Publications of the Institute | Max Planck Institute of Biophysics

2021

Journal Article

Hulleman, C. N.; Thorsen, R. Ø.; Kim, E.; Dekker, C.; Stallinga, S.; Rieger, B.: Simultaneous orientation and 3D localization microscopy with a Vortex point spread function. Nature Communications 12 (1), 5934 (2021)

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Rocha-Roa, C.; Orjuela, J. D.; Leidy, C.; Cossio, P.; Aponte-Santamaría, C.: Cardiolipin prevents pore formation in phosphatidylglycerol bacterial membrane models. FEBS Letters (2021)

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Weissbecker, J.; Boumrifak, C.; Breyer, M.; Wießalla, T.; Shevchenko, V.; Mager, T.; Slavov, C.; Alekseev , A.; Kovalev, K.; Gordeliy , V. et al.; Bamberg, E.; Wachtveitl, J.: The voltage dependent sidedness of the reprotonation of the retinal Schiff base determines the unique inward pumping of Xenorhodopsin. Angewandte Chemie, International Edition in English 60 (42), pp. 23010 - 23017 (2021)

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Mathioudaki, E.; Arvaniti, K.; Münke, C.; Drakonaki, A.; Vranakis, I.; Koutantou, M.; Psaroulaki, A.; Xie, H.; Tsiotis, G.: Expression, purification and characterization of the IcmG and IcmK proteins of the Type IVB secretion system from Coxiella burnetii. Protein Expression and Purification 186, 105905 (2021)

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Hollenstein, D. M.; Gérecová, G.; Romanov, N.; Ferrari, J.; Veis, J.; Janschitz, M.; Beyer, R.; Schüller, C.; Ogris, E.; Hartl, M. et al.; Ammerer, G.; Reiter, W.: A phosphatase-centric mechanism drives stress signaling response. EMBO Reports, e52476 (2021)

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Kung, J.; Meier, A.-K.; Willistein, M.; Weidenweber, S.; Demmer, U.; Ermler, U.; Boll, M.: Structural basis of cyclic 1,3-diene forming acyl-coenzyme A dehydrogenases. Chembiochem (2021)

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Erdbrügger, P.; Wilfling, F.: p62 condensates are a hub for proteasome-mediated protein turnover in the nucleus. Proceedings of the National Academy of Sciences of the United States of America 118 (37), e2113647118 (2021)

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Sanchez, C. P.; Patra, P.; Chang, S.-Y. S.; Karathanasis, C.; Hanebutte, L.; Kilian, N.; Cyrklaff, M.; Heilemann, M.; Schwarz, U. S.; Kudryashev, M. et al.; Lanzer, M.: KAHRP dynamically relocalizes to remodeled actin junctions and associates with knob spirals in P. falciparum-infected erythrocytes. Molecular Microbiology (2021)

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Erdmann, P. S.; Hou, Z.; Klumpe, S.; Khavnekar, S.; Beck, F.; Wilfling, F.; Plitzko, J. M.; Baumeister, W.: In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli. Nature Communications 12 (1), 5364 (2021)

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Reggio, A.; Buonomo, V.; Berkane, R.; Bhaskara, R.; Tellechea, M.; Peluso, I.; Polishchuk, E.; Di Lorenzo, G.; Cirillov, C.; Esposito, M. et al.; Hussain, A.; Huebner, A. K.; Hübner, C. A.; Settembre, C.; Hummer, G.; Grumati, P.; Stolz, A.: Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control. EMBO Reports 22 (9), e52289 (2021)

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Watanabe, T.; Pfeil-Gardiner, O.; Kahnt, J.; Koch, J.; Shima, S.; Murphy, B. J.: Three-megadalton complex of methanogenic electron-bifurcating and CO₂-fixing enzymes. Science 373 (6559), pp. 1151 - 1156 (2021)

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Safarian, S.; Opel-Reading, H. K.; Wu, D.; Mehdipour, A. R.; Hards, K.; Harold, L. H.; Radloff, M.; Stewart, I.; Welsch, S.; Hummer, G. et al.; Cook, G. M.; Krause, K. L.; Michel, H.: The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB. Nature Communications 12 (1), 5236 (2021)

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Chicano, T. M.; Dietrich, L.; de Almeida, N. M.; Akram, M.; Hartmann, E.; Leidreiter, F.; Leopoldus, D.; Mueller, M.; Sanchez, R. M.; Nuijten, G. H. L. et al.; Reimann, J.; Seifert, K.-A.; Schlichting, I.; van Niftrik, L.; Jetten, M. S. M.; Dietl, A.; Kartal, B.; Parey, K.; Barends, T. R. M.: Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex. Nature Microbiology 6 (9), pp. 1129 - 1139 (2021)

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Falkner, S.; Schwierz, N.: Kinetic pathways of water exchange in the first hydration shell of magnesium: Influence of water model and ionic force field. The Journal of Chemical Physics 155 (8), 084503 (2021)

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Desch, K.; Langer, J. D.; Schuman, E. M.: Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling. Cell Reports 36 (8), 109583 (2021)

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Sabinina, V. J.; Hossain, M. J.; Hériché, J.-K.; Hoess, P.; Nijmeijer, B.; Mosalaganti, S.; Kueblbeck, M.; Callegari, A.; Szymborska, A.; Beck, M. et al.; Ries, J.; Ellenberg, J.: Three-dimensional superresolution fluorescence microscopy maps the variable molecular architecture of the nuclear pore complex. Molecular Biology of the Cell 32 (17), pp. 1523 - 1533 (2021)

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Väth, K.; Mattes, C.; Reinhard, J.; Covino, R.; Stumpf, H.; Hummer, G.; Ernst, R.: Cysteine cross-linking in native membranes establishes the transmembrane architecture of Ire1. The Journal of Cell Biology 220 (8), e202011078 (2021)

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Mukherjee, R.; Bhattacharya, A.; Bojkova, D.; Mehdipour, A. R.; Shin, D.; Khan, K. S.; Hei-Yin Cheung, H.; Wong, K.-B.; Ng, W.; Cinatl, J. et al.; Geurink, P. P.; van der Heden van Noort, G. J.; Rajalingam, K.; Ciesek, S.; Hummer, G.; Dikic, I.: Famotidine inhibits Toll-like receptor 3-mediated inflammatory signaling in SARS-CoV2 infection. The Journal of Biological Chemistry 297 (2), 100925 (2021)

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Nikolaev, A.; Safarian, S.; Thesseling, A.; Wohlwend, D.; Friedrich, T.; Michel, H.; Kusumoto, T.; Sakamoto, J.; Melin, F.; Hellwig, P.: Electrocatalytic evidence of the diversity of the oxygen reaction in the bacterial bd oxidase from different organisms. Biochimica et Biophysica Acta, Bioenergetics 1862 (8), e148436 (2021)

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Kanavaki, I.; Drakonaki, A.; Geladas, E. D.; Spyros, A.; Xie, H.; Tsiotis, G.: Polyhydroxyalkanoate (PHA) Production in Pseudomonas sp. phDV1 Strain Grown on Phenol as Carbon Sources. Microorganisms 9 (8), 1636 (2021)

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Schumacher, M.; Klare, J. P.; Bamann, C.; Steinhoff, H.-J.: DEER Spectroscopy of Channelrhodopsin-2 Helix B Movements in Trapped Photocycle Intermediates. Applied Magnetic Resonance (2021)

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Schaefer, S. L.; Jung, H.; Hummer, G.: Binding of SARS-CoV-2 Fusion Peptide to Host Endosome and Plasma Membrane. The Journal of Physical Chemistry B 125 (28), pp. 7732 - 7741 (2021)

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Becker-Baldus, J.; Leeder, A.; Brown, L. J.; Brown, R. C. D.; Bamann, C.; Glaubitz, C.: The Desensitized Channelrhodopsin-2 Photointermediate Contains 13 -cis, 15 -syn Retinal Schiff Base. Angewandte Chemie, International Edition in English 60 (30), pp. 16442 - 16447 (2021)

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Journal Article

Armstrong, L. A.; Lange, S. M.; Dee Cesare, V.; Matthews, S. P.; Nirujogi, R. S.; Cole, I.; Hope, A.; Cunningham, F.; Toth, R.; Mukherjee, R. et al.; Bojkova, D.; Gruber, F.; Gray, D.; Wyatt, P. G.; Cinatl, J.; Đikić, I.; Davies, P.; Kulathu, Y.: Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies. PLoS One 16 (7), e0253364 (2021)

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Kannt, A.; Đikić, I.: Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation. Cell Chemical Biology 28 (7), pp. 1014 - 1031 (2021)

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Giraldo-Barreto, J.; Ortiz, S.; Thiede, E. H.; Palacio-Rodriguez, K.; Carpenter, B.; Barnett, A. H.; Cossio, P.: A Bayesian approach to extracting free-energy profiles from cryo-electron microscopy experiments. Scientific Reports 11 (1), 13657 (2021)

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Zabelskii, D.; Dmitrieva, N.; Volkov, O.; Shevchenko, V.; Kovalev, K.; Balandin, T.; Soloviov, D.; Astashkin, R.; Zinovev, E.; Alekseev, A. et al.; Round, E.; Polovinkin, V.; Chizhov, I.; Rogachev, A.; Okhrimenko, I.; Borshchevskiy, V.; Chupin, V.; Büldt, G.; Yutin, N.; Bamberg, E.; Koonin, E.; Gordeliy, V.: Structure-based insights into evolution of rhodopsins. Communications Biology 4 (1), 821 (2021)

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Journal Article

Feyh, R.; Waeber, N. B.; Prinz, S.; Giammarinaro, P. I.; Bange, G.; Hochberg, G.; Hartmann, R. K.; Altegoer, F.: Structure and mechanistic features of the prokaryotic minimal RNase P. eLife 10, e70160 (2021)

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Journal Article

Bullerjahn, J. T.; Hummer, G.: Maximum likelihood estimates of diffusion coefficients from single-particle tracking experiments. The Journal of Chemical Physics 154 (23), 234105 (2021)

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Zhu, G.; Zeng, H.; Zhang, S.; Juli, J.; Tai, L.; Zhang, D.; Pang , X.; Zhang, Y.; Lam, S. M.; Zhu, Y. et al.; Peng, G.; Michel, H.; Sun, F.: The unusual homodimer of a heme‐copper terminal oxidase allows itself to utilize two electron donors. Angewandte Chemie, International Edition in English 60 (24), pp. 13323 - 13330 (2021)

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Journal Article

Dijkman, P. M.; Marzluf, T.; Zhang, Y.; Chang, S.-Y. S.; Helm, D.; Lanzer, M.; Bujard, H.; Kudryashev, M.: Structure of the merozoite surface protein 1 from Plasmodium falciparum. Science Advances 7 (23), eabg0465 (2021)

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Klusch, N.; Senkler, J.; Yildiz, Ö.; Kühlbrandt, W.; Braun, H.-P.: A ferredoxin bridge connects the two arms of plant mitochondrial complex I. The Plant Cell 33 (6), pp. 2072 - 2091 (2021)

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Mehdipour, A. R.; Hummer, G.: Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike. Proceedings of the National Academy of Sciences of the United States of America 118 (19), e2100425118 (2021)

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Journal Article

Ho, N. T.; Siggel, M.; Camacho, K. V.; Bhaskara, R.; Hicks, J. M.; Yao, Y.-C.; Zhang, Y.; Köfinger, J.; Hummer, G.; Noy, A.: Membrane fusion and drug delivery with carbon nanotube porins. Proceedings of the National Academy of Sciences of the United States of America 118 (19), e2016974118 (2021)

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Journal Article

Cruz-León, S.; Grotz, K. K.; Schwierz, N.: Extended magnesium and calcium force field parameters for accurate ion–nucleic acid interactions in biomolecular simulations. The Journal of Chemical Physics 154 (17), 171102 (2021)

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Staritzbichler, R.; Sarti, E.; Yaklich, E.; Aleksandrova, A.; Stamm, M.; Khafizov, K.; Forrest, L. R.: Refining pairwise sequence alignments of membrane proteins by the incorporation of anchors. plos one 16 (4), e0239881 (2021)

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Floris, D.; Kühlbrandt, W.: Molecular landscape of etioplast inner membranes in higher plants. Nature Plants 7 (4), pp. 514 - 523 (2021)

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Kayastha, K.; Vitt, S.; Buckel, W.; Ermler, U.: Flavins in the electron bifurcation process. Archives of Biochemistry and Biophysics 701, 108796 (2021)

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Grotz, K. K.; Cruz-León, S.; Schwierz, N.: Optimized Magnesium Force Field Parameters for Biomolecular Simulations with Accurate Solvation, Ion-Binding, and Water-Exchange Properties. Journal of Chemical Theory and Computation 17 (4), pp. 2530 - 2540 (2021)

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Nome, R. A.; Cossio, P.; Z, Y.: Editorial: Integrating Timescales From Molecules Up. Frontiers in Chemistry 9, 680533 (2021)

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Journal Article

Zabret, J.; Bohn, S.; Schuller, S. K.; Arnolds, O.; Möller, M.; Meier-Credo, J.; Liauw, P.; Chan, A.; Tajkhorshid, E.; Langer, J. D. et al.; Stoll, R.; Krieger-Liszkay, A.; Engel, B. D.; Rudack , T.; Schuller, J. M.; Nowaczyk , M. M.: Structural insights into photosystem II assembly. Nature Plants 7, pp. 524 - 538 (2021)

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Journal Article

Appel, L.; Willistein, M.; Dahl, C.; Ermler, U.; Boll, M.: Functional diversity of prokaryotic HdrA(BC) modules: Role in flavin-based electron bifurcation processes and beyond. Biochimica et Biophysica Acta, Bioenergetics 1862 (4), 148379 (2021)

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Journal Article

Gubas, A.; Karantanou, C.; Popovic, D.; Tascher, G.; Hoffmann, M. E.; Platzek, A.; Dawe, N.; Dikic, I.; Krause, D. S.; McEwan, D. G.: The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways. FEBS Letters 595 (7), pp. 864 - 880 (2021)

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Sikora, M.; von Bülow, S.; Blanc, F. E. C.; Gecht, M.; Covino, R.; Hummer, G.: Computational epitope map of SARS-CoV-2 spike protein. PLoS Computational Biology 17 (4), e1008790 (2021)

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Journal Article

Ochoa, R.; Laskowski, R. A.; Thornton, J. M.; Cossio, P.: Impact of Structural Observables From Simulations to Predict the Effect of Single-Point Mutations in MHC Class II Peptide Binders. Frontiers in Molecular Biosciences 8, 636562 (2021)

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Gubas, A.; Đikić, I.: A Guide To… The regulation of selective autophagy receptors. The FEBS Journal 288, pp. 1 - 15 (2021)

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Ochoa, R.; Cossio, P.: PepFun: Open Source Protocols for Peptide-Related Computational Analysis. Molecules 26 (6), 1664 (2021)

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Journal Article

Jakdetchai, O.; Eberhardt, P.; Asido, M.; Kaur, J.; Kriebel, C. N.; Mao, J.; Leeder, A. J.; Brown, L. J.; Brown, R. C. D.; Becker-Baldus, J. et al.; Bamann, C.; Wachtveitl, J.; Glaubitz, C.: Probing the photointermediates of light-driven sodium ion pump KR2 by DNP-enhanced solid-state NMR. Science Advances 7 (11), eabf4213 (2021)

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D'Imprima, E.; Kühlbrandt, W.: Current limitations to high-resolution structure determination by single-particle cryoEM. Quarterly Reviews of Biophysics 54, e4 (2021)

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Journal Article

Berger, C.; Ravelli, R. B. G.; López-Iglesias, C.; Kudryashev, M.; Diepold, A.; Peters, P. J.: Structure of the Yersinia injectisome in intracellular host cell phagosomes revealed by cryo FIB electron tomography. Journal of Structural Biology 213 (1), 107701 (2021)

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Ernst, C.; Kayastha, K.; Koch , T.; Venceslau, S. S.; Pereira, I. A.C.; Demmer, U.; Ermler, U.; Dahl, C.: Structural and spectroscopic characterization of a HdrA‐like subunit from Hyphomicrobium denitrificans. The FEBS Journal 288 (5), pp. 1664 - 1678 (2021)

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Wiefering, J.-P.; Mills, D. J.; Kühlbrandt, W.: Devitrification reduces beam-induced movement in cryo-EM. IUCrJ 8 (Pt 2), pp. 186 - 194 (2021)

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Journal Article

Siggel, M.; Bhaskara, R.; Moesser, M. K.; Đikić, I.; Hummer, G.: FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes. The Journal of Physical Chemistry Letters 12 (7), pp. 1926 - 1931 (2021)

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Gorgulla, C.; Padmanabha Das, K. M.; Leigh, K. E.; Cespugli, M.; Fischer, P. D.; Wang, Z.-F.; Tesseyre, G.; Pandita, S.; Shnapir, A.; Calderaio, A. et al.; Gechev, M.; Rose, A.; Lewis, N.; Hutcheson, C.; Yaffe, E.; Luxenburg, R.; Herce, H. D.; Durmaz, V.; Halazonetis, T. D.; Fackeldey, K.; Patten, J. J.; Chuprina, A.; Dziuba, I.; Plekhova, A.; Moroz, Y.; Radchenko, D.; Tarkhanova, O.; Yavnyuk, I.; Gruber, C.; Yust, R.; Payne, D.; Näär, A. M.; Namchuk, M. N.; Davey, R. A.; Wagner, G.; Kinney, J.; Arthanari, H.: A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening. iScience 24 (2), 102021 (2021)

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Zila, V.; Margiotta, E.; Turoňová, B.; Müller, T. G.; Zimmerli, C. E.; Mattei, S.; Allegretti, M.; Börner, K.; Rada, J.; Müller, B. et al.; Lusic, M.; Kräusslich, H.-G.; Beck, M.: Cone-shaped HIV-1 capsids are transported through intact nuclear pores. Cell 184 (4), pp. 1032 - 1046 (2021)

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Zhang, Y.; Dijkman, P. M.; Zou, R.; Zandl-Lang, M.; Sanchez, R. M.; Eckhardt-Strelau, L.; Köfeler, H.; Vogel, H.; Yuan, S.; Kudryashev, M.: Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers. Nature Communications 12 (1), 1074 (2021)

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Journal Article

Eberhardt, P.; Slavov, C.; Sörmann, J.; Bamann, C.; Braun, M.; Wachtveitl, J.: Temperature Dependence of the Krokinobacter rhodopsin 2 Kinetics. Biophysical Journal (Annual Meeting Abstracts) 120 (3), pp. 568 - 575 (2021)

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Riedel, R.; Frese, N.; Yang, F.; Wortmann, M.; Dalpke, R.; Rhinow, D.; Hampp, N.; Gölzhäuser, A.: Fusion of purple membranes triggered by immobilization on carbon nanomembranes. Beilstein Journal of Nanotechnology 12, pp. 93 - 101 (2021)

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Journal Article

Benayad, Z.; von Bülow, S.; Stelzl, L. S.; Hummer, G.: Simulation of FUS Protein Condensates with an Adapted Coarse-Grained Model. Journal of Chemical Theory and Computation 17 (1), pp. 525 - 537 (2021)

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Tiku, V.; Kofoed, E. M.; Yan, D.; Kang, J.; Xu, M.; Reichelt, M.; Dikic, I.; Tan, M.-W.: Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii. Scientific Reports 11 (1), 618 (2021)

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Cunha, E. S.; Chen, X.; Sanz-Gaitero, M.; Mills, D. J.; Luecke, H.: Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution. Nature Communications 12 (1), 230 (2021)

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Mills, D. J.: Setting up and operating a cryo-EM laboratory. Quarterly Reviews of Biophysics 54, e2 (2021)

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Ross, A. B.; Langer, J. D.; Jovanovic, M.: Proteome Turnover in the Spotlight: Approaches, Applications, and Perspectives. Molecular and Cellular Proteomics 20, 100016 (2021)

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Bárcena, M.; Barnes, C. O.; Beck, M.; Bjorkman, P. J.; Canard, B.; Gao, G. F.; Gao, Y.; Hilgenfeld, R.; Hummer, G.; Patwardhan, A. et al.; Santoni, G.; Saphire, E. O.; Schaffitzel, C.; Schendel, S. L.; Smith, J. L.; Thorn, A.; Veesler, D.; Zhang, P.; Zhou, Q.: Structural biology in the fight against COVID-19. Nature Structural and Molecular Biology 28 (1), pp. 2 - 7 (2021)

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Klionsky, D. J.; Abdel-Aziz, A. K.; Abdelfatah, S.; Hummer, G.; 2295 other, A.: Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17 (1), pp. 1 - 382 (2021)

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Lyratzakis, A.; Valsamidis, G.; Kanavaki, I.; Nikolaki , A.; Rupprecht, F. A.; Langer, J. D.; Tsiotis, G.: Proteomic Characterization of the Pseudomonas sp. Strain phDV1 Response to Monocyclic Aromatic Compounds. Proteomics 21 (2), e2000003 (2021)

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Wells, C. I.; Al-Ali, H.; Andrews, D. M.; Asquith, C. R. M.; Axtman, A. D.; Dikic, I.; Ebner, D.; Ettmayer, P.; Fischer, C.; Frederiksen, M. et al.; Futrell, R. E.; Gray, N. S.; Hatch, S. B.; Knapp, S.; Lücking, U.; Michaelides, M.; Mills, C. E.; Müller, S.; Owen, D.; Picado, A.; Saikatendu, K. S.; Schröder, M.; Stolz, A.; Tellechea, M.; Turunen, B. J.; Vilar, S.; Wang, J.; Zuercher, W. J.; Willson, T. M.; Drewry, D. H.: The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. International Journal of Molecular Sciences 22 (2), 566 (2021)

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2020

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Ochoa, R.; Magnitov, M.; Laskowski, R. A.; Cossio, P.; Thornton, J. M.: An automated protocol for modelling peptide substrates to proteases. BMC Bioinformatics 21 (1), 586 (2020)

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Ebenhoch, R.; Prinz, S.; Kaltwasser, S.; Mills, D. J.; Meinecke, R.; Rübbelke, M.; Reinert, D.; Bauer, M.; Weixler, L.; Zeeb, M. et al.; Vonck, J.; Nar, H.: A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proceedings of the National Academy of Sciences of the United States of America 117 (50), pp. 31838 - 31849 (2020)

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Collauto, A.; von Bülow, S.; Gophane, D.; Saha, S.; Stelzl, L. S.; Hummer, G.; Sigurdsson, S. T.; Prisner, T.: Compaction of RNA duplexes in the cell. Angewandte Chemie, International Edition in English 59, pp. 23025 - 23029 (2020)

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Oda, K.; Lee, Y.; Wiriyasermkul, P.; Tanaka, Y.; Takemoto, M.; Yamashita, K.; Nagamori, S.; Nishizawa, T.; Nureki, O.: Consensus mutagenesis approach improves the thermal stability of system x_c- transporter, xCT, and enables cryo-EM analyses. Protein Science 29, pp. 2398 - 2407 (2020)

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Yadav, S.; Centola, M.; Yildiz, Ö.; Pogoryelov, D.; Rai, L. C.; Schleiff, E.: Purification and Preliminary X-Ray Crystallographic Analysis of the Peptidyl-Prolyl cis-trans Isomerase Alr5059 from Anabaena sp. PCC 7120. Crystallography Reports 65 (7), pp. 1226 - 1230 (2020)

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Galemou Yoga, E.; Parey, K.; Djurabekova, A.; Haapanen, O.; Siegmund, K.; Zwicker, K.; Sharma, V.; Zickermann, V.; Angerer, H.: Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I. Nature Communications 11, 6008 (2020)

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Shin, D.; Mukherjee, R.; Grewe, D.; Bojkova, D.; Baek, K.; Bhattacharya, A.; Schulz, L.; Widera, M.; Mehdipour, A. R.; Tascher, G. et al.; Geurink, P. P.; Wilhelm, A.; van der Heden van Noort, G. J.; Ovaa, H.; Müller, S.; Knobeloch, K.-P.; Rajalingam, K.; Schulman, B.; Cinatl, J.; Hummer, G.; Ciesek, S.; Đikić, I.: Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 587 (7835), pp. 657 - 662 (2020)

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Shin, D.; Bhattacharya, A.; Cheng, Y.-L.; Alonso, M. C.; Mehdipour, A. R.; van der Heden van Noort, G. J.; Ovaa, H.; Hummer, G.; Dikic, I.: Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection. eLife 9 (2020)

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Zabelskii, D.; Alekseev, A.; Kovalev, K.; Rankovic, V.; Balandin, T.; Soloviov, D.; Bratanov, D.; Savelyeva, E.; Podolyak, E.; Volkov, D. et al.; Vaganova, S.; Astashkin, R.; Chizhov, I.; Yutin, N.; Rulev, M.; Popov, A.; Eria-Oliveira, A.-S.; Rokitskaya, T.; Mager, T.; Antonenko, Y.; Rosselli, R.; Armeev, G.; Shaitan, K.; Vivaudou, M.; Büldt, G.; Rogachev, A.; Rodriguez-Valera, F.; Kirpichnikov, M.; Moser, T.; Offenhäusser, A.; Willbold, D.; Koonin, E.; Bamberg, E.; Gordeliy, V.: Viral rhodopsins 1 are an unique family of light-gated cation channels. Nature Communications 11, 5707 (2020)

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Müller, D. J.; Dumitru, A. C.; Lo Giudice, C.; Gaub, H. E.; Hinterdorfer, P.; Hummer, G.; De Yoreo, J. J.; Dufrêne, Y. F.; Alsteens, D.: Atomic Force Microscopy-Based Force Spectroscopy and Multiparametric Imaging of Biomolecular and Cellular Systems. Chemical Reviews (2020)

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Januliene, D.; Moeller, A.: Cryo-EM of ABC transporters: an ice-cold solution to everything? FEBS Letters 594, pp. 3776 - 3789 (2020)

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Schulte, L.; Mao, J.; Reitz, J.; Sreeramulu, S.; Kudlinzki, D.; Hodirnau, V.-V.; Meier-Credo, J.; Saxena, K.; Buhr, F.; Langer, J. D. et al.; Blackledge, M.; Frangakis, A. S.; Glaubitz, C.; Schwalbe, H.: Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. Nature Communications 11 (1), 5569 (2020)

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Sikora, M.; Ermel, U. H.; Seybold, A.; Kunz, M.; Calloni, G.; Reitz, J.; Vabulas, R. M.; Hummer, G.; Frangakis, A. S.: Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography. Proceedings of the National Academy of Sciences of the United States of America 117 (44), pp. 27132 - 27140 (2020)

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Golubev, A.; Fatkhullin, B.; Khusainov, I.; Jenner, L.; Gabdulkhakov, A.; Validov, S.; Yusupova, G.; Yusupov, M.; Usachev, K.: Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution. FEBS Letters 594 (21), pp. 3551 - 3567 (2020)

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Ngo, G.; Centola, M.; Krasnoselska, G.; Pogoryelov, D.; Yildiz, Ö.; Schleiff, E.: LptC from Anabaena sp. PCC 7120: Expression, purification and crystallization. Protein Expression and Purification 175, 105689 (2020)

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Allegretti, M.; Zimmerli, C. E.; Rantos, V.; Wilfling, F.; Ronchi, P.; Fung, H. K. H.; Lee, C.-W.; Hagen, W.; Turoňová, B.; Karius, K. et al.; Börmel, M.; Zhang, X.; Müller, C. W.; Schwab, Y.; Mahamid, J.; Pfander, B.; Kosinski, J.; Beck, M.: In-cell architecture of the nuclear pore and snapshots of its turnover. Nature 586 (7831), pp. 796 - 800 (2020)

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Chowdhury, N. P.; Alberti, L.; Linder, M.; Müller, V.: Exploring Bacterial Microcompartments in the Acetogenic Bacterium Acetobacterium woodii. Frontiers in Microbiology 11, 593467 (2020)

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Turoňová, B.; Sikora, M.; Schürmann, C.; Hagen, W. J. H.; Welsch, S.; Blanc, F. E. C.; von Bülow, S.; Gecht, M.; Bagola, K.; Hörner, C. et al.; van Zandbergen, G.; Landry, J.; de Azevedo, N. T. D.; Mosalaganti, S.; Schwarz, A.; Covino, R.; Mühlebach, M. D.; Hummer, G.; Krijnse Locker, J.; Beck, M.: In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges. Science 370 (6513), pp. 203 - 208 (2020)

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Gebel, J.; Tuppi, M.; Chaikuad, A.; Hötte, K.; Schröder, M.; Schulz, L.; Löhr, F.; Gutfreund, N.; Finke, F.; Henrich, E. et al.; Mezhyrova, J.; Lehnert, R.; Pampaloni, F.; Hummer, G.; Stelzer, E. H.K.; Knapp, S.; Dötsch, V.: p63 uses a switch-like mechanism to set the threshold for induction of apoptosis. Nature Chemical Biology 16 (10), pp. 1078 - 1086 (2020)

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Gecht, M.; Siggel, M.; Linke, M.; Hummer, G.; Köfinger, J.: MDBenchmark: A toolkit to optimize the performance of molecular dynamics simulations. The Journal of Chemical Physics 153 (14), 144105 (2020)

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Gewering, T.; Möller, A.: Neue Möglichkeiten für die Strukturbestimmung von Membranproteinen. Biospektrum 26 (6), pp. 615 - 617 (2020)

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Lans, I.; Palacio-Rodríguez, K.; Cavasotto, C. N.; Cossio, P.: Flexi-pharma: a molecule-ranking strategy for virtual screening using pharmacophores from ligand-free conformational ensembles. Journal of Computer-Aided Molecular Design 34 (10), pp. 1063 - 1077 (2020)

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Shvarev, D.: Kryo-EM-Einzelpartikelanalyse eines Membrantransporters in Liposomen. Biospektrum 26, p. 650 - 650 (2020)

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Bayer, N. J.; Januliene, D.; Zocher, G.; Stehle, T.; Möller, A.; Blaum, B. S.: Structure of Merkel cell polyomavirus capsid and interaction with its glycosaminoglycan attachment receptor. Journal of Virology 94 (20), e01664-19 (2020)

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Psaroulaki, A.; Mathioudaki, E.; Vranakis, I.; Chochlakis, D.; Yachnakis, E.; Kokkini , S.; Xie, H.; Tsiotis, G.: In the Search of Potential Serodiagnostic Proteins to Discriminate Between Acute and Chronic Q Fever in Humans. Some Promising Outcomes. Frontiers in Cellular and Infection Microbiology 10, 557027 (2020)

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Buczak, K.; Kirkpatrick, J. M.; Truckenmueller, F.; Santinha, D.; Ferreira, L.; Roessler, S.; Singer, S.; Beck, M.; Ori, A.: Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry. Nature Protocols 15 (9), pp. 2956 - 2979 (2020)

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Mykuliak, V. V.; Sikora, M.; Booth, J. J.; Cieplak, M.; Shalashilin, D. V.; Hytönen, V. P.: Mechanical Unfolding of Proteins - A Comparative Nonequilibrium Molecular Dynamics Study. Biophysical Journal 119, pp. 939 - 949 (2020)

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Sawa-Makarska, J.; Baumann, V.; Coudevylle, N.; von Bülow, S.; Nogellova, V.; Abert, C.; Schuschnig, M.; Graef, M.; Hummer, G.; Martens, S.: Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation. Science 369 (6508), eaaz7714 (2020)

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Wu, D.; Grund, T. N.; Welsch, S.; Mills, D.; Michel, M.; Safarian, S.; Michel, H.: Structural basis for amino acid exchange by a human heteromeric amino acid transporter. Proceedings of the National Academy of Sciences of the United States of America 117 (35), 202008111, pp. 21281 - 21287 (2020)

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Reyer, A.; Häßler, M.; Scherzer, S.; Huang, S.; Pedersen, J. T.; Al-Rascheid, K. A. S.; Bamberg, E.; Palmgren, M.; Dreyer, I.; Nagel, G. et al.; Hedrich, R.; Becker, D.: Channelrhodopsin-mediated optogenetics highlights a central role of depolarization-dependent plant proton pumps. Proceedings of the National Academy of Sciences of the United States of America 117 (34), pp. 20920 - 20925 (2020)

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Scherr, J.; Tang, Z.; Küllmer, M.; Balser, S.; Scholz, A. S.; Winter, A.; Parey, K.; Rittner, A.; Grininger, M.; Zickermann, V. et al.; Rhinow, D.; Terfort, A.; Turchanin, A.: Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy. ACS Nano 14 (8), pp. 9972 - 9978 (2020)

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Lans, I.; Anoz-Carbonell, E.; Palacio-Rodríguez, K.; Aínsa, J. A.; Medina, M.; Cossio, P.: In silico discovery and biological validation of ligands of FAD synthase, a promising new antimicrobial target. PLoS Computational Biology 16 (8), e1007898 (2020)

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