Publications of Christine Ziegler

Journal Article (33)

2015
Journal Article
Koshy, C.; Ziegler, C.: Structural insights into functional lipid–protein interactions in secondary transporters. Biochimica et Biophysica Acta (BBA) - General Subjects 1850 (3), pp. 476 - 487 (2015)
Journal Article
Schweikhard, E. S.; Burckhardt, B. C.; Joos, F.; Fenollar-Ferrer, C.; Forrest, L. R.; Kempson, S. A.; Ziegler, C.: Role of N-glycosylation in renal betaine transport. Biochemical Journal 470 (2), pp. 169 - 179 (2015)
Journal Article
Spindler, P. E.; Waclawska, I.; Endeward, B.; Plackmeyer, J.; Ziegler, C.; Prisner, T. F.: Carr−Purcell Pulsed Electron Double Resonance with Shaped Inversion Pulses. The Journal of Physical Chemistry 6 (21), pp. 4331 - 4335 (2015)
2014
Journal Article
Perez, C.; Faust, B.; Mehdipour, A. R.; Francesconi, K. A.; Forrest, L. R.; Ziegler, C.: Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling. Nature Communications 5, 4231 (2014)
Journal Article
Sand, M.; Stahl, J.; Waclawska, I.; Ziegler, C.; Averhoff, B.: Identification of an osmo-dependent and an osmo-independent choline transporter in Acinetobacter baylyi: implications in osmostress protection and metabolic adaptation. Environmental Microbiology 16 (6), pp. 1490 - 1502 (2014)
Journal Article
Keller, R.; Ziegler, C.; Schneider, D.: When two turn into one: evolution of membrane transporters from half modules. Biological Chemistry 395 (12), pp. 1379 - 1388 (2014)
Journal Article
Schweikhard, E. S.; Kempson, S. A.; Ziegler, C.; Burckhardt, B. C.: Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress. American Journal of Physiology - Renal Physiology 307 (1), pp. F107 - F115 (2014)
2013
Journal Article
Koshy, C.; Schweikhard, E. S.; Gärtner, R. M.; Perez, C.; Yildiz, Ö.; Ziegler, C.: Structural evidence for functional lipid interactions in the betaine transporter BetP. The EMBO Journal 32 (23), pp. 3096 - 3105 (2013)
Journal Article
Perez, C.; Ziegler, C.: Mechanistic aspects of sodium-binding sites in LeuT-like fold symporters. Biological Chemistry 394 (5), pp. 641 - 648 (2013)
Journal Article
Korkmaz, F.; Ressl, S.; Ziegler, C.; Mäntele, W.: K+-induced conformational changes in the trimeric betaine transporter BetP monitored by ATR-FTIR spectroscopy. Biochimica et Biophysica Acta-Biomembranes 1828 (4), pp. 1181 - 1191 (2013)
2012
Journal Article
Khafizov, K.; Perez, C.; Koshy, C.; Quick, M.; Fendler, K.; Ziegler, C.; Forrest, L. R.: Investigation of the sodium binding sites in the betaine transporter BetP. Proceedings of the National Academy of Sciences of the United States of America 109 (44), pp. E3035 - E3045 (2012)
Journal Article
Perez, C.; Koshy, C.; Yildiz, Ö.; Ziegler, C.: Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP. Nature 490, pp. 126 - 130 (2012)
Journal Article
Schweikhard, E. S.; Ziegler, C. M.: Chapter One – Amino Acid Secondary Transporters: Toward a Common Transport Mechanism. Current Topics in Membranes 70, pp. 1 - 28 (2012)
2011
Journal Article
Marinelli, F.; Kuhlmann, S.; Grell, E.; Kunte, H.-J.; Ziegler, C.; Faraldo-Gómez, J. D.: Evidence for an allosteric mechanism of substrate release from membrane-transporter accessory binding proteins. Proceedings of the National Academy of Sciences of the United States of America 108 (49), pp. E1285 - E1292 (2011)
Journal Article
Gärtner, R. M.; Perez, C.; Koshy, C.; Ziegler, C.: Role of Bundle Helices in a Regulatory Crosstalk in the Trimeric Betaine Transporter BetP. Journal of Molecular Biology 414 (3), pp. 327 - 336 (2011)
Journal Article
Ge, L.; Perez, C.; Waclawska, I.; Ziegler, C.; Muller, D. J.: Locating an extracellular K+-dependent interaction site that modulates betaine-binding of the Na+-coupled betaine symporter BetP. Proceedings of the National Academy of Sciences of the United States of America 108 (43), pp. E890 - E898 (2011)
Journal Article
Perez, C.; Khafizov, K.; Forrest, L. R.; Krämer, R.; Ziegler, C.: The role of trimerization in the osmoregulated betaine transporter BetP. EMBO Reports 12 (8), pp. 804 - 810 (2011)
Journal Article
Perez, C.; Koshy, C.; Ressl, S.; Nicklisch, S.; Krämer, R.; Ziegler, C.: Substrate specificity and ion coupling in the Na+/betaine symporter BetP. EMBO Journal 30, pp. 1221 - 1229 (2011)
Journal Article
Tsai, C.-J.; Khafizov, K.; Hakulinen, J.; Forrest, L. R.; Krämer, R.; Kühlbrandt, W.; Ziegler, C.: Structural Asymmetry in a Trimeric Na+/Betaine Symporter, BetP, from Corynebacterium glutamicum. Journal of Molecular Biology 407 (3), pp. 368 - 381 (2011)
Journal Article
Forrest, L. R.; Krämer, R.; Ziegler, C.: The structural basis of secondary active transport mechanisms. Biochimica et Biophysica Acta, Bioenergetics 1807 (2), pp. 167 - 188 (2011)
2010
Journal Article
Ziegler, C.; Bremer, E.; Krämer, R.: The BCCT family of carriers: from physiology to crystal structure. Molecular Microbiology 78 (1), pp. 13 - 34 (2010)
Journal Article
Schweikhard, E. S.; Kuhlmann, S. I.; Kunte, H.-J.; Grammann, K.; Ziegler, C. M.: Structure and Function of the Universal Stress Protein TeaD and its Role in Regulating the Ectoine Transporter TeaABC of Halomonas elongata DSM 2581T. Biochemistry 49 (10), pp. 2194 - 2204 (2010)
2009
Journal Article
Krämer, R.; Ziegler, C.: Regulative interactions of the osmosensing C-terminal domain in the trimeric glycine betaine transporter BetP from Corynebacterium glutamicum. Biological Chemistry 390 (8), pp. 685 - 691 (2009)
Journal Article
Appel, M.; Hizlan, D.; Vinothkumar, K. R.; Ziegler, C.; Kühlbrandt, W.: Conformations of NhaA, the Na+/H+ Exchanger from Escherichia coli, in the pH-Activated and Ion-Translocating States. Journal of Molecular Biology 388 (3), pp. 659 - 672 (2009)
Journal Article
Ressl, S.; Terwisscha van Scheltinga, A. C.; Vonrhein, C.; Ott, V.; Ziegler, C.: Molecular basis of transport and regulation in the Na+/betaine symporter BetP. Nature 458 (7234), pp. 47 - 52 (2009)
2008
Journal Article
Kuhlmann, S. I.; Terwisscha van Scheltinga, A. C.; Bienert, R.; Kunte, H.-J.; Ziegler, C.: 1.55 Å Structure of the Ectoine Binding Protein TeaA of the Osmoregulated TRAP-Transporter TeaABC from Halomonas elongata. Biochemistry 47 (36), pp. 9475 - 9485 (2008)
2007
Journal Article
Tsai, C.-J.; Ejsing, C. S.; Shevchenko, A.; Ziegler, C.: The role of lipids and salts in two-dimensional crystallization of the glycine–betaine transporter BetP from Corynebacterium glutamicum. Journal of Structural Biology 160 (3), pp. 275 - 286 (2007)
2006
Journal Article
Kedrov, A.; Ziegler, C.; Muller, D. J.: Differentiating Ligand and Inhibitor Interactions of a Single Antiporter. Journal of Molecular Biology 362 (5), pp. 925 - 932 (2006)
Journal Article
Kedrov, A.; Janovjak, H.; Ziegler, C.; Kuhlbrandt, W.; Muller, D. J.: Observing Folding Pathways and Kinetics of a Single Sodium-proton Antiporter from Escherichia coli. Journal of Molecular Biology 355, pp. 2 - 8 (2006)
2005
Journal Article
Kedrov, A.; Krieg, M.; Ziegler, C.; Kühlbrandt, W.; Muller, D.: Locating ligand binding and activation of a single antiporter. EMBO Reports 6 (7), pp. 668 - 674 (2005)
Journal Article
Tsai, C.-J.; Ziegler, C.: Structure Determination of Secondary Transport Proteins by Electron Crystallography: Two-Dimensional Crystallization of the Betaine Uptake System BetP. Journal of Molecular Microbiology and Biotechnology 10 (2-4), pp. 197 - 207 (2005)
2004
Journal Article
Kedrov, A.; Ziegler, C.; Janovjak, H.; Kühlbrandt, W.; Müller, D. J.: Controlled Unfolding and Refolding of a Single Sodium-proton Antiporter using Atomic Force Microscopy. Journal of Molecular Biology (London) 340 (5), pp. 1143 - 1152 (2004)
Journal Article
Ziegler, C.; Morbach, S.; Schiller, D.; Krämer, R.; Tziatzios, R.; Schubert, D.; Kühlbrandt, W.: Projection Structure and Oligomeric State of the Osmoregulated Sodium/Glycine Betaine Symporter BetP of Corynebacterium glutamicum. Journal of Molecular Biology 337 (5), pp. 1137 - 1147 (2004)

Conference Paper (1)

2011
Conference Paper
Khafizov, K.; Perez, C.; Tsai, C.-J.; Ziegler, C.; Forrest, L. R.: Computational and Experimental Studies of Substrate Binding, Conformational Change and Importance of the Trimeric State in the Glycine Betaine Transporter BetP. Biophysical Journal (Annual Meeting Abstracts) 100 (3, Supplement 1), p. 132a - 132a (2011)
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