Publications of the Emeritus Department of Biophysical Chemistry

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Journal Article (33)

2015
Journal Article
Koshy, C.; Ziegler, C.: Structural insights into functional lipid–protein interactions in secondary transporters. Biochimica et Biophysica Acta (BBA) - General Subjects 1850 (3), pp. 476 - 487 (2015)
Journal Article
Schweikhard, E. S.; Burckhardt, B. C.; Joos, F.; Fenollar-Ferrer, C.; Forrest, L. R.; Kempson, S. A.; Ziegler, C.: Role of N-glycosylation in renal betaine transport. Biochemical Journal 470 (2), pp. 169 - 179 (2015)
Journal Article
Spindler, P. E.; Waclawska, I.; Endeward, B.; Plackmeyer, J.; Ziegler, C.; Prisner, T. F.: Carr−Purcell Pulsed Electron Double Resonance with Shaped Inversion Pulses. The Journal of Physical Chemistry 6 (21), pp. 4331 - 4335 (2015)
2014
Journal Article
Perez, C.; Faust, B.; Mehdipour, A. R.; Francesconi, K. A.; Forrest, L. R.; Ziegler, C.: Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling. Nature Communications 5, 4231 (2014)
Journal Article
Keller, R.; Ziegler, C.; Schneider, D.: When two turn into one: evolution of membrane transporters from half modules. Biological Chemistry 395 (12), pp. 1379 - 1388 (2014)
Journal Article
Sand, M.; Stahl, J.; Waclawska, I.; Ziegler, C.; Averhoff, B.: Identification of an osmo-dependent and an osmo-independent choline transporter in Acinetobacter baylyi: implications in osmostress protection and metabolic adaptation. Environmental Microbiology 16 (6), pp. 1490 - 1502 (2014)
Journal Article
Schweikhard, E. S.; Kempson, S. A.; Ziegler, C.; Burckhardt, B. C.: Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress. American Journal of Physiology - Renal Physiology 307 (1), pp. F107 - F115 (2014)
2013
Journal Article
Korkmaz, F.; Ressl, S.; Ziegler, C.; Mäntele, W.: K+-induced conformational changes in the trimeric betaine transporter BetP monitored by ATR-FTIR spectroscopy. Biochimica et Biophysica Acta 1828 (4), pp. 1181 - 1191 (2013)
Journal Article
Koshy, C.; Schweikhard, E. S.; Gärtner, R. M.; Perez, C.; Yildiz, Ö.; Ziegler, C.: Structural evidence for functional lipid interactions in the betaine transporter BetP. The EMBO Journal 32 (23), pp. 3096 - 3105 (2013)
Journal Article
Perez, C.; Ziegler, C.: Mechanistic aspects of sodium-binding sites in LeuT-like fold symporters. Biological Chemistry 394 (5), pp. 641 - 648 (2013)
2012
Journal Article
Khafizov, K.; Perez, C.; Koshy, C.; Quick, M.; Fendler, K.; Ziegler, C.; Forrest, L. R.: Investigation of the sodium binding sites in the betaine transporter BetP. Proceedings of the National Academy of Sciences of the Untited States of America 109 (44), pp. 17754 - 17755 (2012)
Journal Article
Perez, C.; Koshy, C.; Yildiz, Ö.; Ziegler, C.: Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP. Nature 490, pp. 126 - 130 (2012)
Journal Article
Schweikhard, E. S.; Ziegler, C. M.: Chapter One – Amino Acid Secondary Transporters: Toward a Common Transport Mechanism. Current Topics in Membranes 70, pp. 1 - 28 (2012)
2011
Journal Article
Marinelli, F.; Kuhlmann, S. I.; Grell, E.; Kunte, H.-J.; Ziegler, C.; Faraldo-Gómez, J. D.: Evidence for an allosteric mechanism of substrate release from membrane-transporter accessory binding proteins. Proceedings of the National Academy of Sciences of the United States of America 108 (49), pp. E1285 - E1292 (2011)
Journal Article
Forrest, L. R.; Krämer, R.; Ziegler, C.: The structural basis of secondary active transport mechanisms. Biochimica et Biophysica Acta - Bioenergetics 1807 (2), pp. 167 - 188 (2011)
Journal Article
Gärtner, R. M.; Perez, C.; Koshy, C.; Ziegler, C.: Role of Bundle Helices in a Regulatory Crosstalk in the Trimeric Betaine Transporter BetP. Journal of Molecular Biology 414 (3), pp. 327 - 336 (2011)
Journal Article
Ge, L.; Perez, C.; Waclawska, I.; Ziegler, C.; Muller, D. J.: Locating an extracellular K+-dependent interaction site that modulates betaine-binding of the Na+-coupled betaine symporter BetP. Proceedings of the National Academy of Sciences of the USA 108 (43), pp. E890 - E898 (2011)
Journal Article
Perez, C.; Khafizov, K.; Forrest, L. R.; Krämer, R.; Ziegler, C.: The role of trimerization in the osmoregulated betaine transporter BetP. EMBO Reports 12 (8), pp. 804 - 810 (2011)
Journal Article
Perez, C.; Koshy, C.; Ressl, S.; Nicklisch, S.; Krämer, R.; Ziegler, C.: Substrate specificity and ion coupling in the Na+/betaine symporter BetP. EMBO Journal 30, pp. 1221 - 1229 (2011)
Journal Article
Tsai, C.-J.; Khafizov, K.; Hakulinen, J.; Forrest, L. R.; Krämer, R.; Kühlbrandt, W.; Ziegler, C.: Structural Asymmetry in a Trimeric Na+/Betaine Symporter, BetP, from Corynebacterium glutamicum. Journal of Molecular Biology 407 (3), pp. 368 - 381 (2011)
2010
Journal Article
Schweikhard, E. S.; Kuhlmann, S. I.; Kunte, H.-J.; Grammann, K.; Ziegler, C. M.: Structure and Function of the Universal Stress Protein TeaD and its Role in Regulating the Ectoine Transporter TeaABC of Halomonas elongata DSM 2581T. Biochemistry 49 (10), pp. 2194 - 2204 (2010)
Journal Article
Ziegler, C.; Bremer, E.; Krämer, R.: The BCCT family of carriers: from physiology to crystal structure. Molecular Microbiology 78 (1), pp. 13 - 34 (2010)
2009
Journal Article
Appel, M.; Hizlan, D.; Vinothkumar, K. R.; Ziegler, C.; Kühlbrandt, W.: Conformations of NhaA, the Na+/H+ Exchanger from Escherichia coli, in the pH-Activated and Ion-Translocating States. Journal of Molecular Biology 388, pp. 659 - 672 (2009)
Journal Article
Krämer, R.; Ziegler, C.: Minireview: Regulative interactions of the osmosensing C-terminal domain in the trimeric glycine betaine transporter BetP from Corynebacterium glutamicum. Biological Chemistry 390 (8), pp. 685 - 691 (2009)
Journal Article
Ressl, S.; Terwisscha van Scheltinga, A. C.; Vonrhein, C.; Ott, V.; Ziegler, C.: Molecular basis of transport and regulation in the Na+/betaine symporter BetP. Nature 458, pp. 47 - 52 (2009)
2008
Journal Article
Kuhlmann, S. I.; Terwisscha van Scheltinga, A. C.; Bienert, R.; Kunte, H.-J.; Ziegler, C.: 1.55 Å Structure of the Ectoine Binding Protein TeaA of the Osmoregulated TRAP-Transporter TeaABC from Halomonas elongata. Biochemistry 47 (36), pp. 9475 - 9485 (2008)
2007
Journal Article
Tsai, C.-J.; Ejsing, C. S.; Shevchenko, A.; Ziegler, C.: The role of lipids and salts in two-dimensional crystallization of the glycine–betaine transporter BetP from Corynebacterium glutamicum. Journal of Structural Biology 160 (3), pp. 275 - 286 (2007)
2006
Journal Article
Kedrov, A.; Janovjak, H.; Ziegler, C.; Kuhlbrandt, W.; Muller, D. J.: Observing Folding Pathways and Kinetics of a Single Sodium-proton Antiporter from Escherichia coli. Journal of Molecular Biology 355, pp. 2 - 8 (2006)
Journal Article
Kedrov, A.; Ziegler, C.; Muller, D. J.: Differentiating Ligand and Inhibitor Interactions of a Single Antiporter. Journal of Molecular Biology 362 (5), pp. 925 - 932 (2006)
2005
Journal Article
Kedrov, A.; Krieg, M.; Ziegler, C.; Kühlbrandt, W.; Muller, D.: Locating ligand binding and activation of a single antiporter. EMBO Reports 6 (7), pp. 668 - 674 (2005)
Journal Article
Tsai, C.-J.; Ziegler, C.: Structure Determination of Secondary Transport Proteins by Electron Crystallography: Two-Dimensional Crystallization of the Betaine Uptake System BetP. Journal of Molecular Microbiology and Biotechnology 10, pp. 197 - 207 (2005)
2004
Journal Article
Kedrov, A.; Ziegler, C.; Janovjak, H.; Kühlbrandt, W.; Müller, D. J.: Controlled Unfolding and Refolding of a Single Sodium-proton Antiporter using Atomic Force Microscopy. Journal of Molecular Biology (London) 340 (5), pp. 1143 - 1152 (2004)
Journal Article
Ziegler, C.; Morbach, S.; Schiller, D.; Krämer, R.; Tziatzios, R.; Schubert, D.; Kühlbrandt, W.: Projection Structure and Oligomeric State of the Osmoregulated Sodium/Glycine Betaine Symporter BetP of Corynebacterium glutamicum. Journal of Molecular Biology 337 (5), pp. 1137 - 1147 (2004)

Conference Paper (1)

2011
Conference Paper
Khafizov, K.; Perez, C.; Tsai, C.-J.; Ziegler, C.; Forrest, L. R.: Computational and Experimental Studies of Substrate Binding, Conformational Change and Importance of the Trimeric State in the Glycine Betaine Transporter BetP. Biophysical Journal 100 (3, Supplement 1), p. 132a - 132a (2011)
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