Aquifex aeolicus F1FO ATP synthase in Escherichia coli. Biochimica et Biophysica Acta (BBA) - General Subjects 1840 (1), pp. 34 - 40 (2014)
Mills, D. J.; Vitt, S.; Strauss, M.; Shima, S.; Vonck, J.: De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. eLife 2, e00218 (2013)
Ciccarelli, L.; Connell, S. R.; Enderle, M.; Mills, D. J.; Vonck, J.; Grininger, M.: Structure and Conformational Variability of the Mycobacterium tuberculosis Fatty Acid Synthase Multienzyme Complex. Structure 21 (7), pp. 1251 - 1257 (2013)
Banerjee, A.; Ghosh, A.; Mills, D. J.; Kahnt, J.; Vonck, J.; Albers, S.-V.: FlaX, A Unique Component of the Crenarchaeal Archaellum, Forms Oligomeric Ring-shaped Structures and Interacts with the Motor ATPase FlaI. The Journal of Biological Chemistry 287 (52), pp. 43322 - 43330 (2012)
Hakulinen, J. K.; Klyszejko, A. L.; Hoffmann, J.; Eckardt-Strelau, L.; Brutschy, B.; Vonck, J.; Meier, T.: Structural study on the architecture of the bacterial ATP synthase F0 motor. Proceedings of the National Academy of Sciences of the United States of America 109 (30), pp. E2050 - E2056 (2012)
Burkhardt, J.; Vonck, J.; Langer, J. D.; Salzer, R.; Averhoff, B.: Unusual N-terminal ααβαββα Fold of PilQ from Thermus thermophilus Mediates Ring Formation and Is Essential for Piliation. The Journal of Biological Chemistry 287 (11), pp. 8484 - 8494 (2012)
Burkhardt, J.; Vonck, J.; Averhoff, B.: Structure and Function of PilQ, a Secretin of the DNA Transporter from the Thermophilic Bacterium Thermus thermophilus HB27. The Journal of Biological Chemistry 286 (12), pp. 9977 - 9984 (2011)
Rhinow, D.; Vonck, J.; Schranz, M.; Beyer, A.: Ultrathin conductive carbon nanomembranes as support films for structural analysis of biological specimens. Physical Chemistry Chemical Physics 12, pp. 4345 - 4350 (2010)
Gipson, P.; Mills, D. J.; Wouts, R.; Grininger, M.; Vonck, J.; Kühlbrandt, W.: Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy. Proceedings of the National Academy of Sciences of the United States of America 107 (20), pp. 9164 - 9169 (2010)
Müller, V.; Pisa, K. Y.; Vonck, J.: ATP-Synthase der Archäen - Neue Einblicke in die Struktur und Funktion eines Energiewandlers. Biospektrum 1, pp. 19 - 21 (2010)
Matthies, D.; Preiss, L.; Klyszejko, A. L.; Muller, D. J.; Cook, G. M.; Vonck, J.; Meier, T.: The c13 Ring from a Thermoalkaliphilic ATP Synthase Reveals an Extended Diameter Due to a Special Structural Region. Journal of Molecular Biology 388 (3), pp. 611 - 618 (2009)
Vonck, J.; Pisa, K. Y.; Morgner, N.; Brutschy, B.; Müller, V.: Three-dimensional Structure of A1A0 ATP Synthase from the Hyperthermophilic Archaeon Pyrococcus furiosus by Electron Microscopy. The Journal of Biological Chemistry 284 (15), pp. 10110 - 10119 (2009)
Vonck, J.; Schäfer, E.: Supramolecular organization of protein complexes in the mitochondrial inner membrane. Biochimica et Biophysica Acta-Molecular Cell Research 1793 (1), pp. 117 - 124 (2009)
Johansson, P.; Wiltschi, B.; Kumari, P.; Kessler, B.; Vonrhein, C.; Vonck, J.; Oesterhelt, D.; Grininger, M.: Inhibition of the fungal fatty acid synthase type I multienzyme complex. Proceedings of the National Academy of Sciences of the United States of America 105 (35), pp. 12803 - 12808 (2008)
Fritz, M.; Klyszeijko, A. L.; Morgner, N.; Vonck, J.; Brutschy, B.; Muller, D. J.; Meier, T.; Müller, V.: An intermediate step in the evolution of ATPases - a hybrid F0–V0 rotor in a bacterial Na+ F1F0 ATP synthase. The FEBS Journal 275 (9), pp. 1999 - 2007 (2008)
Shastri, S.; Vonck, J.; Pfleger, N.; Haase, W.; Kühlbrandt, W.; Glaubitz, C.: Proteorhodopsin: Characterisation of 2D crystals by electron microscopy and solid state NMR. Biochimica et Biophysica Acta-Biomembranes 1768 (12), pp. 3012 - 3019 (2007)
Stocker, A.; Keis, S.; Vonck, J.; Cook, G. M.; Dimroth, P.: The Structural Basis for Unidirectional Rotation of Thermoalkaliphilic F1-ATPase. Structure 15 (8), pp. 904 - 914 (2007)
Meier, T.; Ferguson, S. A.; Cook, G. M.; Dimroth, P.; Vonck, J.: Structural Investigations of the Membrane-Embedded Rotor Ring of F-ATPase from Clostridium paradoxum. Journal of Bacteriology 188, pp. 7759 - 7764 (2006)
Schäfer, E.; Seelert, H.; Reifschneider, N. H.; Krause, F.; Dencher, N. A.; Vonck, J.: Architecture of Active Mammalian Respiratory Chain Supercomplexes. The Journal of Biological Chemistry 281, pp. 15370 - 15375 (2006)
Pogoryelov, D.; Yu, J.; Meier, T.; Vonck, J.; Dimroth, P.; Muller, D. J.: The c15 ring of the Spirulina platensis F-ATP synthase: F1/F0 symmetry mismatch is not obligatory. EMBO Reports 6 (11), pp. 1040 - 1044 (2005)
Meier, T.; Matthey, U.; von Ballmoos, C.; Vonck, J.; Krug von Nidda, T.; Kühlbrandt, W.; Dimroth, P.: Evidence for Structural Integrity in the Undecameric c-Rings Isolated from Sodium ATP Synthases. Journal of Molecular Biology (London) 325, pp. 389 - 397 (2003)
Vonck, J.; von Nidda, T. K.; Meier, T.; Matthey, U.; Mills, D. J.; Kühlbrandt, W.; Dimroth, P.: Molecular architecture of the undecameric rotor of a bacterial Na+-ATP synthase. Journal of Molecular Biology 321 (2), pp. 307 - 316 (2002)
Behlau, M.; Mills, D. J.; Quader, H.; Kühlbrandt, W.; Vonck, J.: Projection structure of the monomeric porin OmpG at 6 å resolution. Journal of Molecular Biology (London) 305 (1), pp. 71 - 77 (2001)
Vonck, J.: Parameters affecting specimen flatness of two-dimensional crystals for electron crystallography. Ultramicroscopy 85 (5), pp. 123 - 129 (2000)
Vonck, J.: Structure of the bacteriorhodopsin mutant F219L N intermediate revealed by electron crystallography. The EMBO Journal 19 (10), pp. 2152 - 2160 (2000)
Collinson, I.; Vonck, J.; Hizlan, D.: Using 2D Crystals to Analyze the Structure of Membrane Proteins. In: Methods in Molecular Biology, Vol. 1033, Chapter 4, pp. 47 - 65 (Eds. Rapaport, D.; Herrmann, J. M.). Springer Science+Business Media, New York (2013)
Mills, D. J.; Vonck, J.: Choice and Maintenance of Equipment for Electron Crystallography. In: Electron Crystallography of Soluble and Membrane Proteins: Methods and Protocols, Vol. 995, pp. 331 - 351 (Eds. Schmidt-Krey, I.; Cheng, Y.). Springer Science+Business Media New York 2013, Humana Totowa, NJ (2013)
Vonck, J.: Supramolecular Organization of the Respiratory Chain. In: A Structural Perspective on Respiratory Complex I: Structure and Function of NADH:ubiquinone oxidoreductase, pp. 247 - 277 (Ed. Sazanov, L.). Springer Science and Business Media, Dordrecht The Netherlands (2012)
The cryo EM structure of respiratory complex I from Yarrowia lipolytica (Biochim. Biophys. Acta (BBA) - Bioenergetics, 1859). Budapest, Hungary (2018), 01 p.
Researchers at the Max Planck Institute of Biophysics and the University of Cologne developed a new optical tool to study ferroptosis, a form of iron-driven cell death. Better understanding of how it spreads could open doors to new therapies.
On February 5, 2024, we participated in the “Frankfurt Stands Up for Democracy” demonstration, standing alongside nearly 20,000 participants representing over 100 institutions, organizations, and companies across the Frankfurt region.
The Max Planck Institute of Biophysics is part of the new science network Frankfurt Alliance together with 15 other research institutions in the Rhine-Main metropolitan area
The fellow program promotes cooperation between Max Planck Institutes and outstanding professors at universities. From March 2024, Müller-McNicoll will lead a small research group at the MPI in Frankfurt for five years to investigate RNA, the carrier of genetic information in the cell, and its regulation.