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The supply of the cells with energy is an essential process in all forms of life. Respiratory complex I plays a central role in aerobic energy metabolism but its molecular mechanism is still largely unknown. In a new study using cryo-electron ...

Researchers from the University of Otago, the Goethe University Frankfurt and the Max Planck Institute of Biophysics solved the cryo-EM structure of the cytochrome bd oxidase from Mycobacterium tuberculosis at a resolution of 2.5 Å. In conjunction ...

Methanogenic archaea use sophisticated enzyme systems to live in energy-limited anoxic environments. A key mechanism for saving energy is electron bifurcation, a reaction that ‘splits’ the energy of a pair of electrons, making one more strongly ...

Scientists at the Max Planck Institutes for Medical Research in Heidelberg, for Marine Microbiology in Bremen and for Biophysics in Frankfurt am Main, as well as the Radboud University in Nijmegen and other partners, have successfully determined the ...

Magnesium plays an essential role in many vital processes. To correctly describe its mode of action in biological systems by computer simulations, accurate models with atomistic resolution are crucial. Researchers in the group of Nadine Schwierz at ...

A key feature of SARS-CoV-2 is its spike protein, which extends from its surface and enables it to target and infect human cells. Extensive research has resulted in detailed static models of the spike protein, but these models do not capture the ...

Once again, a step has been taken towards clarifying the action of the neurotransmitter serotonin, often referred to as the "happiness hormone", to one of its receptors, 5-HT3AR. An international team of researchers has succeeded now in elucidating ...

For the first time, scientists at the Center for Integrative Infectious Diseases Research at the University Hospital Heidelberg, the Heidelberg European Molecular Biology Laboratory and the Max Planck Institute of Biophysics in Frankfurt have ...