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COVID-19 research: Anti-viral strategy with double effect

July 29, 2020

When the SARS-CoV-2 virus penetrates human cells, it lets the human host cell produce proteins for it. One of these viral proteins, called PLpro, is essential for the replication and rapid spread of the virus. An international team of researchers led ...

A new approach for higher resolution structure determination of macromolecules in their native context

July 27, 2020

Cryo-electron tomography that was combined with subtomogram averaging (StA) has yielded high-resolution structures of macromolecules in their native context. However, high-resolution StA is not commonplace due to beam-induced sample drift, images ...

How smart, ultrathin nanosheets go fishing for proteins

July 20, 2020

An interdisciplinary team from Frankfurt am Main and Jena has developed a kind of bait with which to fish protein complexes out of mixtures. Thanks to this “bait”, the desired protein is available much faster for further examination in the electron ...

Water exchange in magnesium’s hydration shells impacts biological processes

July 02, 2020

The dynamics of water exchange in the first hydration shell of magnesium are important to a variety of biological phenomena. Despite the importance, the microscopic mechanism of water exchange could not be resolved so far since it is out of reach for ...

A molecular view on protein retrotranslocation

April 27, 2020

Researchers at Harvard Medical School (USA), New York University School of Medicine (USA) and the Max Planck Institute of Biophysics developed a model of how misfolded proteins are recognised and retrotranslocated by the Hrd1 ubiquitin ligase complex ...

Enzyme catalysis by selective compression of bulky ring-shaped substrates

April 14, 2020

High-resolution crystal structures of tertiary methylene-tetrahydromethanopterin (H4MPT)-substrate complexes show how the substrates NADP+ and methylene-H4MPT are, at first, bound into an open catalytic cleft and then transferred into a strained but ...

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